FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172095074> ?p ?o ?g. }

• W2172095074 endingPage "6592" @default.
• W2172095074 startingPage "6581" @default.
• W2172095074 abstract "Allelic forms of DRG1/AFG2 confer resistance to the drug diazaborine, an inhibitor of ribosome biogenesis in Saccharomyces cerevisiae. Our results show that the AAA-ATPase Drg1 is essential for 60S maturation and associates with 60S precursor particles in the cytoplasm. Functional inactivation of Drg1 leads to an increased cytoplasmic localization of shuttling pre-60S maturation factors like Rlp24, Arx1, and Tif6. Surprisingly, Nog1, a nuclear pre-60S factor, was also relocalized to the cytoplasm under these conditions, suggesting that it is a previously unsuspected shuttling preribosomal factor that is exported with the precursor particles and very rapidly reimported. Proteins that became cytoplasmic under drg1 mutant conditions were blocked on pre-60S particles at a step that precedes the association of Rei1, a later-acting preribosomal factor. A similar cytoplasmic accumulation of Nog1 and Rlp24 in pre-60S-bound form could be seen after overexpression of a dominant-negative Drg1 variant mutated in the D2 ATPase domain. We conclude that the ATPase activity of Drg1 is required for the release of shuttling proteins from the pre-60S particles shortly after their nuclear export. This early cytoplasmic release reaction defines a novel step in eukaryotic ribosome maturation." @default.
• W2172095074 created "2016-06-24" @default.
• W2172095074 creator A5000130128 @default.
• W2172095074 creator A5011356825 @default.
• W2172095074 creator A5014324611 @default.
• W2172095074 creator A5024324455 @default.
• W2172095074 creator A5031494037 @default.
• W2172095074 creator A5042317792 @default.
• W2172095074 creator A5060510393 @default.
• W2172095074 creator A5063131075 @default.
• W2172095074 creator A5065533632 @default.
• W2172095074 creator A5074897495 @default.
• W2172095074 creator A5078340007 @default.
• W2172095074 creator A5084337876 @default.
• W2172095074 creator A5090152625 @default.
• W2172095074 date "2007-10-01" @default.
• W2172095074 modified "2023-10-18" @default.
• W2172095074 title "Cytoplasmic Recycling of 60S Preribosomal Factors Depends on the AAA Protein Drg1" @default.
• W2172095074 cites W1421420331 @default.
• W2172095074 cites W1575542444 @default.
• W2172095074 cites W1981515958 @default.
• W2172095074 cites W1981715749 @default.
• W2172095074 cites W2013947447 @default.
• W2172095074 cites W2018232440 @default.
• W2172095074 cites W2025960774 @default.
• W2172095074 cites W2036764500 @default.
• W2172095074 cites W2037055277 @default.
• W2172095074 cites W2037257931 @default.
• W2172095074 cites W2039461665 @default.
• W2172095074 cites W2041734491 @default.
• W2172095074 cites W2048903083 @default.
• W2172095074 cites W2049082688 @default.
• W2172095074 cites W2058904982 @default.
• W2172095074 cites W2059265460 @default.
• W2172095074 cites W2061044811 @default.
• W2172095074 cites W2063908091 @default.
• W2172095074 cites W2087926131 @default.
• W2172095074 cites W2105872071 @default.
• W2172095074 cites W2115630577 @default.
• W2172095074 cites W2119515698 @default.
• W2172095074 cites W2119605310 @default.
• W2172095074 cites W2121022376 @default.
• W2172095074 cites W2123779991 @default.
• W2172095074 cites W2126219914 @default.
• W2172095074 cites W2126431396 @default.
• W2172095074 cites W2126524332 @default.
• W2172095074 cites W2145823322 @default.
• W2172095074 cites W2146503498 @default.
• W2172095074 cites W2152322252 @default.
• W2172095074 cites W2154303981 @default.
• W2172095074 cites W2169805130 @default.
• W2172095074 cites W230451612 @default.
• W2172095074 cites W2314892444 @default.
• W2172095074 cites W4234287785 @default.
• W2172095074 cites W4245546812 @default.
• W2172095074 doi "https://doi.org/10.1128/mcb.00668-07" @default.
• W2172095074 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2099225" @default.
• W2172095074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17646390" @default.
• W2172095074 hasPublicationYear "2007" @default.
• W2172095074 type Work @default.
• W2172095074 sameAs 2172095074 @default.
• W2172095074 citedByCount "92" @default.
• W2172095074 countsByYear W21720950742012 @default.
• W2172095074 countsByYear W21720950742013 @default.
• W2172095074 countsByYear W21720950742014 @default.
• W2172095074 countsByYear W21720950742015 @default.
• W2172095074 countsByYear W21720950742016 @default.
• W2172095074 countsByYear W21720950742017 @default.
• W2172095074 countsByYear W21720950742018 @default.
• W2172095074 countsByYear W21720950742019 @default.
• W2172095074 countsByYear W21720950742020 @default.
• W2172095074 countsByYear W21720950742021 @default.
• W2172095074 countsByYear W21720950742022 @default.
• W2172095074 countsByYear W21720950742023 @default.
• W2172095074 crossrefType "journal-article" @default.
• W2172095074 hasAuthorship W2172095074A5000130128 @default.
• W2172095074 hasAuthorship W2172095074A5011356825 @default.
• W2172095074 hasAuthorship W2172095074A5014324611 @default.
• W2172095074 hasAuthorship W2172095074A5024324455 @default.
• W2172095074 hasAuthorship W2172095074A5031494037 @default.
• W2172095074 hasAuthorship W2172095074A5042317792 @default.
• W2172095074 hasAuthorship W2172095074A5060510393 @default.
• W2172095074 hasAuthorship W2172095074A5063131075 @default.
• W2172095074 hasAuthorship W2172095074A5065533632 @default.
• W2172095074 hasAuthorship W2172095074A5074897495 @default.
• W2172095074 hasAuthorship W2172095074A5078340007 @default.
• W2172095074 hasAuthorship W2172095074A5084337876 @default.
• W2172095074 hasAuthorship W2172095074A5090152625 @default.
• W2172095074 hasBestOaLocation W21720950741 @default.
• W2172095074 hasConcept C104317684 @default.
• W2172095074 hasConcept C153911025 @default.
• W2172095074 hasConcept C190062978 @default.
• W2172095074 hasConcept C2779419633 @default.
• W2172095074 hasConcept C55493867 @default.
• W2172095074 hasConcept C67705224 @default.
• W2172095074 hasConcept C86803240 @default.
• W2172095074 hasConcept C88478588 @default.
• W2172095074 hasConcept C95444343 @default.

• next