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- W2171844672 endingPage "S346" @default.
- W2171844672 startingPage "S339" @default.
- W2171844672 abstract "Orphan G protein-coupled receptors (GPCRs) are receptors lacking endogenous ligands. Found by molecular biological analyses, they became the roots of reverse pharmacology, in which receptors are attempted to be matched to potential transmitters. Later, when high-throughput screening technology was applied to reverse pharmacology, dozens of orphan GPCRs became deorphanized. Furthermore, novel neuropeptides were discovered. This review retraces the history of the orphan GPCRs and of the discoveries of their endogenous ligands, it also discusses the difficulties that the search for new ligands is presently encountering." @default.
- W2171844672 created "2016-06-24" @default.
- W2171844672 creator A5035002612 @default.
- W2171844672 creator A5054192358 @default.
- W2171844672 creator A5078825627 @default.
- W2171844672 date "2008-03-01" @default.
- W2171844672 modified "2023-10-01" @default.
- W2171844672 title "Orphan GPCR research" @default.
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- W2171844672 doi "https://doi.org/10.1038/sj.bjp.0707606" @default.
- W2171844672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268047" @default.
- W2171844672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18071299" @default.