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• W2171873266 startingPage "5047" @default.
• W2171873266 abstract "Abstract Intestinal ischemic events, which are followed by reperfusion, induce significant tissue damage and frequently result in multiple organ failure, with &gt;70% mortality. Upon reperfusion, excessive inflammation leads to exacerbated tissue damage. Previous studies indicated that binding of the serum protein, β2-glycoprotein I, to the endothelium initiates a cascade of inflammatory molecules that is required for damage. We hypothesized that peptides derived from the binding domain (domain V) of β2-glycoprotein I would attenuate ischemia/reperfusion-induced damage and inflammation in a therapeutic manner. Using a mouse model of intestinal ischemia/reperfusion, we administered peptides either prior to ischemia or at clinically relevant time points during reperfusion and evaluated intestinal tissue damage and inflammation after 2 h of reperfusion. We demonstrate that multiple peptides attenuate injury and inflammation in a dose-dependent manner and, perhaps more significantly, are efficacious when administered up to 30 min after the onset of reperfusion. In addition, an all D-amino acid retro-inverso peptide was biologically active. Thus, the β2-glycoprotein I-derived peptides attenuate injury and inflammation when administered in a therapeutic manner in intestinal ischemia/reperfusion injury." @default.
• W2171873266 created "2016-06-24" @default.
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• W2171873266 date "2012-11-15" @default.
• W2171873266 modified "2023-10-13" @default.
• W2171873266 title "Small β2-Glycoprotein I Peptides Protect from Intestinal Ischemia Reperfusion Injury" @default.
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• W2171873266 doi "https://doi.org/10.4049/jimmunol.1200290" @default.
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• W2171873266 hasPublicationYear "2012" @default.
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