Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172065100> ?p ?o ?g. }
- W2172065100 endingPage "1354" @default.
- W2172065100 startingPage "1345" @default.
- W2172065100 abstract "Limited pools of resident adult stem cells are critical effectors of epithelial renewal in the intestine throughout life. Recently, significant progress has been made regarding the isolation and in vitro propagation of fetal and adult intestinal stem cells in mammals. It is now possible to generate ever-expanding, three-dimensional epithelial structures in culture that closely parallel the in vivo epithelium of the intestine. Growing such organotypic epithelium ex vivo facilitates a detailed description of endogenous niche factors or stem-cell characteristics, as they can be monitored in real time. Accordingly, this technology has already greatly contributed to our understanding of intestinal adult stem-cell renewal and differentiation. Transplanted organoids have also been proven to readily integrate into, and effect the long-term repair of, mouse colonic epithelia in vivo, establishing the organoid culture as a promising tool for adult stem cell/gene therapy. In another exciting development, novel genome-editing techniques have been successfully employed to functionally repair disease loci in cultured intestinal stem cells from human patients with a hereditary defect. It is anticipated that this technology will be instrumental in exploiting the regenerative medicine potential of human intestinal stem cells for treating human disorders in the intestinal tract and for creating near-physiological ex vivo models of human gastrointestinal disease." @default.
- W2172065100 created "2016-06-24" @default.
- W2172065100 creator A5039644515 @default.
- W2172065100 creator A5073963216 @default.
- W2172065100 date "2014-05-19" @default.
- W2172065100 modified "2023-10-18" @default.
- W2172065100 title "Ex vivo culture of the intestinal epithelium: strategies and applications" @default.
- W2172065100 cites W1517051009 @default.
- W2172065100 cites W1574718766 @default.
- W2172065100 cites W1872893154 @default.
- W2172065100 cites W1873188727 @default.
- W2172065100 cites W1874198492 @default.
- W2172065100 cites W1964287957 @default.
- W2172065100 cites W1965157206 @default.
- W2172065100 cites W1971163936 @default.
- W2172065100 cites W1978129709 @default.
- W2172065100 cites W1979440527 @default.
- W2172065100 cites W1981068608 @default.
- W2172065100 cites W1982603620 @default.
- W2172065100 cites W1986316308 @default.
- W2172065100 cites W1988903229 @default.
- W2172065100 cites W1990796754 @default.
- W2172065100 cites W1994216131 @default.
- W2172065100 cites W1995060691 @default.
- W2172065100 cites W1997114875 @default.
- W2172065100 cites W1998536076 @default.
- W2172065100 cites W2002513358 @default.
- W2172065100 cites W2003299661 @default.
- W2172065100 cites W2006419043 @default.
- W2172065100 cites W2007662760 @default.
- W2172065100 cites W2008285918 @default.
- W2172065100 cites W2009756725 @default.
- W2172065100 cites W2014956339 @default.
- W2172065100 cites W2017828716 @default.
- W2172065100 cites W2018602900 @default.
- W2172065100 cites W2029556699 @default.
- W2172065100 cites W2037153840 @default.
- W2172065100 cites W2038714514 @default.
- W2172065100 cites W2042423362 @default.
- W2172065100 cites W2043915076 @default.
- W2172065100 cites W2044022855 @default.
- W2172065100 cites W2045435533 @default.
- W2172065100 cites W2046409965 @default.
- W2172065100 cites W2047032063 @default.
- W2172065100 cites W2047151533 @default.
- W2172065100 cites W2047450548 @default.
- W2172065100 cites W2056873984 @default.
- W2172065100 cites W2060515414 @default.
- W2172065100 cites W2061965920 @default.
- W2172065100 cites W2062004524 @default.
- W2172065100 cites W2062909560 @default.
- W2172065100 cites W2066362124 @default.
- W2172065100 cites W2069962068 @default.
- W2172065100 cites W2072965356 @default.
- W2172065100 cites W2078308455 @default.
- W2172065100 cites W2079356804 @default.
- W2172065100 cites W2080157242 @default.
- W2172065100 cites W2089044039 @default.
- W2172065100 cites W2090789702 @default.
- W2172065100 cites W2094191556 @default.
- W2172065100 cites W2094935750 @default.
- W2172065100 cites W2097387056 @default.
- W2172065100 cites W2101095306 @default.
- W2172065100 cites W2104081204 @default.
- W2172065100 cites W2104176068 @default.
- W2172065100 cites W2110537190 @default.
- W2172065100 cites W2111724542 @default.
- W2172065100 cites W2113486346 @default.
- W2172065100 cites W2114881954 @default.
- W2172065100 cites W2119059014 @default.
- W2172065100 cites W2119578188 @default.
- W2172065100 cites W2120382735 @default.
- W2172065100 cites W2121998033 @default.
- W2172065100 cites W2123746851 @default.
- W2172065100 cites W2125806967 @default.
- W2172065100 cites W2129781547 @default.
- W2172065100 cites W2133899877 @default.
- W2172065100 cites W2138224451 @default.
- W2172065100 cites W2141915435 @default.
- W2172065100 cites W2143149122 @default.
- W2172065100 cites W2143296478 @default.
- W2172065100 cites W2143973293 @default.
- W2172065100 cites W2144283689 @default.
- W2172065100 cites W2145955680 @default.
- W2172065100 cites W2148625728 @default.
- W2172065100 cites W2151829259 @default.
- W2172065100 cites W2153344788 @default.
- W2172065100 cites W2153618863 @default.
- W2172065100 cites W2155170442 @default.
- W2172065100 cites W2157010562 @default.
- W2172065100 cites W2159155233 @default.
- W2172065100 cites W2168901267 @default.
- W2172065100 cites W2171977041 @default.
- W2172065100 cites W4292198229 @default.
- W2172065100 doi "https://doi.org/10.1136/gutjnl-2014-307204" @default.
- W2172065100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24841573" @default.
- W2172065100 hasPublicationYear "2014" @default.
- W2172065100 type Work @default.