FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171962945> ?p ?o ?g. }

• W2171962945 endingPage "30" @default.
• W2171962945 startingPage "28v" @default.
• W2171962945 abstract "Arterial hypertension (AH) per se is, together with diabetes mellitus, the most important cause of renal failure and of dialysis in the western world. AH is also a well known consequence of chronic renal disease, and at the same time one of the main factors which causes diabetic and/or non-diabetic chronic renal failure progression. AH is mostly registered in patients with focal segmental glomerulosclerosis and with membranoproliferative glomerulonephritis. The pathophysiology and the mechanism of AH within primary glomerular diseases are complex, including activation of the sympathetic nervous system, the renin–angiotensin system (RAS), sodium retention, volume expansion and decreased synthesis of vasodilatatory substances. As autoregulation of glomerular pressure in chronic glomerular disease is disturbed, the increment in systemic blood pressure leads to the rise in glomerular pressure. Glomerular hypertension results in glomerular capillary wall stretch, endothelial damage and a rise in protein glomerular filtration. These processes, in turn, cause changes of mesangial and proximal tubular cells, ultimately resulting in the replacement of functional by non-functional connective tissue and the development of fibrosis. One of the most important factors in the progression of chronic renal failure is activation of the RAS. Its effect is not only elevated blood pressure, but also the promotion of cell proliferation, inflammation and matrix accumulation. Many studies, first in experimental animals and later in humans, have shown that the lowering of blood pressure (and proteinuria) is associated with a slower progression of kidney disease. It seems that angiotensin-converting enzyme inhibitors (ACEIs) are more renoprotective than other antihypertensives (the protection beyond the antihypertensive effect), although some studies have also confirmed a comparatively beneficial effect of non-dihydropiridine calcium channel blockers (CCBs) and angiotensin II receptor blockers (ARBs). Moreover, it seems that a combination of antihypertensives (e.g. ACEI + CCB, ACEI + ARB) has a more effective action than either of the drugs alone. However, the effects depend first on the degree of blood pressure reduction. According to comprehensive studies, the achievement of adequate blood pressure (not higher than 130/85 mmHg) is the most important factor. An even lower blood pressure (125/75 mmHg) has been suggested as the limit value in patients with proteinuria of >1 g/24 h and in Blacks." @default.
• W2171962945 created "2016-06-24" @default.
• W2171962945 creator A5006725553 @default.
• W2171962945 creator A5013260211 @default.
• W2171962945 date "2003-07-01" @default.
• W2171962945 modified "2023-10-17" @default.
• W2171962945 title "The role of arterial hypertension in the progression of non-diabetic glomerular diseases" @default.
• W2171962945 cites W1966122526 @default.
• W2171962945 cites W1970063817 @default.
• W2171962945 cites W2069565710 @default.
• W2171962945 cites W2101387755 @default.
• W2171962945 cites W2119975617 @default.
• W2171962945 cites W2137408480 @default.
• W2171962945 cites W22189248 @default.
• W2171962945 cites W2417494548 @default.
• W2171962945 cites W2410415344 @default.
• W2171962945 doi "https://doi.org/10.1093/ndt/gfg1040" @default.
• W2171962945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12817064" @default.
• W2171962945 hasPublicationYear "2003" @default.
• W2171962945 type Work @default.
• W2171962945 sameAs 2171962945 @default.
• W2171962945 citedByCount "35" @default.
• W2171962945 countsByYear W21719629452012 @default.
• W2171962945 countsByYear W21719629452013 @default.
• W2171962945 countsByYear W21719629452014 @default.
• W2171962945 countsByYear W21719629452015 @default.
• W2171962945 countsByYear W21719629452016 @default.
• W2171962945 countsByYear W21719629452017 @default.
• W2171962945 countsByYear W21719629452019 @default.
• W2171962945 countsByYear W21719629452020 @default.
• W2171962945 countsByYear W21719629452021 @default.
• W2171962945 crossrefType "journal-article" @default.
• W2171962945 hasAuthorship W2171962945A5006725553 @default.
• W2171962945 hasAuthorship W2171962945A5013260211 @default.
• W2171962945 hasBestOaLocation W21719629451 @default.
• W2171962945 hasConcept C126322002 @default.
• W2171962945 hasConcept C134018914 @default.
• W2171962945 hasConcept C159641895 @default.
• W2171962945 hasConcept C2776179406 @default.
• W2171962945 hasConcept C2777390665 @default.
• W2171962945 hasConcept C2778653478 @default.
• W2171962945 hasConcept C2779561371 @default.
• W2171962945 hasConcept C2779922275 @default.
• W2171962945 hasConcept C2780091579 @default.
• W2171962945 hasConcept C555293320 @default.
• W2171962945 hasConcept C71924100 @default.
• W2171962945 hasConcept C84393581 @default.
• W2171962945 hasConceptScore W2171962945C126322002 @default.
• W2171962945 hasConceptScore W2171962945C134018914 @default.
• W2171962945 hasConceptScore W2171962945C159641895 @default.
• W2171962945 hasConceptScore W2171962945C2776179406 @default.
• W2171962945 hasConceptScore W2171962945C2777390665 @default.
• W2171962945 hasConceptScore W2171962945C2778653478 @default.
• W2171962945 hasConceptScore W2171962945C2779561371 @default.
• W2171962945 hasConceptScore W2171962945C2779922275 @default.
• W2171962945 hasConceptScore W2171962945C2780091579 @default.
• W2171962945 hasConceptScore W2171962945C555293320 @default.
• W2171962945 hasConceptScore W2171962945C71924100 @default.
• W2171962945 hasConceptScore W2171962945C84393581 @default.
• W2171962945 hasIssue "90005" @default.
• W2171962945 hasLocation W21719629451 @default.
• W2171962945 hasLocation W21719629452 @default.
• W2171962945 hasOpenAccess W2171962945 @default.
• W2171962945 hasPrimaryLocation W21719629451 @default.
• W2171962945 hasRelatedWork W1495455681 @default.
• W2171962945 hasRelatedWork W1969200756 @default.
• W2171962945 hasRelatedWork W2016921050 @default.
• W2171962945 hasRelatedWork W2032111989 @default.
• W2171962945 hasRelatedWork W2042033030 @default.
• W2171962945 hasRelatedWork W2104195310 @default.
• W2171962945 hasRelatedWork W2127085070 @default.
• W2171962945 hasRelatedWork W3135416317 @default.
• W2171962945 hasRelatedWork W4234818317 @default.
• W2171962945 hasRelatedWork W4244020236 @default.
• W2171962945 hasVolume "18" @default.
• W2171962945 isParatext "false" @default.
• W2171962945 isRetracted "false" @default.
• W2171962945 magId "2171962945" @default.
• W2171962945 workType "article" @default.