FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171882907> ?p ?o ?g. }

• W2171882907 endingPage "94" @default.
• W2171882907 startingPage "87" @default.
• W2171882907 abstract "The purpose of the present study was to examine the relationship between elevation in intracellular Ca2+ concentration ([Ca2+]i) and development of neuronal damage after cytotoxic hypoxia in vitro. Chick telencephalic neurons were exposed to NaCN 1 mM for up to 2 h. [Ca2+]i was assessed by means of fura-2 based microfluorometry and viability was measured by means of trypan blue exclusion on the same relocated cells for a period of 24 h after initiation of hypoxia. Exposure to sodium cyanide resulted in an up to 10 fold increase in [Ca2+]i and led to subsequent neuronal damage. According to [Ca2+]i and viability neurons in four different stages could be revealed. The percentage of neurons showing elevated [Ca2+]i paralleled exactly the percentage of neuronal damage. The elevation in [Ca2+]i clearly preceded neuronal damage suggesting a time window for pharmacological intervention. The NMDA antagonists dizocilpine, memantine and amantadine were capable of reducing the percentage of neurons showing elevated [Ca2+]i and attenuated neuronal damage. Dizocilpine proved to be the most potent and amantadine to be the weakest antagonist whereas the α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo-(F)-quinoxaline (NBQX) was ineffective. Under our experimental conditions, measurement of [Ca2+]i was able to predict the extent of neuronal damage as well as the neuroprotective potency of drugs." @default.
• W2171882907 created "2016-06-24" @default.
• W2171882907 creator A5028603581 @default.
• W2171882907 creator A5060804724 @default.
• W2171882907 date "1996-09-01" @default.
• W2171882907 modified "2023-10-18" @default.
• W2171882907 title "Determination of intracellular Ca2+ concentration can be a useful tool to predict neuronal damage and neuroprotective properties of drugs" @default.
• W2171882907 cites W116752391 @default.
• W2171882907 cites W1519184577 @default.
• W2171882907 cites W1523671473 @default.
• W2171882907 cites W1590954967 @default.
• W2171882907 cites W1639407471 @default.
• W2171882907 cites W1791689008 @default.
• W2171882907 cites W1890775238 @default.
• W2171882907 cites W1920015810 @default.
• W2171882907 cites W1927766581 @default.
• W2171882907 cites W1967183207 @default.
• W2171882907 cites W1967211953 @default.
• W2171882907 cites W1973408614 @default.
• W2171882907 cites W1979406476 @default.
• W2171882907 cites W1983920417 @default.
• W2171882907 cites W1991178310 @default.
• W2171882907 cites W1992026104 @default.
• W2171882907 cites W2006842487 @default.
• W2171882907 cites W2007449350 @default.
• W2171882907 cites W2009522056 @default.
• W2171882907 cites W2009619183 @default.
• W2171882907 cites W2010044432 @default.
• W2171882907 cites W2016575029 @default.
• W2171882907 cites W2023625072 @default.
• W2171882907 cites W2024773521 @default.
• W2171882907 cites W2024935441 @default.
• W2171882907 cites W2025340934 @default.
• W2171882907 cites W2025497070 @default.
• W2171882907 cites W2026389045 @default.
• W2171882907 cites W2026785105 @default.
• W2171882907 cites W2033731347 @default.
• W2171882907 cites W2035750459 @default.
• W2171882907 cites W2039758676 @default.
• W2171882907 cites W2042550512 @default.
• W2171882907 cites W2042790831 @default.
• W2171882907 cites W2044069594 @default.
• W2171882907 cites W2056223650 @default.
• W2171882907 cites W2066168019 @default.
• W2171882907 cites W2073883806 @default.
• W2171882907 cites W2082249282 @default.
• W2171882907 cites W2093755310 @default.
• W2171882907 cites W2100893066 @default.
• W2171882907 cites W2115217673 @default.
• W2171882907 cites W2118907032 @default.
• W2171882907 cites W2136504105 @default.
• W2171882907 cites W2141260882 @default.
• W2171882907 cites W2162032112 @default.
• W2171882907 cites W2174668858 @default.
• W2171882907 doi "https://doi.org/10.1016/0006-8993(96)00494-5" @default.
• W2171882907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8891272" @default.
• W2171882907 hasPublicationYear "1996" @default.
• W2171882907 type Work @default.
• W2171882907 sameAs 2171882907 @default.
• W2171882907 citedByCount "20" @default.
• W2171882907 countsByYear W21718829072023 @default.
• W2171882907 crossrefType "journal-article" @default.
• W2171882907 hasAuthorship W2171882907A5028603581 @default.
• W2171882907 hasAuthorship W2171882907A5060804724 @default.
• W2171882907 hasConcept C160268369 @default.
• W2171882907 hasConcept C170493617 @default.
• W2171882907 hasConcept C181080969 @default.
• W2171882907 hasConcept C185592680 @default.
• W2171882907 hasConcept C25498285 @default.
• W2171882907 hasConcept C2777836312 @default.
• W2171882907 hasConcept C2779484449 @default.
• W2171882907 hasConcept C2780076171 @default.
• W2171882907 hasConcept C55493867 @default.
• W2171882907 hasConcept C61174792 @default.
• W2171882907 hasConcept C67018056 @default.
• W2171882907 hasConcept C79879829 @default.
• W2171882907 hasConcept C86803240 @default.
• W2171882907 hasConcept C98274493 @default.
• W2171882907 hasConceptScore W2171882907C160268369 @default.
• W2171882907 hasConceptScore W2171882907C170493617 @default.
• W2171882907 hasConceptScore W2171882907C181080969 @default.
• W2171882907 hasConceptScore W2171882907C185592680 @default.
• W2171882907 hasConceptScore W2171882907C25498285 @default.
• W2171882907 hasConceptScore W2171882907C2777836312 @default.
• W2171882907 hasConceptScore W2171882907C2779484449 @default.
• W2171882907 hasConceptScore W2171882907C2780076171 @default.
• W2171882907 hasConceptScore W2171882907C55493867 @default.
• W2171882907 hasConceptScore W2171882907C61174792 @default.
• W2171882907 hasConceptScore W2171882907C67018056 @default.
• W2171882907 hasConceptScore W2171882907C79879829 @default.
• W2171882907 hasConceptScore W2171882907C86803240 @default.
• W2171882907 hasConceptScore W2171882907C98274493 @default.
• W2171882907 hasIssue "1-2" @default.
• W2171882907 hasLocation W21718829071 @default.
• W2171882907 hasLocation W21718829072 @default.
• W2171882907 hasOpenAccess W2171882907 @default.
• W2171882907 hasPrimaryLocation W21718829071 @default.
• W2171882907 hasRelatedWork W1990079576 @default.

• next