Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172014976> ?p ?o ?g. }
- W2172014976 endingPage "265" @default.
- W2172014976 startingPage "255" @default.
- W2172014976 abstract "Recent reports have shown that n-3 PUFA-enriched phospholipids have various beneficial effects. The proportion of DHA and eicosapentaenoic acid (EPA) in the phospholipids might affect their biological functions. In the present study, marine DHA-enriched phospholipids (DHA-PL) and EPA-enriched phospholipids (EPA-PL) were administered to high fat (HF) diet-induced obese C57BL/6J mice for 8 weeks to compare their effects on obesity-related metabolic disorders. DHA-PL and EPA-PL significantly decreased epididymal and perirenal adipose tissue weights, reduced blood pressures and lowered serum and hepatic triacylglycerol levels in HF diet-induced obese mice. Serum insulin, MCP-1 and IL-6 levels were also efficiently reduced by treatment with DHA-PL and EPA-PL. The anti-obesity and lipid-lowering effects of EPA-PL were superior to DHA-PL, while DHA-PL exhibited better anti-hypertension effects than EPA-PL. The effects of DHA-PL and EPA-PL on glucose intolerance and inflammation were basically equivalent. DHA-PL and EPA-PL up-regulated genes involved in insulin-sensitizing actions in the adipose tissue and suppressed hepatic SREBP-1c mediated lipogenesis. EPA-PL also significantly activated PPARα mediated fatty acid β-oxidation in the liver. These results indicate that DHA-PL and EPA-PL could efficaciously alleviate obesity-related metabolic disorders but the ameliorative degree and regulatory mechanisms are not identical. Practical applications: This investigation would be useful in the selective development of functional foods containing DHA-PL or EPA-PL contributing to the prevention and treatment of chronic metabolic disease in humans. The study also showed the chemical compositions of phospholipids fractions of squid (Sthenoteuthis oualaniensis) egg and sea cucumber (Cucumaria frondosa) that may be useful for further studies." @default.
- W2172014976 created "2016-06-24" @default.
- W2172014976 creator A5002530698 @default.
- W2172014976 creator A5019126433 @default.
- W2172014976 creator A5030689354 @default.
- W2172014976 creator A5031442159 @default.
- W2172014976 creator A5043894450 @default.
- W2172014976 creator A5045392886 @default.
- W2172014976 creator A5052589066 @default.
- W2172014976 date "2014-01-17" @default.
- W2172014976 modified "2023-09-27" @default.
- W2172014976 title "Comparative study of DHA‐enriched phospholipids and EPA‐enriched phospholipids on metabolic disorders in diet‐induced‐obese C57BL/6J mice" @default.
- W2172014976 cites W1513897103 @default.
- W2172014976 cites W1544426283 @default.
- W2172014976 cites W1775749144 @default.
- W2172014976 cites W1845120775 @default.
- W2172014976 cites W1889359478 @default.
- W2172014976 cites W1912410317 @default.
- W2172014976 cites W1960511523 @default.
- W2172014976 cites W1970533492 @default.
- W2172014976 cites W1971569577 @default.
- W2172014976 cites W1982040447 @default.
- W2172014976 cites W1982178416 @default.
- W2172014976 cites W1988490357 @default.
- W2172014976 cites W1993033782 @default.
- W2172014976 cites W2007855541 @default.
- W2172014976 cites W2026756943 @default.
- W2172014976 cites W2028202810 @default.
- W2172014976 cites W2029100600 @default.
- W2172014976 cites W2034715564 @default.
- W2172014976 cites W2038831823 @default.
- W2172014976 cites W2039657903 @default.
- W2172014976 cites W2041614190 @default.
- W2172014976 cites W2057180728 @default.
- W2172014976 cites W2068069556 @default.
- W2172014976 cites W2079409874 @default.
- W2172014976 cites W2081714214 @default.
- W2172014976 cites W2083226856 @default.
- W2172014976 cites W2088940658 @default.
- W2172014976 cites W2092167363 @default.
- W2172014976 cites W2099129407 @default.
- W2172014976 cites W2100433915 @default.
- W2172014976 cites W2112435058 @default.
- W2172014976 cites W2114801213 @default.
- W2172014976 cites W2115414014 @default.
- W2172014976 cites W2128489196 @default.
- W2172014976 cites W2130957039 @default.
- W2172014976 cites W2134625704 @default.
- W2172014976 cites W2137669138 @default.
- W2172014976 cites W2138907486 @default.
- W2172014976 cites W2141407971 @default.
- W2172014976 cites W2142051619 @default.
- W2172014976 cites W2151025367 @default.
- W2172014976 cites W2153686276 @default.
- W2172014976 cites W2154993634 @default.
- W2172014976 cites W2168526937 @default.
- W2172014976 cites W2206310676 @default.
- W2172014976 cites W253857675 @default.
- W2172014976 cites W4205407119 @default.
- W2172014976 cites W4237772238 @default.
- W2172014976 cites W4252021281 @default.
- W2172014976 doi "https://doi.org/10.1002/ejlt.201300407" @default.
- W2172014976 hasPublicationYear "2014" @default.
- W2172014976 type Work @default.
- W2172014976 sameAs 2172014976 @default.
- W2172014976 citedByCount "56" @default.
- W2172014976 countsByYear W21720149762015 @default.
- W2172014976 countsByYear W21720149762016 @default.
- W2172014976 countsByYear W21720149762017 @default.
- W2172014976 countsByYear W21720149762018 @default.
- W2172014976 countsByYear W21720149762019 @default.
- W2172014976 countsByYear W21720149762020 @default.
- W2172014976 countsByYear W21720149762021 @default.
- W2172014976 countsByYear W21720149762022 @default.
- W2172014976 countsByYear W21720149762023 @default.
- W2172014976 crossrefType "journal-article" @default.
- W2172014976 hasAuthorship W2172014976A5002530698 @default.
- W2172014976 hasAuthorship W2172014976A5019126433 @default.
- W2172014976 hasAuthorship W2172014976A5030689354 @default.
- W2172014976 hasAuthorship W2172014976A5031442159 @default.
- W2172014976 hasAuthorship W2172014976A5043894450 @default.
- W2172014976 hasAuthorship W2172014976A5045392886 @default.
- W2172014976 hasAuthorship W2172014976A5052589066 @default.
- W2172014976 hasConcept C126322002 @default.
- W2172014976 hasConcept C134018914 @default.
- W2172014976 hasConcept C141359234 @default.
- W2172014976 hasConcept C171089720 @default.
- W2172014976 hasConcept C185592680 @default.
- W2172014976 hasConcept C19038510 @default.
- W2172014976 hasConcept C2776091944 @default.
- W2172014976 hasConcept C2777171753 @default.
- W2172014976 hasConcept C543025807 @default.
- W2172014976 hasConcept C55493867 @default.
- W2172014976 hasConcept C71924100 @default.
- W2172014976 hasConcept C86803240 @default.
- W2172014976 hasConceptScore W2172014976C126322002 @default.
- W2172014976 hasConceptScore W2172014976C134018914 @default.
- W2172014976 hasConceptScore W2172014976C141359234 @default.