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• W2171846995 startingPage "10477" @default.
• W2171846995 abstract "Here we describe the properties of CP-154,526, a potent and selective nonpeptide antagonist of corticotropin (ACTH) releasing factor (CRF) receptors. CP-154,526 binds with high affinity to CRF receptors (Ki < 10 nM) and blocks CRF-stimulated adenylate cyclase activity in membranes prepared from rat cortex and pituitary. Systemically administered CP-154,526 antagonizes the stimulatory effects of exogenous CRF on plasma ACTH, locus coeruleus neuronal firing and startle response amplitude. Potential anxiolytic activity of CP-154,526 was revealed in a fearpotentiated startle paradigm. These data are presented in the context of clinical findings, which suggest that CRF is hypersecreted in certain pathological states. We propose that a CRF antagonist such as CP-154,526 could affirm the role of CRF in certain psychiatric diseases and may be of significant value in the treatment of these disorders." @default.
• W2171846995 created "2016-06-24" @default.
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• W2171846995 date "1996-09-17" @default.
• W2171846995 modified "2023-10-03" @default.
• W2171846995 title "CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors." @default.
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• W2171846995 doi "https://doi.org/10.1073/pnas.93.19.10477" @default.
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