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• W2171896521 endingPage "6104" @default.
• W2171896521 startingPage "6094" @default.
• W2171896521 abstract "ABSTRACT The Escherichia coli guaB promoter (P guaB ) is responsible for directing transcription of the guaB and guaA genes, which specify the biosynthesis of the nucleotide GMP. P guaB is subject to growth rate-dependent control (GRDC) and possesses an UP element that is required for this regulation. In addition, P guaB contains a discriminator, three binding sites for the nucleoid-associated protein FIS, and putative binding sites for the regulatory proteins DnaA, PurR, and cyclic AMP receptor protein (CRP). Here we show that the CRP-cyclic AMP (cAMP) complex binds to a site located over 100 bp upstream of the guaB transcription start site, where it serves to downregulate P guaB . The CRP-mediated repression of P guaB activity increases in media that support lower growth rates. Inactivation of the crp or cyaA gene or ablation/translocation of the CRP site relieves repression by CRP and results in a loss of GRDC of P guaB . Thus, GRDC of P guaB involves a progressive increase in CRP-mediated repression of the promoter as the growth rate decreases. Our results also suggest that the CRP-cAMP complex does not direct GRDC at P guaB and that at least one other regulatory factor is required for conferring GRDC on this promoter. However, PurR and DnaA are not required for this regulatory mechanism." @default.
• W2171896521 created "2016-06-24" @default.
• W2171896521 creator A5042124702 @default.
• W2171896521 creator A5051303521 @default.
• W2171896521 creator A5058002828 @default.
• W2171896521 date "2009-10-01" @default.
• W2171896521 modified "2023-10-11" @default.
• W2171896521 title "Downregulation of the <i>Escherichia coli guaB</i> Promoter by Upstream-Bound Cyclic AMP Receptor Protein" @default.
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• W2171896521 doi "https://doi.org/10.1128/jb.00672-09" @default.
• W2171896521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747903" @default.
• W2171896521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19633076" @default.
• W2171896521 hasPublicationYear "2009" @default.
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