Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171899178> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2171899178 endingPage "111" @default.
- W2171899178 startingPage "107" @default.
- W2171899178 abstract "The mechanism by which 12-o-tetradecanoylphorbol-13-acetate (TPA) desensitizes carbachol mobilization of glucose-incorporated calcium (Ca2+) was studied in clonal insulin-releasing cells (RINm5F) using colour indicators and dual wavelength spectrophotometry. The net uptake of Ca2+ stimulated by 20 mM glucose reached saturation after 19 +/- 2 min when it corresponded to 1.21 +/- 0.09 mmol calcium kg-1 protein. Carbachol then induced a release of 0.21 +/- 0.03 mmol calcium kg-1 protein. Half of the remaining Ca2+ was liberated by antimycin A and the rest with the Ca2+ ionophore A-23187. When 0.1 microM TPA was added initially, the cells lost 0.29 +/- 0.08 mmol calcium kg-1 protein within 10 min. The subsequent addition of glucose resulted in a sluggish uptake of only 0.58 +/- 0.09 mmol calcium kg-1 protein reaching equilibrium after 35 +/- 3 min. Carbachol now failed to induce any Ca2+ release. The actions of TPA were essentially unchanged by previous exposure to glucose, removal of Na+ from the medium and even when some of the glucose-incorporated Ca2+ had been liberated with carbachol. The results indicate that TPA desensitization of carbachol-induced mobilization of Ca2+ in the RINm5F cells is due to the disappearance of Ca2+ from the sensitive pool, an effect which may depend on stimulated extrusion of Ca2+ from the cells by the (Ca2+-Mg2+)-ATPase." @default.
- W2171899178 created "2016-06-24" @default.
- W2171899178 creator A5055074357 @default.
- W2171899178 date "1989-02-01" @default.
- W2171899178 modified "2023-09-27" @default.
- W2171899178 title "Phorbol ester desensitization of clonal insulin-releasing cell response to carbachol involves depletion of an intracellular calcium pool" @default.
- W2171899178 cites W1967086988 @default.
- W2171899178 cites W1975602638 @default.
- W2171899178 cites W1977307439 @default.
- W2171899178 cites W2050850950 @default.
- W2171899178 cites W2053528757 @default.
- W2171899178 cites W2064923916 @default.
- W2171899178 cites W2067706502 @default.
- W2171899178 cites W2068823120 @default.
- W2171899178 cites W2068877244 @default.
- W2171899178 cites W2079048446 @default.
- W2171899178 cites W2083962478 @default.
- W2171899178 cites W2089174955 @default.
- W2171899178 cites W2091156380 @default.
- W2171899178 cites W2094954950 @default.
- W2171899178 cites W2135125272 @default.
- W2171899178 cites W2170799117 @default.
- W2171899178 cites W2218403511 @default.
- W2171899178 cites W2225996377 @default.
- W2171899178 doi "https://doi.org/10.1111/j.1748-1716.1989.tb08557.x" @default.
- W2171899178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2646851" @default.
- W2171899178 hasPublicationYear "1989" @default.
- W2171899178 type Work @default.
- W2171899178 sameAs 2171899178 @default.
- W2171899178 citedByCount "9" @default.
- W2171899178 countsByYear W21718991782012 @default.
- W2171899178 crossrefType "journal-article" @default.
- W2171899178 hasAuthorship W2171899178A5055074357 @default.
- W2171899178 hasConcept C126322002 @default.
- W2171899178 hasConcept C134018914 @default.
- W2171899178 hasConcept C170493617 @default.
- W2171899178 hasConcept C178790620 @default.
- W2171899178 hasConcept C185592680 @default.
- W2171899178 hasConcept C24998067 @default.
- W2171899178 hasConcept C2778988552 @default.
- W2171899178 hasConcept C2779014961 @default.
- W2171899178 hasConcept C2779306644 @default.
- W2171899178 hasConcept C2779779143 @default.
- W2171899178 hasConcept C519063684 @default.
- W2171899178 hasConcept C55493867 @default.
- W2171899178 hasConcept C71924100 @default.
- W2171899178 hasConcept C86803240 @default.
- W2171899178 hasConceptScore W2171899178C126322002 @default.
- W2171899178 hasConceptScore W2171899178C134018914 @default.
- W2171899178 hasConceptScore W2171899178C170493617 @default.
- W2171899178 hasConceptScore W2171899178C178790620 @default.
- W2171899178 hasConceptScore W2171899178C185592680 @default.
- W2171899178 hasConceptScore W2171899178C24998067 @default.
- W2171899178 hasConceptScore W2171899178C2778988552 @default.
- W2171899178 hasConceptScore W2171899178C2779014961 @default.
- W2171899178 hasConceptScore W2171899178C2779306644 @default.
- W2171899178 hasConceptScore W2171899178C2779779143 @default.
- W2171899178 hasConceptScore W2171899178C519063684 @default.
- W2171899178 hasConceptScore W2171899178C55493867 @default.
- W2171899178 hasConceptScore W2171899178C71924100 @default.
- W2171899178 hasConceptScore W2171899178C86803240 @default.
- W2171899178 hasIssue "2" @default.
- W2171899178 hasLocation W21718991781 @default.
- W2171899178 hasLocation W21718991782 @default.
- W2171899178 hasOpenAccess W2171899178 @default.
- W2171899178 hasPrimaryLocation W21718991781 @default.
- W2171899178 hasRelatedWork W160797072 @default.
- W2171899178 hasRelatedWork W1901275661 @default.
- W2171899178 hasRelatedWork W1997540440 @default.
- W2171899178 hasRelatedWork W2003842308 @default.
- W2171899178 hasRelatedWork W2032033142 @default.
- W2171899178 hasRelatedWork W2048823012 @default.
- W2171899178 hasRelatedWork W2143145536 @default.
- W2171899178 hasRelatedWork W2171899178 @default.
- W2171899178 hasRelatedWork W2409488646 @default.
- W2171899178 hasRelatedWork W2411696477 @default.
- W2171899178 hasVolume "135" @default.
- W2171899178 isParatext "false" @default.
- W2171899178 isRetracted "false" @default.
- W2171899178 magId "2171899178" @default.
- W2171899178 workType "article" @default.