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• W2171898601 endingPage "2768" @default.
• W2171898601 startingPage "2751" @default.
• W2171898601 abstract "Cyanobacterial blooms are a major and growing problem for freshwater ecosystems worldwide that increasingly concerns public health, with an average of 60% of blooms known to be toxic. The most studied cyanobacterial toxins belong to a family of cyclic heptapeptide hepatotoxins, called microcystins. The microcystins are stable hydrophilic cyclic heptapeptides with a potential to cause cell damage following cellular uptake via organic anion-transporting proteins (OATP). Their intracellular biologic effects presumably involve inhibition of catalytic subunits of protein phosphatases (PP1 and PP2A) and glutathione depletion. The microcystins produced by cyanobacteria pose a serious problem to human health, if they contaminate drinking water or food. These toxins are collectively responsible for human fatalities, as well as continued and widespread poisoning of wild and domestic animals. Although intoxications of aquatic organisms by microcystins have been widely documented for freshwater ecosystems, such poisonings in marine environments have only occasionally been reported. Moreover, these poisonings have been attributed to freshwater cyanobacterial species invading seas of lower salinity (e.g., the Baltic) or to the discharge of freshwater microcystins into the ocean. However, recent data suggest that microcystins are also being produced in the oceans by a number of cosmopolitan marine species, so that Hepatotoxic Seafood Poisoning (HSP) is increasingly recognized as a major health risk that follows consumption of contaminated seafood." @default.
• W2171898601 created "2016-06-24" @default.
• W2171898601 creator A5016066537 @default.
• W2171898601 creator A5037444805 @default.
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• W2171898601 creator A5062220819 @default.
• W2171898601 creator A5079966425 @default.
• W2171898601 creator A5083149674 @default.
• W2171898601 date "2013-08-05" @default.
• W2171898601 modified "2023-10-08" @default.
• W2171898601 title "Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean?" @default.
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