Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171946189> ?p ?o ?g. }
- W2171946189 endingPage "2064" @default.
- W2171946189 startingPage "2056" @default.
- W2171946189 abstract "Background— We previously used adenosine A 2A receptor (A2AR) knockout (KO) mice and bone marrow transplantation to show that the infarct-sparing effect of A2AR activation at reperfusion is primarily due to effects on bone marrow–derived cells. In this study we show that CD4 + but not CD8 + T lymphocytes contribute to myocardial ischemia/reperfusion injury. Method and Results— After a 45-minute occlusion of the left anterior descending coronary artery and reperfusion, T cells accumulate in the infarct zone within 2 minutes. Addition of 10 μg/kg of the A2AR agonist ATL146e 5 minutes before reperfusion produces a significant reduction in T-cell accumulation and a significant reduction in infarct size (percentage of risk area) measured at 24 hours. In Rag1 KO mice lacking mature lymphocytes, infarct size is significantly smaller than in C57BL/6 mice. Infarct size in Rag1 KO mice is increased to the level of B6 mice by adoptive transfer of 50 million CD4 + T lymphocytes derived from C57BL/6 or A2AR KO but not interferon-γ KO mice. ATL146e completely blocked the increase in infarct size in Rag1 KO mice reconstituted with B6 but not A2AR KO CD4 + T cells. The number of neutrophils in the reperfused heart at 24 hours after infarction correlated well with the number of lymphocytes and infarct size. Conclusions— These results strongly suggest that the infarct-sparing effect of A2AR activation is primarily due to inhibition of CD4 + T-cell accumulation and activation in the reperfused heart." @default.
- W2171946189 created "2016-06-24" @default.
- W2171946189 creator A5008325688 @default.
- W2171946189 creator A5025561543 @default.
- W2171946189 creator A5031349718 @default.
- W2171946189 creator A5037626828 @default.
- W2171946189 creator A5038818680 @default.
- W2171946189 creator A5039190016 @default.
- W2171946189 creator A5058862343 @default.
- W2171946189 creator A5062177629 @default.
- W2171946189 date "2006-11-07" @default.
- W2171946189 modified "2023-10-16" @default.
- W2171946189 title "Myocardial Infarct–Sparing Effect of Adenosine A<sub>2A</sub>Receptor Activation Is due to Its Action on CD4<sup>+</sup>T Lymphocytes" @default.
- W2171946189 cites W1557678369 @default.
- W2171946189 cites W1563909789 @default.
- W2171946189 cites W1964292228 @default.
- W2171946189 cites W1966333025 @default.
- W2171946189 cites W1978633622 @default.
- W2171946189 cites W1988316765 @default.
- W2171946189 cites W1990113288 @default.
- W2171946189 cites W1990312588 @default.
- W2171946189 cites W1997931717 @default.
- W2171946189 cites W2003504980 @default.
- W2171946189 cites W2010097756 @default.
- W2171946189 cites W2031795723 @default.
- W2171946189 cites W2043029488 @default.
- W2171946189 cites W2043483628 @default.
- W2171946189 cites W2043551147 @default.
- W2171946189 cites W2066697125 @default.
- W2171946189 cites W2074186920 @default.
- W2171946189 cites W2090864877 @default.
- W2171946189 cites W2103604148 @default.
- W2171946189 cites W2125075553 @default.
- W2171946189 cites W2163809288 @default.
- W2171946189 cites W2169661250 @default.
- W2171946189 cites W2207688454 @default.
- W2171946189 cites W23360501 @default.
- W2171946189 cites W4254004012 @default.
- W2171946189 cites W4313377103 @default.
- W2171946189 doi "https://doi.org/10.1161/circulationaha.106.649244" @default.
- W2171946189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17060376" @default.
- W2171946189 hasPublicationYear "2006" @default.
- W2171946189 type Work @default.
- W2171946189 sameAs 2171946189 @default.
- W2171946189 citedByCount "228" @default.
- W2171946189 countsByYear W21719461892012 @default.
- W2171946189 countsByYear W21719461892013 @default.
- W2171946189 countsByYear W21719461892014 @default.
- W2171946189 countsByYear W21719461892015 @default.
- W2171946189 countsByYear W21719461892016 @default.
- W2171946189 countsByYear W21719461892017 @default.
- W2171946189 countsByYear W21719461892018 @default.
- W2171946189 countsByYear W21719461892019 @default.
- W2171946189 countsByYear W21719461892020 @default.
- W2171946189 countsByYear W21719461892021 @default.
- W2171946189 countsByYear W21719461892022 @default.
- W2171946189 countsByYear W21719461892023 @default.
- W2171946189 crossrefType "journal-article" @default.
- W2171946189 hasAuthorship W2171946189A5008325688 @default.
- W2171946189 hasAuthorship W2171946189A5025561543 @default.
- W2171946189 hasAuthorship W2171946189A5031349718 @default.
- W2171946189 hasAuthorship W2171946189A5037626828 @default.
- W2171946189 hasAuthorship W2171946189A5038818680 @default.
- W2171946189 hasAuthorship W2171946189A5039190016 @default.
- W2171946189 hasAuthorship W2171946189A5058862343 @default.
- W2171946189 hasAuthorship W2171946189A5062177629 @default.
- W2171946189 hasBestOaLocation W21719461891 @default.
- W2171946189 hasConcept C126322002 @default.
- W2171946189 hasConcept C134018914 @default.
- W2171946189 hasConcept C164705383 @default.
- W2171946189 hasConcept C167672396 @default.
- W2171946189 hasConcept C170493617 @default.
- W2171946189 hasConcept C203014093 @default.
- W2171946189 hasConcept C2776090121 @default.
- W2171946189 hasConcept C2776991684 @default.
- W2171946189 hasConcept C2778491162 @default.
- W2171946189 hasConcept C2778938600 @default.
- W2171946189 hasConcept C2780007613 @default.
- W2171946189 hasConcept C2780114680 @default.
- W2171946189 hasConcept C2911091166 @default.
- W2171946189 hasConcept C500558357 @default.
- W2171946189 hasConcept C541997718 @default.
- W2171946189 hasConcept C67907053 @default.
- W2171946189 hasConcept C71924100 @default.
- W2171946189 hasConcept C8891405 @default.
- W2171946189 hasConcept C90375314 @default.
- W2171946189 hasConceptScore W2171946189C126322002 @default.
- W2171946189 hasConceptScore W2171946189C134018914 @default.
- W2171946189 hasConceptScore W2171946189C164705383 @default.
- W2171946189 hasConceptScore W2171946189C167672396 @default.
- W2171946189 hasConceptScore W2171946189C170493617 @default.
- W2171946189 hasConceptScore W2171946189C203014093 @default.
- W2171946189 hasConceptScore W2171946189C2776090121 @default.
- W2171946189 hasConceptScore W2171946189C2776991684 @default.
- W2171946189 hasConceptScore W2171946189C2778491162 @default.
- W2171946189 hasConceptScore W2171946189C2778938600 @default.
- W2171946189 hasConceptScore W2171946189C2780007613 @default.
- W2171946189 hasConceptScore W2171946189C2780114680 @default.