Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172086940> ?p ?o ?g. }
- W2172086940 endingPage "9" @default.
- W2172086940 startingPage "1" @default.
- W2172086940 abstract "In this work, we have evaluated the effect of the new discovered peptide obestatin on cell proliferation in primary cultures of human retinal epithelial cells (hRPE cells). The results showed that this peptide induced, in a dose-dependent manner, cell proliferation by MEK/ERK 1/2 phosphorylation. A sequential analysis of the obestatin transmembrane signaling pathway showed that the ERK 1/2 activity is partially blocked after preincubation of the cells with pertussis toxin (PTX), as well as by wortmannin (an inhibitor of PI3K), claphostin C (an inhibitor of PKC), and PP2 (which inhibits the non receptor tyrosine kinase Src). Upon administration of obestatin, the intracellular levels of phospho-PKCε-, θ-, and µ-isoenzymes rise with different time courses, from which PKCε might be responsible for ERK 1/2 response. Based on the experimental data, a signaling pathway involving the consecutive activation of Gi, PI3K, novel PKC (probably PKCε), and Src for ERK 1/2 activation is proposed. These results incorporate a new mitogenic factor to the group of factors that regulate proliferation of hRPE cells. J. Cell. Physiol. 211: 1–9, 2007. © 2006 Wiley-Liss, Inc." @default.
- W2172086940 created "2016-06-24" @default.
- W2172086940 creator A5004415273 @default.
- W2172086940 creator A5020837316 @default.
- W2172086940 creator A5032467307 @default.
- W2172086940 creator A5044168126 @default.
- W2172086940 creator A5089487971 @default.
- W2172086940 date "2007-01-01" @default.
- W2172086940 modified "2023-10-03" @default.
- W2172086940 title "Obestatin-mediated proliferation of human retinal pigment epithelial cells: Regulatory mechanisms" @default.
- W2172086940 cites W1643628872 @default.
- W2172086940 cites W1655327195 @default.
- W2172086940 cites W1836215938 @default.
- W2172086940 cites W1964164128 @default.
- W2172086940 cites W1966740850 @default.
- W2172086940 cites W1967319778 @default.
- W2172086940 cites W1979990310 @default.
- W2172086940 cites W1990454918 @default.
- W2172086940 cites W1992159395 @default.
- W2172086940 cites W1995125071 @default.
- W2172086940 cites W2000824954 @default.
- W2172086940 cites W2002514583 @default.
- W2172086940 cites W2007232482 @default.
- W2172086940 cites W2009387204 @default.
- W2172086940 cites W2009857536 @default.
- W2172086940 cites W2009935013 @default.
- W2172086940 cites W2011792786 @default.
- W2172086940 cites W2018126880 @default.
- W2172086940 cites W2018817522 @default.
- W2172086940 cites W2025067667 @default.
- W2172086940 cites W2025699735 @default.
- W2172086940 cites W2029253559 @default.
- W2172086940 cites W2031039608 @default.
- W2172086940 cites W2034691869 @default.
- W2172086940 cites W2037328290 @default.
- W2172086940 cites W2037733562 @default.
- W2172086940 cites W2041747549 @default.
- W2172086940 cites W2047258533 @default.
- W2172086940 cites W2051152907 @default.
- W2172086940 cites W2053551157 @default.
- W2172086940 cites W2061673720 @default.
- W2172086940 cites W2066652827 @default.
- W2172086940 cites W2070696872 @default.
- W2172086940 cites W2072198264 @default.
- W2172086940 cites W2074222374 @default.
- W2172086940 cites W2085698651 @default.
- W2172086940 cites W2088166206 @default.
- W2172086940 cites W2108193919 @default.
- W2172086940 cites W2125762952 @default.
- W2172086940 cites W2133816760 @default.
- W2172086940 cites W2134064618 @default.
- W2172086940 cites W2159953124 @default.
- W2172086940 cites W2169665295 @default.
- W2172086940 cites W261919997 @default.
- W2172086940 cites W4233391937 @default.
- W2172086940 cites W74158845 @default.
- W2172086940 doi "https://doi.org/10.1002/jcp.20925" @default.
- W2172086940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17186496" @default.
- W2172086940 hasPublicationYear "2007" @default.
- W2172086940 type Work @default.
- W2172086940 sameAs 2172086940 @default.
- W2172086940 citedByCount "68" @default.
- W2172086940 countsByYear W21720869402012 @default.
- W2172086940 countsByYear W21720869402013 @default.
- W2172086940 countsByYear W21720869402014 @default.
- W2172086940 countsByYear W21720869402015 @default.
- W2172086940 countsByYear W21720869402016 @default.
- W2172086940 countsByYear W21720869402018 @default.
- W2172086940 countsByYear W21720869402019 @default.
- W2172086940 crossrefType "journal-article" @default.
- W2172086940 hasAuthorship W2172086940A5004415273 @default.
- W2172086940 hasAuthorship W2172086940A5020837316 @default.
- W2172086940 hasAuthorship W2172086940A5032467307 @default.
- W2172086940 hasAuthorship W2172086940A5044168126 @default.
- W2172086940 hasAuthorship W2172086940A5089487971 @default.
- W2172086940 hasConcept C108636557 @default.
- W2172086940 hasConcept C11960822 @default.
- W2172086940 hasConcept C185592680 @default.
- W2172086940 hasConcept C195794163 @default.
- W2172086940 hasConcept C2778308172 @default.
- W2172086940 hasConcept C42362537 @default.
- W2172086940 hasConcept C49773422 @default.
- W2172086940 hasConcept C55493867 @default.
- W2172086940 hasConcept C57074206 @default.
- W2172086940 hasConcept C62112901 @default.
- W2172086940 hasConcept C62478195 @default.
- W2172086940 hasConcept C80631254 @default.
- W2172086940 hasConcept C86554907 @default.
- W2172086940 hasConcept C86803240 @default.
- W2172086940 hasConcept C95444343 @default.
- W2172086940 hasConceptScore W2172086940C108636557 @default.
- W2172086940 hasConceptScore W2172086940C11960822 @default.
- W2172086940 hasConceptScore W2172086940C185592680 @default.
- W2172086940 hasConceptScore W2172086940C195794163 @default.
- W2172086940 hasConceptScore W2172086940C2778308172 @default.
- W2172086940 hasConceptScore W2172086940C42362537 @default.
- W2172086940 hasConceptScore W2172086940C49773422 @default.
- W2172086940 hasConceptScore W2172086940C55493867 @default.