FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172080356> ?p ?o ?g. }

• W2172080356 abstract "Polycystic ovary syndrome (PCOS) is one of the most common reproductive disorders in women. Previous studies have shown that prenatal exposure of female fetuses to androgen can be considered an important factor in the development of PCOS.In the present study we aimed to examine the effects of prenatal exposure of female rat fetuses to previously documented doses of testosterone on different embryonic days on the development of PCOS phenotype in adulthood.Pregnant rats were divided into four groups, experimental and control groups. Three mg of free testosterone was administered subcutaneously to experimental group 1 on gestational days 16-19, daily and 20 mg on day 20, to experimental group 2, and the controls received solvent at the same times. Female offspring of these mothers aged between 90-100 days were examined for development and function of the reproductive system. Independent-sample student t test was used to compare the results between the experimental groups and controls.Anogenital distance (P < 0.001) and clitoris length were significantly increased in the offspring of both experimental groups (P < 0.001 and P < 0.05 respectively). Nipples were not formed in the offspring of experimental group 1, whereas in experimental group 2 the number of nipples was unchanged. Vaginal length was significantly decreased in the offspring of experimental group 1 (P < 0.001), whereas in experimental group 2, no significant difference was observed. In the offspring of experimental group 1, hormonal profiles did not differ, but in experimental group 2, levels of testosterone (P < 0.05) and LH (P < 0.01) were significantly increased, but estrogen (P < 0.05) and anti-Mullerian hormone levels (P < 0.001) were significantly decreased. A significant increase in the number of preantral and antral follicles was observed in the ovaries of offspring of experimental group 1 (P < 0.05); whereas there was no such a difference in experimental group 2.The time of prenatal exposure to androgens may have a significant role in the development of PCOS. Increased prenatal androgen levels are associated with hormonal changes and morphological disorders of the reproductive system. Therefore, avoiding exposure to androgen excess during critical periods of fetal development may prevent or reduce adulthood PCOS manifestations caused by prenatal excess androgen." @default.
• W2172080356 created "2016-06-24" @default.
• W2172080356 creator A5037842594 @default.
• W2172080356 creator A5043112519 @default.
• W2172080356 creator A5043274150 @default.
• W2172080356 creator A5050671463 @default.
• W2172080356 creator A5069440712 @default.
• W2172080356 creator A5080500381 @default.
• W2172080356 date "2014-04-01" @default.
• W2172080356 modified "2023-10-03" @default.
• W2172080356 title "The Time of Prenatal Androgen Exposure Affects Development of Polycystic Ovary Syndrome-Like Phenotype in Adulthood in Female Rats" @default.
• W2172080356 cites W1787242015 @default.
• W2172080356 cites W1898114459 @default.
• W2172080356 cites W1900119753 @default.
• W2172080356 cites W1972260789 @default.
• W2172080356 cites W1983183763 @default.
• W2172080356 cites W2002553752 @default.
• W2172080356 cites W2003113589 @default.
• W2172080356 cites W2008493497 @default.
• W2172080356 cites W2017989931 @default.
• W2172080356 cites W2021699750 @default.
• W2172080356 cites W2026854030 @default.
• W2172080356 cites W2039410885 @default.
• W2172080356 cites W2040115176 @default.
• W2172080356 cites W2040600141 @default.
• W2172080356 cites W2046126188 @default.
• W2172080356 cites W2049446985 @default.
• W2172080356 cites W2061783211 @default.
• W2172080356 cites W2063008992 @default.
• W2172080356 cites W2065284917 @default.
• W2172080356 cites W2067351281 @default.
• W2172080356 cites W2069577578 @default.
• W2172080356 cites W2078094750 @default.
• W2172080356 cites W2089211374 @default.
• W2172080356 cites W2096353246 @default.
• W2172080356 cites W2098312837 @default.
• W2172080356 cites W2101974080 @default.
• W2172080356 cites W2104549611 @default.
• W2172080356 cites W2114277230 @default.
• W2172080356 cites W2114291118 @default.
• W2172080356 cites W2123009569 @default.
• W2172080356 cites W2123076937 @default.
• W2172080356 cites W2123874077 @default.
• W2172080356 cites W2125121954 @default.
• W2172080356 cites W2126836250 @default.
• W2172080356 cites W2142850318 @default.
• W2172080356 cites W2154467569 @default.
• W2172080356 cites W2157268169 @default.
• W2172080356 cites W2157390106 @default.
• W2172080356 cites W2160136963 @default.
• W2172080356 cites W2163961809 @default.
• W2172080356 cites W2397344358 @default.
• W2172080356 doi "https://doi.org/10.5812/ijem.16502" @default.
• W2172080356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4030220" @default.
• W2172080356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24910644" @default.
• W2172080356 hasPublicationYear "2014" @default.
• W2172080356 type Work @default.
• W2172080356 sameAs 2172080356 @default.
• W2172080356 citedByCount "28" @default.
• W2172080356 countsByYear W21720803562013 @default.
• W2172080356 countsByYear W21720803562015 @default.
• W2172080356 countsByYear W21720803562016 @default.
• W2172080356 countsByYear W21720803562017 @default.
• W2172080356 countsByYear W21720803562018 @default.
• W2172080356 countsByYear W21720803562019 @default.
• W2172080356 countsByYear W21720803562020 @default.
• W2172080356 countsByYear W21720803562021 @default.
• W2172080356 countsByYear W21720803562022 @default.
• W2172080356 countsByYear W21720803562023 @default.
• W2172080356 crossrefType "journal-article" @default.
• W2172080356 hasAuthorship W2172080356A5037842594 @default.
• W2172080356 hasAuthorship W2172080356A5043112519 @default.
• W2172080356 hasAuthorship W2172080356A5043274150 @default.
• W2172080356 hasAuthorship W2172080356A5050671463 @default.
• W2172080356 hasAuthorship W2172080356A5069440712 @default.
• W2172080356 hasAuthorship W2172080356A5080500381 @default.
• W2172080356 hasBestOaLocation W21720803561 @default.
• W2172080356 hasConcept C112672928 @default.
• W2172080356 hasConcept C126322002 @default.
• W2172080356 hasConcept C134018914 @default.
• W2172080356 hasConcept C172680121 @default.
• W2172080356 hasConcept C2777391703 @default.
• W2172080356 hasConcept C2777911890 @default.
• W2172080356 hasConcept C2778324911 @default.
• W2172080356 hasConcept C2779234561 @default.
• W2172080356 hasConcept C2779279991 @default.
• W2172080356 hasConcept C3018442814 @default.
• W2172080356 hasConcept C42407357 @default.
• W2172080356 hasConcept C511355011 @default.
• W2172080356 hasConcept C54355233 @default.
• W2172080356 hasConcept C71315377 @default.
• W2172080356 hasConcept C71924100 @default.
• W2172080356 hasConcept C86803240 @default.
• W2172080356 hasConceptScore W2172080356C112672928 @default.
• W2172080356 hasConceptScore W2172080356C126322002 @default.
• W2172080356 hasConceptScore W2172080356C134018914 @default.
• W2172080356 hasConceptScore W2172080356C172680121 @default.
• W2172080356 hasConceptScore W2172080356C2777391703 @default.
• W2172080356 hasConceptScore W2172080356C2777911890 @default.
• W2172080356 hasConceptScore W2172080356C2778324911 @default.

• next