FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171848174> ?p ?o ?g. }

• W2171848174 endingPage "7095" @default.
• W2171848174 startingPage "7093" @default.
• W2171848174 abstract "The unique Gag polyprotein of the replication-defective virus responsible for murine AIDS (MAIDS) induces B-cell activation, proliferation, and differentiation, including immunoglobulin class switch-recombination to immunoglobulin E (IgE). Secretion of IgE normally requires the serial induction of interleukin 4 (IL-4), engagement of the IL-4 receptor, activation of signal transducer and activator of transcription (STAT) 6, and induction of Iepsilon germline transcripts as a prelude to switching. Remarkably, expression of IgE is equivalent in normal and IL-4-deficient mice with MAIDS (Morawetz et al., J. Exp. Med. 184:1651-1661, 1996). To understand this anomaly, we studied mice with a null mutation of STAT6. Lymphoproliferation and immunodeficiency, the hallmarks of MAIDS, developed with comparable kinetics and degree in normal and mutant mice. In addition, serum IgE levels were indistinguishable in mice of either genotype. We conclude that B cells from mice with MAIDS activate unique IL-4- and STAT6-independent signaling pathways for B-cell activation and differentiation." @default.
• W2171848174 created "2016-06-24" @default.
• W2171848174 creator A5026308918 @default.
• W2171848174 creator A5026913789 @default.
• W2171848174 creator A5044899355 @default.
• W2171848174 creator A5055931220 @default.
• W2171848174 creator A5089700167 @default.
• W2171848174 date "1999-08-01" @default.
• W2171848174 modified "2023-10-14" @default.
• W2171848174 title "STAT6-Deficient Mice Exhibit Normal Induction of Murine AIDS and Expression of Immunoglobulin E following Infection with LP-BM5 Murine Leukemia Viruses" @default.
• W2171848174 cites W1494753294 @default.
• W2171848174 cites W1498992791 @default.
• W2171848174 cites W1667730705 @default.
• W2171848174 cites W1671367056 @default.
• W2171848174 cites W1897890183 @default.
• W2171848174 cites W1952037122 @default.
• W2171848174 cites W1952244035 @default.
• W2171848174 cites W2002186586 @default.
• W2171848174 cites W2029860358 @default.
• W2171848174 cites W2039666331 @default.
• W2171848174 cites W2041636434 @default.
• W2171848174 cites W2044673785 @default.
• W2171848174 cites W2047526826 @default.
• W2171848174 cites W2052172628 @default.
• W2171848174 cites W2059289017 @default.
• W2171848174 cites W2118078649 @default.
• W2171848174 cites W2127499252 @default.
• W2171848174 cites W2134818464 @default.
• W2171848174 cites W2151871635 @default.
• W2171848174 cites W2171240745 @default.
• W2171848174 cites W4239790587 @default.
• W2171848174 doi "https://doi.org/10.1128/jvi.73.8.7093-7095.1999" @default.
• W2171848174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/112803" @default.
• W2171848174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10400816" @default.
• W2171848174 hasPublicationYear "1999" @default.
• W2171848174 type Work @default.
• W2171848174 sameAs 2171848174 @default.
• W2171848174 citedByCount "9" @default.
• W2171848174 countsByYear W21718481742016 @default.
• W2171848174 countsByYear W21718481742020 @default.
• W2171848174 crossrefType "journal-article" @default.
• W2171848174 hasAuthorship W2171848174A5026308918 @default.
• W2171848174 hasAuthorship W2171848174A5026913789 @default.
• W2171848174 hasAuthorship W2171848174A5044899355 @default.
• W2171848174 hasAuthorship W2171848174A5055931220 @default.
• W2171848174 hasAuthorship W2171848174A5089700167 @default.
• W2171848174 hasBestOaLocation W21718481741 @default.
• W2171848174 hasConcept C137756551 @default.
• W2171848174 hasConcept C141105273 @default.
• W2171848174 hasConcept C145430368 @default.
• W2171848174 hasConcept C153911025 @default.
• W2171848174 hasConcept C159047783 @default.
• W2171848174 hasConcept C159654299 @default.
• W2171848174 hasConcept C171958077 @default.
• W2171848174 hasConcept C191732599 @default.
• W2171848174 hasConcept C203014093 @default.
• W2171848174 hasConcept C2778453870 @default.
• W2171848174 hasConcept C2778923194 @default.
• W2171848174 hasConcept C34814297 @default.
• W2171848174 hasConcept C62478195 @default.
• W2171848174 hasConcept C86803240 @default.
• W2171848174 hasConcept C8891405 @default.
• W2171848174 hasConcept C95444343 @default.
• W2171848174 hasConceptScore W2171848174C137756551 @default.
• W2171848174 hasConceptScore W2171848174C141105273 @default.
• W2171848174 hasConceptScore W2171848174C145430368 @default.
• W2171848174 hasConceptScore W2171848174C153911025 @default.
• W2171848174 hasConceptScore W2171848174C159047783 @default.
• W2171848174 hasConceptScore W2171848174C159654299 @default.
• W2171848174 hasConceptScore W2171848174C171958077 @default.
• W2171848174 hasConceptScore W2171848174C191732599 @default.
• W2171848174 hasConceptScore W2171848174C203014093 @default.
• W2171848174 hasConceptScore W2171848174C2778453870 @default.
• W2171848174 hasConceptScore W2171848174C2778923194 @default.
• W2171848174 hasConceptScore W2171848174C34814297 @default.
• W2171848174 hasConceptScore W2171848174C62478195 @default.
• W2171848174 hasConceptScore W2171848174C86803240 @default.
• W2171848174 hasConceptScore W2171848174C8891405 @default.
• W2171848174 hasConceptScore W2171848174C95444343 @default.
• W2171848174 hasIssue "8" @default.
• W2171848174 hasLocation W21718481741 @default.
• W2171848174 hasLocation W21718481742 @default.
• W2171848174 hasLocation W21718481743 @default.
• W2171848174 hasLocation W21718481744 @default.
• W2171848174 hasOpenAccess W2171848174 @default.
• W2171848174 hasPrimaryLocation W21718481741 @default.
• W2171848174 hasRelatedWork W1539910874 @default.
• W2171848174 hasRelatedWork W1654343738 @default.
• W2171848174 hasRelatedWork W1733081509 @default.
• W2171848174 hasRelatedWork W2016307320 @default.
• W2171848174 hasRelatedWork W2024252348 @default.
• W2171848174 hasRelatedWork W2041896789 @default.
• W2171848174 hasRelatedWork W2084701318 @default.
• W2171848174 hasRelatedWork W2411622805 @default.
• W2171848174 hasRelatedWork W4206021265 @default.
• W2171848174 hasRelatedWork W4310259000 @default.
• W2171848174 hasVolume "73" @default.
• W2171848174 isParatext "false" @default.

• next