FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171848502> ?p ?o ?g. }

• W2171848502 endingPage "7721" @default.
• W2171848502 startingPage "7710" @default.
• W2171848502 abstract "ABSTRACT dUTPase is a ubiquitous and essential enzyme responsible for regulating cellular levels of dUTP. The dut gene exists as single, tandemly duplicated, and tandemly triplicated copies. Crystallized single-copy dUTPases have been shown to assemble as homotrimers. dUTPase is encoded as an auxiliary gene in a number of virus genomes. The origin of viral dut genes has remained unresolved since their initial discovery. A comprehensive analysis of dUTPase amino acid sequence relationships was performed to explore the evolutionary dynamics of dut in viruses and their hosts. Our data set, comprised of 24 host and 51 viral sequences, includes representative sequences from available eukaryotes, archaea, eubacteria cells, and viruses, including herpesviruses. These amino acid sequences were aligned by using a hidden Markov model approach developed to align divergent data. Known secondary structures from single-copy crystals were mapped onto the aligned duplicate and triplicate sequences. We show how duplicated dUTPases might fold into a monomer, and we hypothesize that triplicated dUTPases also assemble as monomers. Phylogenetic analysis revealed at least five viral dUTPase sequence lineages in well-supported monophyletic clusters with eukaryotic, eubacterial, and archaeal hosts. We have identified all five as strong examples of horizontal transfer as well as additional potential transfer of dut genes among eubacteria, between eubacteria and viruses, and between retroviruses. The evidence for horizontal transfers is particularly interesting since eukaryotic dut genes have introns, while DNA virus dut genes do not. This implies that an intermediary retroid agent facilitated the horizontal transfer process between host mRNA and DNA viruses." @default.
• W2171848502 created "2016-06-24" @default.
• W2171848502 creator A5039587569 @default.
• W2171848502 creator A5070825086 @default.
• W2171848502 date "1999-09-01" @default.
• W2171848502 modified "2023-09-23" @default.
• W2171848502 title "Evolution and Horizontal Transfer of dUTPase-Encoding Genes in Viruses and Their Hosts" @default.
• W2171848502 cites W1534476045 @default.
• W2171848502 cites W1755609857 @default.
• W2171848502 cites W1764830159 @default.
• W2171848502 cites W1812947354 @default.
• W2171848502 cites W1826522072 @default.
• W2171848502 cites W1837184407 @default.
• W2171848502 cites W1840693540 @default.
• W2171848502 cites W1964643332 @default.
• W2171848502 cites W1968764868 @default.
• W2171848502 cites W1969153299 @default.
• W2171848502 cites W1972396096 @default.
• W2171848502 cites W1980464074 @default.
• W2171848502 cites W1980595371 @default.
• W2171848502 cites W1980946247 @default.
• W2171848502 cites W1996764548 @default.
• W2171848502 cites W2004660869 @default.
• W2171848502 cites W2006249801 @default.
• W2171848502 cites W2008143397 @default.
• W2171848502 cites W2009966494 @default.
• W2171848502 cites W2013126918 @default.
• W2171848502 cites W2024147138 @default.
• W2171848502 cites W2024977466 @default.
• W2171848502 cites W2039500097 @default.
• W2171848502 cites W2041076979 @default.
• W2171848502 cites W2042467869 @default.
• W2171848502 cites W2043759444 @default.
• W2171848502 cites W2044557793 @default.
• W2171848502 cites W2045240688 @default.
• W2171848502 cites W2055043387 @default.
• W2171848502 cites W2056650797 @default.
• W2171848502 cites W2057308017 @default.
• W2171848502 cites W2058638283 @default.
• W2171848502 cites W2063466305 @default.
• W2171848502 cites W2067688949 @default.
• W2171848502 cites W2070981089 @default.
• W2171848502 cites W2073081720 @default.
• W2171848502 cites W2073353609 @default.
• W2171848502 cites W2074231493 @default.
• W2171848502 cites W2074371001 @default.
• W2171848502 cites W2075189542 @default.
• W2171848502 cites W2076360577 @default.
• W2171848502 cites W2077253846 @default.
• W2171848502 cites W2078307653 @default.
• W2171848502 cites W2080153858 @default.
• W2171848502 cites W2084703535 @default.
• W2171848502 cites W2093144235 @default.
• W2171848502 cites W2097013351 @default.
• W2171848502 cites W2097555181 @default.
• W2171848502 cites W2100641815 @default.
• W2171848502 cites W2102122585 @default.
• W2171848502 cites W2102209416 @default.
• W2171848502 cites W2109456246 @default.
• W2171848502 cites W2110132014 @default.
• W2171848502 cites W2111742680 @default.
• W2171848502 cites W2115780677 @default.
• W2171848502 cites W2119053465 @default.
• W2171848502 cites W2123312321 @default.
• W2171848502 cites W2126630901 @default.
• W2171848502 cites W2132515776 @default.
• W2171848502 cites W2134095417 @default.
• W2171848502 cites W2142581556 @default.
• W2171848502 cites W2147948281 @default.
• W2171848502 cites W2149208773 @default.
• W2171848502 cites W2152520284 @default.
• W2171848502 cites W2152615938 @default.
• W2171848502 cites W2167933857 @default.
• W2171848502 cites W2168992245 @default.
• W2171848502 cites W4298262453 @default.
• W2171848502 cites W4320995821 @default.
• W2171848502 cites W2059873421 @default.
• W2171848502 doi "https://doi.org/10.1128/jvi.73.9.7710-7721.1999" @default.
• W2171848502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/104298" @default.
• W2171848502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10438861" @default.
• W2171848502 hasPublicationYear "1999" @default.
• W2171848502 type Work @default.
• W2171848502 sameAs 2171848502 @default.
• W2171848502 citedByCount "98" @default.
• W2171848502 countsByYear W21718485022012 @default.
• W2171848502 countsByYear W21718485022013 @default.
• W2171848502 countsByYear W21718485022014 @default.
• W2171848502 countsByYear W21718485022015 @default.
• W2171848502 countsByYear W21718485022016 @default.
• W2171848502 countsByYear W21718485022017 @default.
• W2171848502 countsByYear W21718485022018 @default.
• W2171848502 countsByYear W21718485022019 @default.
• W2171848502 countsByYear W21718485022020 @default.
• W2171848502 countsByYear W21718485022021 @default.
• W2171848502 countsByYear W21718485022022 @default.
• W2171848502 countsByYear W21718485022023 @default.
• W2171848502 crossrefType "journal-article" @default.
• W2171848502 hasAuthorship W2171848502A5039587569 @default.

• next