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• W2172089659 abstract "Background: Teneligliptin is a novel, highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor. The aim of this study is to explore the glycemic and non-glycemic efficacies of teneligliptin as an initial therapy. Methods: Newly diagnosed, drug naive Japanese subjects with type 2 diabetes (T2DM) were assigned to 20 mg/day teneligliptin monotherapy (n = 31). At 3 months, levels of glycemic and other parameters were compared with those at baseline. Results: Significant reductions of HbA1c (from 10.34 ± 2.06 to 8.38 ± 2.23%) and fasting blood glucose (FGB, from 211.3 ± 68.4 to 167.3 ± 70.2 mg/dL) levels were observed without any clinically significant adverse events. However, significant increases of uric acids (UA) levels were observed and two subjects reported mild hypoglycemic events. Homeostasis model assessment-B (HOMA-B) levels significantly increased, while high HOMA-R levels significantly decreased. Significant correlations were observed between the changes ( delta ) of HbA1c and those of HOMA-B, and between delta FBG and delta HOMA-R. No changes in lipid and body weight were noted. Conclusions: Teneligliptin might be effectively and safely used as an initial therapy for newly diagnosed T2DM. Glycemic efficacy of teneligliptin is obtained through activating beta-cell function as well as decreasing insulin resistance. J Clin Med Res. 2014;6(4):287-294 doi: http://dx.doi.org/10.14740/jocmr1841e" @default.
• W2172089659 created "2016-06-24" @default.
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• W2172089659 date "2014-01-01" @default.
• W2172089659 modified "2023-09-27" @default.
• W2172089659 title "Teneligliptin As an Initial Therapy for Newly Diagnosed, Drug Naive Subjects With Type 2 Diabetes" @default.
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• W2172089659 doi "https://doi.org/10.14740/jocmr1841e" @default.
• W2172089659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4039101" @default.
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