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• W2171877493 abstract "Interferon gamma (IFNγ) and interleukin 4, 10 and 12 (IL-4, -10, -12) production was measured in whole peripheral blood (WPB) and peripheral blood mononuclear cells (PBMC) of 10 chronic hepatitis C (CHC) patients. The level of IFNγ in supernatants in mitogen-activated WPB was lower than in healthy donors. IL-10 served as a possible downregulative factor for IFNγ, since its spontaneous IL-10 production was enhanced in CHC. Neutralization of IL-10 partly restored IFNγ response in CHC patients. Recombinant IL-12 (rIL-12) also enhanced IFNγ of CHC patients, but IL-12 production was decreased in CHC. Thus, IFNγ production deficiency in CHC patients is secondary to blockage by high levels of IL-10-impaired IL-12 production." @default.
• W2171877493 created "2016-06-24" @default.
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• W2171877493 date "1997-01-01" @default.
• W2171877493 modified "2023-09-26" @default.
• W2171877493 title "Chronic hepatitis C: T-helperl/T-helper2 imbalance could cause virus persistence in peripheral blood" @default.
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• W2171877493 doi "https://doi.org/10.3109/00365519709105232" @default.
• W2171877493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9458493" @default.
• W2171877493 hasPublicationYear "1997" @default.
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