FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172064361> ?p ?o ?g. }

• W2172064361 endingPage "11" @default.
• W2172064361 startingPage "1" @default.
• W2172064361 abstract "Respiratory function of mitochondria is compromised in aging human tissues and severely impaired in the patients with mitochondrial disease. A wide spectrum of mitochondrial DNA (mtDNA) mutations has been established to associate with mitochondrial diseases. Some of these mtDNA mutations also occur in various human tissues in an age-dependent manner. These mtDNA mutations cause defects in the respiratory chain due to impairment of the gene expression and structure of respiratory chain polypeptides that are encoded by the mitochondrial genome. Since defective mitochondria generate more reactive oxygen species (ROS) such as O2- and H2O2 via electron leak, we hypothesized that oxidative stress is a contributory factor for aging and mitochondrial disease. This hypothesis has been supported by the findings that oxidative stress and oxidative damage in tissues and culture cells are increased in elderly subjects and patients with mitochondrial diseases. Another line of supporting evidence is our recent finding that the enzyme activities of Cu,Zn-SOD, catalase and glutathione peroxidase (GPx) decrease with age in skin fibroblasts. By contrast, Mn-SOD activity increases up to 65 years of age and then slightly declines thereafter. On the other hand, we observed that the RNA, protein and activity levels of Mn-SOD are increased two- to three-fold in skin fibroblasts of the patients with CPEO syndrome but are dramatically decreased in patients with MELAS or MERRF syndrome. However, the other antioxidant enzymes did not change in the same manner. The imbalance in the expression of these antioxidant enzymes indicates that the production of ROS is in excess of their removal, which in turn may elicit an elevation of oxidative stress in the fibroblasts. Indeed, it was found that intracellular levels of H2O2 and oxidative damage to DNA and lipids in skin fibroblasts from elderly subjects or patients with mitochondrial diseases are significantly increased as compared to those of age-matched controls. Furthermore, Mn-SOD or GPx-1 gene knockout mice were found to display neurological disorders and enhanced oxidative damage similar to those observed in the patients with mitochondrial disease. These observations are reviewed in this article to support that oxidative stress elicited by defective respiratory function and impaired antioxidant enzyme system plays a key role in the pathophysiology of mitochondrial disease and human aging." @default.
• W2172064361 created "2016-06-24" @default.
• W2172064361 creator A5011337424 @default.
• W2172064361 creator A5014475279 @default.
• W2172064361 creator A5049330573 @default.
• W2172064361 creator A5049660274 @default.
• W2172064361 creator A5082381379 @default.
• W2172064361 date "2001-03-31" @default.
• W2172064361 modified "2023-09-29" @default.
• W2172064361 title "Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system." @default.
• W2172064361 cites W1480833135 @default.
• W2172064361 cites W1509408588 @default.
• W2172064361 cites W1509595973 @default.
• W2172064361 cites W1550759338 @default.
• W2172064361 cites W1925799544 @default.
• W2172064361 cites W1950372811 @default.
• W2172064361 cites W1964879817 @default.
• W2172064361 cites W1965278340 @default.
• W2172064361 cites W1969789360 @default.
• W2172064361 cites W1976689117 @default.
• W2172064361 cites W1979006721 @default.
• W2172064361 cites W1979796397 @default.
• W2172064361 cites W1982544552 @default.
• W2172064361 cites W1983642028 @default.
• W2172064361 cites W1987462314 @default.
• W2172064361 cites W1988369476 @default.
• W2172064361 cites W1989621117 @default.
• W2172064361 cites W1989912623 @default.
• W2172064361 cites W1993699862 @default.
• W2172064361 cites W1995110990 @default.
• W2172064361 cites W1997912585 @default.
• W2172064361 cites W2002860741 @default.
• W2172064361 cites W2003070223 @default.
• W2172064361 cites W2006550189 @default.
• W2172064361 cites W2008117286 @default.
• W2172064361 cites W2008431838 @default.
• W2172064361 cites W2009688381 @default.
• W2172064361 cites W2010094123 @default.
• W2172064361 cites W2014007422 @default.
• W2172064361 cites W2016163301 @default.
• W2172064361 cites W2018185503 @default.
• W2172064361 cites W2024672368 @default.
• W2172064361 cites W2025907197 @default.
• W2172064361 cites W2026538901 @default.
• W2172064361 cites W2027262563 @default.
• W2172064361 cites W2035966581 @default.
• W2172064361 cites W2036901477 @default.
• W2172064361 cites W2037542399 @default.
• W2172064361 cites W2037717843 @default.
• W2172064361 cites W2038811853 @default.
• W2172064361 cites W2039950693 @default.
• W2172064361 cites W2040394136 @default.
• W2172064361 cites W2042138106 @default.
• W2172064361 cites W2044494908 @default.
• W2172064361 cites W2045358555 @default.
• W2172064361 cites W2045409504 @default.
• W2172064361 cites W2048339025 @default.
• W2172064361 cites W2048966030 @default.
• W2172064361 cites W2050303681 @default.
• W2172064361 cites W2050454564 @default.
• W2172064361 cites W2054730971 @default.
• W2172064361 cites W2057162464 @default.
• W2172064361 cites W2057951424 @default.
• W2172064361 cites W2060363769 @default.
• W2172064361 cites W2066250257 @default.
• W2172064361 cites W2066461799 @default.
• W2172064361 cites W2068568687 @default.
• W2172064361 cites W2068674525 @default.
• W2172064361 cites W2073159120 @default.
• W2172064361 cites W2074303856 @default.
• W2172064361 cites W2074473663 @default.
• W2172064361 cites W2074946394 @default.
• W2172064361 cites W2075685752 @default.
• W2172064361 cites W2076510866 @default.
• W2172064361 cites W2077414996 @default.
• W2172064361 cites W2077694841 @default.
• W2172064361 cites W2079472889 @default.
• W2172064361 cites W2083326631 @default.
• W2172064361 cites W2083345303 @default.
• W2172064361 cites W2084255431 @default.
• W2172064361 cites W2086896876 @default.
• W2172064361 cites W2087432006 @default.
• W2172064361 cites W2087777085 @default.
• W2172064361 cites W2088683052 @default.
• W2172064361 cites W2092551351 @default.
• W2172064361 cites W2092895723 @default.
• W2172064361 cites W2093596543 @default.
• W2172064361 cites W2094521844 @default.
• W2172064361 cites W2094655287 @default.
• W2172064361 cites W2101861123 @default.
• W2172064361 cites W2104018711 @default.
• W2172064361 cites W2106894479 @default.
• W2172064361 cites W2113279188 @default.
• W2172064361 cites W2115505412 @default.
• W2172064361 cites W2119219029 @default.
• W2172064361 cites W2128533042 @default.
• W2172064361 cites W2130753450 @default.
• W2172064361 cites W2131461587 @default.

• next