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- W2172029282 abstract "Pharmacologic management of attention-deficit/hyperactivity disorder (ADHD) has expanded beyond stimulant medications to include α-2 adrenergic agonists. These agents exert their actions through presynaptic stimulation and likely involve facilitation of dopamine and noradrenaline neurotransmission, both of which are thought to play critical roles in the pathophysiology of ADHD. Furthermore, frontostriatal dysfunction giving rise to neuropsychological weaknesses has been well-established in patients with ADHD and may explain how α-2 agents exert their beneficial effects. In the following review, we consider relevant neurobiological underpinnings of ADHD with respect to why α-2 agents may be effective in treating this condition. We also review new formulations of α-2 agonists, emerging data on their use in ADHD, and implications for clinical practice. Integrating knowledge of pathophysiologic mechanisms and mechanisms of drug action may inform our medication choices and facilitate treatment of ADHD and related disorders." @default.
- W2172029282 created "2016-06-24" @default.
- W2172029282 creator A5068191739 @default.
- W2172029282 creator A5069525983 @default.
- W2172029282 creator A5071799984 @default.
- W2172029282 date "2010-07-23" @default.
- W2172029282 modified "2023-09-25" @default.
- W2172029282 title "Alpha-2 Adrenergic Receptors and Attention-Deficit/Hyperactivity Disorder" @default.
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- W2172029282 doi "https://doi.org/10.1007/s11920-010-0136-4" @default.
- W2172029282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3676929" @default.
- W2172029282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21136308" @default.
- W2172029282 hasPublicationYear "2010" @default.
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