Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172017171> ?p ?o ?g. }
- W2172017171 endingPage "20057" @default.
- W2172017171 startingPage "20043" @default.
- W2172017171 abstract "Follicular T helper (Tfh) cells are recognized by the expression of CXCR5 and the transcriptional regulator Bcl-6. Tfh cells control B cell maturation and antibody production, and if deregulated, may lead to autoimmunity. Here, we study the role of the proto-oncogene survivin in the formation of Tfh cells. We show that blood Tfh cells of patients with the autoimmune condition rheumatoid arthritis, have intracellular expression of survivin. Survivin was co-localized with Bcl-6 in the nuclei of CXCR5+CD4 lymphocytes and was immunoprecipitated with the Bcl-6 responsive element of the target genes. Inhibition of survivin in arthritic mice led to the reduction of CXCR5+ Tfh cells and to low production of autoantibodies. Exposure to survivin activated STAT3 and induced enrichment of PD-1+Bcl-6+ subset within Tfh cells. Collectively, our study demonstrates that survivin belongs to the Tfh cell phenotype and ensures their optimal function by regulating transcriptional activity of Bcl-6." @default.
- W2172017171 created "2016-06-24" @default.
- W2172017171 creator A5012834094 @default.
- W2172017171 creator A5036910737 @default.
- W2172017171 creator A5040483846 @default.
- W2172017171 creator A5059803104 @default.
- W2172017171 creator A5066540554 @default.
- W2172017171 creator A5075679467 @default.
- W2172017171 creator A5082063566 @default.
- W2172017171 creator A5083969051 @default.
- W2172017171 creator A5084250686 @default.
- W2172017171 date "2015-08-12" @default.
- W2172017171 modified "2023-09-28" @default.
- W2172017171 title "Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6" @default.
- W2172017171 cites W1487101581 @default.
- W2172017171 cites W1544472757 @default.
- W2172017171 cites W1563646381 @default.
- W2172017171 cites W1566926046 @default.
- W2172017171 cites W1577555309 @default.
- W2172017171 cites W1659018739 @default.
- W2172017171 cites W1965871996 @default.
- W2172017171 cites W1968758858 @default.
- W2172017171 cites W1971849554 @default.
- W2172017171 cites W1994829764 @default.
- W2172017171 cites W2002451995 @default.
- W2172017171 cites W2004067791 @default.
- W2172017171 cites W2009074857 @default.
- W2172017171 cites W2009859686 @default.
- W2172017171 cites W2010090099 @default.
- W2172017171 cites W2012069333 @default.
- W2172017171 cites W2013921517 @default.
- W2172017171 cites W2014539288 @default.
- W2172017171 cites W2016844693 @default.
- W2172017171 cites W2020303255 @default.
- W2172017171 cites W2021622075 @default.
- W2172017171 cites W2026623158 @default.
- W2172017171 cites W2034528584 @default.
- W2172017171 cites W2035523654 @default.
- W2172017171 cites W2038976543 @default.
- W2172017171 cites W2046801956 @default.
- W2172017171 cites W2048131815 @default.
- W2172017171 cites W2052133198 @default.
- W2172017171 cites W2057364922 @default.
- W2172017171 cites W2057877742 @default.
- W2172017171 cites W2064837609 @default.
- W2172017171 cites W2065292885 @default.
- W2172017171 cites W2065338955 @default.
- W2172017171 cites W2065607560 @default.
- W2172017171 cites W2078374613 @default.
- W2172017171 cites W2081613377 @default.
- W2172017171 cites W2082871926 @default.
- W2172017171 cites W2086601270 @default.
- W2172017171 cites W2088595695 @default.
- W2172017171 cites W2091412272 @default.
- W2172017171 cites W2097029995 @default.
- W2172017171 cites W2097289038 @default.
- W2172017171 cites W2100577879 @default.
- W2172017171 cites W2102312699 @default.
- W2172017171 cites W2104843614 @default.
- W2172017171 cites W2105783298 @default.
- W2172017171 cites W2111022239 @default.
- W2172017171 cites W2113929556 @default.
- W2172017171 cites W2116558079 @default.
- W2172017171 cites W2118138896 @default.
- W2172017171 cites W2118767323 @default.
- W2172017171 cites W2120277258 @default.
- W2172017171 cites W2124785173 @default.
- W2172017171 cites W2126928586 @default.
- W2172017171 cites W2130128281 @default.
- W2172017171 cites W2130565734 @default.
- W2172017171 cites W2133964489 @default.
- W2172017171 cites W2134342374 @default.
- W2172017171 cites W2134595672 @default.
- W2172017171 cites W2134997949 @default.
- W2172017171 cites W2135135005 @default.
- W2172017171 cites W2137167381 @default.
- W2172017171 cites W2137688247 @default.
- W2172017171 cites W2138609584 @default.
- W2172017171 cites W2143253904 @default.
- W2172017171 cites W2143660712 @default.
- W2172017171 cites W2145369044 @default.
- W2172017171 cites W2146604395 @default.
- W2172017171 cites W2146607274 @default.
- W2172017171 cites W2147707256 @default.
- W2172017171 cites W2148078801 @default.
- W2172017171 cites W2148675722 @default.
- W2172017171 cites W2150430014 @default.
- W2172017171 cites W2151962109 @default.
- W2172017171 cites W2152348310 @default.
- W2172017171 cites W2153598858 @default.
- W2172017171 cites W2158332155 @default.
- W2172017171 cites W2159705346 @default.
- W2172017171 cites W2161032788 @default.
- W2172017171 cites W2163739493 @default.
- W2172017171 cites W2164290683 @default.
- W2172017171 cites W2170090299 @default.
- W2172017171 cites W2170421654 @default.
- W2172017171 cites W2170873039 @default.