Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171876247> ?p ?o ?g. }
- W2171876247 endingPage "2805" @default.
- W2171876247 startingPage "2796" @default.
- W2171876247 abstract "Abstract Significant immunological obstacles are to be negotiated before xenotransplantation becomes a clinical reality. An initial rejection of transplanted vascularized xenograft is attributed to Galα1,3Galβ1,4GlcNAc-R (Galα1,3-Gal)–dependent and –independent mechanisms. Hitherto, no receptor molecule has been identified that could account for Galα1,3-Gal–independent rejection. In this study, we identify the tetraspanin CD82 as a receptor molecule for the Galα1,3-Gal–independent mechanism. We demonstrate that, in contrast to human undifferentiated myeloid cell lines, differentiated cell lines are capable of recognizing xenogeneic porcine aortic endothelial cells in a calcium-dependent manner. Transcriptome-wide analysis to identify the differentially expressed transcripts in these cells revealed that the most likely candidate of the Galα1,3-Gal–independent recognition moiety is the tetraspanin CD82. Abs to CD82 inhibited the calcium response and the subsequent activation invoked by xenogeneic encounter. Our data identify CD82 on innate immune cells as a major “xenogenicity sensor” and open new avenues of intervention to making xenotransplantation a clinical reality." @default.
- W2171876247 created "2016-06-24" @default.
- W2171876247 creator A5001969182 @default.
- W2171876247 creator A5002869436 @default.
- W2171876247 creator A5003357950 @default.
- W2171876247 creator A5004492595 @default.
- W2171876247 creator A5035208596 @default.
- W2171876247 creator A5036827313 @default.
- W2171876247 creator A5040854252 @default.
- W2171876247 creator A5047995615 @default.
- W2171876247 creator A5051359695 @default.
- W2171876247 creator A5052375316 @default.
- W2171876247 creator A5053866155 @default.
- W2171876247 creator A5064097084 @default.
- W2171876247 creator A5070508417 @default.
- W2171876247 creator A5085156764 @default.
- W2171876247 creator A5087867261 @default.
- W2171876247 date "2013-09-01" @default.
- W2171876247 modified "2023-10-10" @default.
- W2171876247 title "Identification of the Tetraspanin CD82 as a New Barrier to Xenotransplantation" @default.
- W2171876247 cites W1564625417 @default.
- W2171876247 cites W1620395613 @default.
- W2171876247 cites W1644194792 @default.
- W2171876247 cites W1665767818 @default.
- W2171876247 cites W1821938261 @default.
- W2171876247 cites W1858978092 @default.
- W2171876247 cites W1924064381 @default.
- W2171876247 cites W1965679299 @default.
- W2171876247 cites W1966657745 @default.
- W2171876247 cites W1970987172 @default.
- W2171876247 cites W1972357761 @default.
- W2171876247 cites W1972567646 @default.
- W2171876247 cites W1973335196 @default.
- W2171876247 cites W1975232826 @default.
- W2171876247 cites W1979719264 @default.
- W2171876247 cites W1995978414 @default.
- W2171876247 cites W1996508545 @default.
- W2171876247 cites W2007632920 @default.
- W2171876247 cites W2011189175 @default.
- W2171876247 cites W2016540646 @default.
- W2171876247 cites W2019058511 @default.
- W2171876247 cites W2022194630 @default.
- W2171876247 cites W2031601501 @default.
- W2171876247 cites W2036506426 @default.
- W2171876247 cites W2054132826 @default.
- W2171876247 cites W2055669647 @default.
- W2171876247 cites W2057607651 @default.
- W2171876247 cites W2060572354 @default.
- W2171876247 cites W2060869747 @default.
- W2171876247 cites W2061826103 @default.
- W2171876247 cites W2063871398 @default.
- W2171876247 cites W2079055485 @default.
- W2171876247 cites W2079375104 @default.
- W2171876247 cites W2084714233 @default.
- W2171876247 cites W2085878243 @default.
- W2171876247 cites W2086681390 @default.
- W2171876247 cites W2095000564 @default.
- W2171876247 cites W2098573845 @default.
- W2171876247 cites W2101285353 @default.
- W2171876247 cites W2108009386 @default.
- W2171876247 cites W2113641572 @default.
- W2171876247 cites W2117660132 @default.
- W2171876247 cites W2118847407 @default.
- W2171876247 cites W2119511781 @default.
- W2171876247 cites W2122461521 @default.
- W2171876247 cites W2125376694 @default.
- W2171876247 cites W2125558666 @default.
- W2171876247 cites W2127722696 @default.
- W2171876247 cites W2128223467 @default.
- W2171876247 cites W2129751263 @default.
- W2171876247 cites W2131483535 @default.
- W2171876247 cites W2144657906 @default.
- W2171876247 cites W2145345239 @default.
- W2171876247 cites W2146092834 @default.
- W2171876247 cites W2148591507 @default.
- W2171876247 cites W2157878804 @default.
- W2171876247 cites W2158815200 @default.
- W2171876247 cites W2159800908 @default.
- W2171876247 cites W2162203116 @default.
- W2171876247 cites W2163505131 @default.
- W2171876247 cites W2169220518 @default.
- W2171876247 cites W2337397974 @default.
- W2171876247 cites W2791030205 @default.
- W2171876247 doi "https://doi.org/10.4049/jimmunol.1300601" @default.
- W2171876247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3748337" @default.
- W2171876247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23872050" @default.
- W2171876247 hasPublicationYear "2013" @default.
- W2171876247 type Work @default.
- W2171876247 sameAs 2171876247 @default.
- W2171876247 citedByCount "11" @default.
- W2171876247 countsByYear W21718762472013 @default.
- W2171876247 countsByYear W21718762472015 @default.
- W2171876247 countsByYear W21718762472016 @default.
- W2171876247 countsByYear W21718762472017 @default.
- W2171876247 countsByYear W21718762472020 @default.
- W2171876247 countsByYear W21718762472021 @default.
- W2171876247 countsByYear W21718762472022 @default.
- W2171876247 crossrefType "journal-article" @default.