Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172073506> ?p ?o ?g. }
- W2172073506 endingPage "e75556" @default.
- W2172073506 startingPage "e75556" @default.
- W2172073506 abstract "Background Rhesus macaques (RMs) inoculated with live-attenuated Rev-Independent Nef¯ simian immunodeficiency virus (Rev-Ind Nef¯SIV) as adults or neonates controlled viremia to undetectable levels and showed no signs of immunodeficiency over 6-8 years of follow-up. We tested the capacity of this live-attenuated virus to protect RMs against pathogenic, heterologous SIVsmE660 challenges. Methodology/Principal Findings Three groups of four RM were inoculated with Rev-Ind Nef¯SIV and compared. Group 1 was inoculated 8 years prior and again 15 months before low dose intrarectal challenges with SIVsmE660. Group 2 animals were inoculated with Rev-Ind Nef¯SIV at 15 months and Group 3 at 2 weeks prior to the SIVsmE660 challenges, respectively. Group 4 served as unvaccinated controls. All RMs underwent repeated weekly low-dose intrarectal challenges with SIVsmE660. Surprisingly, all RMs with acute live-attenuated virus infection (Group 3) became superinfected with the challenge virus, in contrast to the two other vaccine groups (Groups 1 and 2) (P=0.006 for each) and controls (Group 4) (P=0.022). Gene expression analysis showed significant upregulation of innate immune response-related chemokines and their receptors, most notably CCR5 in Group 3 animals during acute infection with Rev-Ind Nef¯SIV. Conclusions/Significance We conclude that although Rev-Ind Nef¯SIV remained apathogenic, acute replication of the vaccine strain was not protective but associated with increased acquisition of heterologous mucosal SIVsmE660 challenges." @default.
- W2172073506 created "2016-06-24" @default.
- W2172073506 creator A5003601504 @default.
- W2172073506 creator A5026242578 @default.
- W2172073506 creator A5041763125 @default.
- W2172073506 creator A5042667397 @default.
- W2172073506 creator A5051157099 @default.
- W2172073506 creator A5051562000 @default.
- W2172073506 creator A5065490907 @default.
- W2172073506 creator A5068540949 @default.
- W2172073506 creator A5069687616 @default.
- W2172073506 creator A5087925525 @default.
- W2172073506 creator A5089399444 @default.
- W2172073506 date "2013-09-30" @default.
- W2172073506 modified "2023-10-14" @default.
- W2172073506 title "Live Attenuated Rev-Independent Nef¯SIV Enhances Acquisition of Heterologous SIVsmE660 in Acutely Vaccinated Rhesus Macaques" @default.
- W2172073506 cites W1542764499 @default.
- W2172073506 cites W1581487975 @default.
- W2172073506 cites W1586015366 @default.
- W2172073506 cites W1838210676 @default.
- W2172073506 cites W1980199406 @default.
- W2172073506 cites W1980723592 @default.
- W2172073506 cites W1981459523 @default.
- W2172073506 cites W1985666662 @default.
- W2172073506 cites W1988379994 @default.
- W2172073506 cites W1992358907 @default.
- W2172073506 cites W1997844185 @default.
- W2172073506 cites W1998668189 @default.
- W2172073506 cites W2000688451 @default.
- W2172073506 cites W2009369926 @default.
- W2172073506 cites W2009748550 @default.
- W2172073506 cites W2009960465 @default.
- W2172073506 cites W2025481552 @default.
- W2172073506 cites W2034100391 @default.
- W2172073506 cites W2035570649 @default.
- W2172073506 cites W2036479803 @default.
- W2172073506 cites W2038546836 @default.
- W2172073506 cites W2047862752 @default.
- W2172073506 cites W2051926684 @default.
- W2172073506 cites W2054395379 @default.
- W2172073506 cites W2056478255 @default.
- W2172073506 cites W2060738148 @default.
- W2172073506 cites W2063337740 @default.
- W2172073506 cites W2066803746 @default.
- W2172073506 cites W2074274250 @default.
- W2172073506 cites W2077348914 @default.
- W2172073506 cites W2078936177 @default.
- W2172073506 cites W2083512827 @default.
- W2172073506 cites W2091961542 @default.
- W2172073506 cites W2095651361 @default.
- W2172073506 cites W2098657635 @default.
- W2172073506 cites W2108166421 @default.
- W2172073506 cites W2109780373 @default.
- W2172073506 cites W2109972881 @default.
- W2172073506 cites W2112852315 @default.
- W2172073506 cites W2128772322 @default.
- W2172073506 cites W2130320631 @default.
- W2172073506 cites W2140027694 @default.
- W2172073506 cites W2150249219 @default.
- W2172073506 cites W2153670011 @default.
- W2172073506 cites W2155818154 @default.
- W2172073506 cites W2156076060 @default.
- W2172073506 cites W2156411630 @default.
- W2172073506 cites W2160697532 @default.
- W2172073506 cites W2161157573 @default.
- W2172073506 cites W2162187516 @default.
- W2172073506 cites W2162478418 @default.
- W2172073506 cites W2162891851 @default.
- W2172073506 cites W2170297639 @default.
- W2172073506 cites W2175273487 @default.
- W2172073506 cites W2321998793 @default.
- W2172073506 cites W2336069963 @default.
- W2172073506 cites W4230331073 @default.
- W2172073506 cites W4239379492 @default.
- W2172073506 cites W45534775 @default.
- W2172073506 doi "https://doi.org/10.1371/journal.pone.0075556" @default.
- W2172073506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3787041" @default.
- W2172073506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24098702" @default.
- W2172073506 hasPublicationYear "2013" @default.
- W2172073506 type Work @default.
- W2172073506 sameAs 2172073506 @default.
- W2172073506 citedByCount "7" @default.
- W2172073506 countsByYear W21720735062014 @default.
- W2172073506 countsByYear W21720735062016 @default.
- W2172073506 countsByYear W21720735062017 @default.
- W2172073506 countsByYear W21720735062018 @default.
- W2172073506 countsByYear W21720735062019 @default.
- W2172073506 countsByYear W21720735062020 @default.
- W2172073506 crossrefType "journal-article" @default.
- W2172073506 hasAuthorship W2172073506A5003601504 @default.
- W2172073506 hasAuthorship W2172073506A5026242578 @default.
- W2172073506 hasAuthorship W2172073506A5041763125 @default.
- W2172073506 hasAuthorship W2172073506A5042667397 @default.
- W2172073506 hasAuthorship W2172073506A5051157099 @default.
- W2172073506 hasAuthorship W2172073506A5051562000 @default.
- W2172073506 hasAuthorship W2172073506A5065490907 @default.
- W2172073506 hasAuthorship W2172073506A5068540949 @default.
- W2172073506 hasAuthorship W2172073506A5069687616 @default.