Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171982502> ?p ?o ?g. }
- W2171982502 endingPage "806" @default.
- W2171982502 startingPage "799" @default.
- W2171982502 abstract "The mammalian intestine harbors a complex microbial community that provides numerous benefits to its host. However, the microbiota can also include potentially virulent species, termed pathobiont, which can cause disease when intestinal homeostasis is disrupted. The molecular mechanisms by which pathobionts cause disease remain poorly understood. Here we describe a sepsis-like disease that occurs upon gut injury in antibiotic-treated mice. Sepsis was associated with the systemic spread of a specific multidrug-resistant Escherichia coli pathobiont that expanded markedly in the microbiota of antibiotic-treated mice. Rapid sepsis-like death required a component of the innate immune system, the Naip5-Nlrc4 inflammasome. In accordance with Koch's postulates, we found the E. coli pathobiont was sufficient to activate Naip5-Nlrc4 and cause disease when injected intravenously into unmanipulated mice. These findings reveal how sepsis-like disease can result from recognition of pathobionts by the innate immune system." @default.
- W2171982502 created "2016-06-24" @default.
- W2171982502 creator A5055693248 @default.
- W2171982502 creator A5061473047 @default.
- W2171982502 creator A5073610008 @default.
- W2171982502 date "2012-04-22" @default.
- W2171982502 modified "2023-10-10" @default.
- W2171982502 title "Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota" @default.
- W2171982502 cites W1855226200 @default.
- W2171982502 cites W1904553924 @default.
- W2171982502 cites W1953286661 @default.
- W2171982502 cites W1967071507 @default.
- W2171982502 cites W1972896014 @default.
- W2171982502 cites W1975032025 @default.
- W2171982502 cites W1975477890 @default.
- W2171982502 cites W1979573684 @default.
- W2171982502 cites W1980288207 @default.
- W2171982502 cites W1985960016 @default.
- W2171982502 cites W1988197452 @default.
- W2171982502 cites W2003525072 @default.
- W2171982502 cites W2004798786 @default.
- W2171982502 cites W2006377695 @default.
- W2171982502 cites W2008261126 @default.
- W2171982502 cites W2018216113 @default.
- W2171982502 cites W2018983895 @default.
- W2171982502 cites W2030023942 @default.
- W2171982502 cites W2034082915 @default.
- W2171982502 cites W2041136224 @default.
- W2171982502 cites W2047312692 @default.
- W2171982502 cites W2049448291 @default.
- W2171982502 cites W2052874989 @default.
- W2171982502 cites W2057979643 @default.
- W2171982502 cites W2058590329 @default.
- W2171982502 cites W2060267424 @default.
- W2171982502 cites W2062689281 @default.
- W2171982502 cites W2063688039 @default.
- W2171982502 cites W2066327704 @default.
- W2171982502 cites W2083089709 @default.
- W2171982502 cites W2089714303 @default.
- W2171982502 cites W2092888370 @default.
- W2171982502 cites W2096625211 @default.
- W2171982502 cites W2097072854 @default.
- W2171982502 cites W2102446851 @default.
- W2171982502 cites W2102459023 @default.
- W2171982502 cites W2103784576 @default.
- W2171982502 cites W2106822334 @default.
- W2171982502 cites W2113049807 @default.
- W2171982502 cites W2114337065 @default.
- W2171982502 cites W2117054079 @default.
- W2171982502 cites W2127634163 @default.
- W2171982502 cites W2132206417 @default.
- W2171982502 cites W2133308090 @default.
- W2171982502 cites W2135343502 @default.
- W2171982502 cites W2136429020 @default.
- W2171982502 cites W2138840402 @default.
- W2171982502 cites W2139485450 @default.
- W2171982502 cites W2153685214 @default.
- W2171982502 cites W2154070326 @default.
- W2171982502 cites W2155395286 @default.
- W2171982502 cites W2155538302 @default.
- W2171982502 cites W2161886621 @default.
- W2171982502 cites W2167062509 @default.
- W2171982502 cites W2167927725 @default.
- W2171982502 cites W2170266705 @default.
- W2171982502 cites W2170899471 @default.
- W2171982502 cites W2171132114 @default.
- W2171982502 cites W2414367703 @default.
- W2171982502 cites W4211217520 @default.
- W2171982502 cites W4213103515 @default.
- W2171982502 doi "https://doi.org/10.1038/nm.2729" @default.
- W2171982502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3472005" @default.
- W2171982502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22522562" @default.
- W2171982502 hasPublicationYear "2012" @default.
- W2171982502 type Work @default.
- W2171982502 sameAs 2171982502 @default.
- W2171982502 citedByCount "174" @default.
- W2171982502 countsByYear W21719825022012 @default.
- W2171982502 countsByYear W21719825022013 @default.
- W2171982502 countsByYear W21719825022014 @default.
- W2171982502 countsByYear W21719825022015 @default.
- W2171982502 countsByYear W21719825022016 @default.
- W2171982502 countsByYear W21719825022017 @default.
- W2171982502 countsByYear W21719825022018 @default.
- W2171982502 countsByYear W21719825022019 @default.
- W2171982502 countsByYear W21719825022020 @default.
- W2171982502 countsByYear W21719825022021 @default.
- W2171982502 countsByYear W21719825022022 @default.
- W2171982502 countsByYear W21719825022023 @default.
- W2171982502 crossrefType "journal-article" @default.
- W2171982502 hasAuthorship W2171982502A5055693248 @default.
- W2171982502 hasAuthorship W2171982502A5061473047 @default.
- W2171982502 hasAuthorship W2171982502A5073610008 @default.
- W2171982502 hasBestOaLocation W21719825022 @default.
- W2171982502 hasConcept C136449434 @default.
- W2171982502 hasConcept C139964883 @default.
- W2171982502 hasConcept C142724271 @default.
- W2171982502 hasConcept C203014093 @default.
- W2171982502 hasConcept C2776914184 @default.