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• W2172102000 abstract "There has been considerable confusion relating to the basis for changes in brain function as we age. Is there an intrinsic aging process related to some biological deterioration of cellular integrity or connectivity within the brain? If brain aging occurs, how is it related to the major problems of dementia and Alzheimer's disease (AD)? Can we affect these processes by changes in our environment, diet, and physical activity, or by ensuring we continue to engage in demanding mental topics when we are older? This was the subject of the Marabou Trust meeting in 2009, attended by over 40 international experts. The meeting benefited from nine formal lectures, which are the basis for the papers in this symposium, together with a series of mini presentations and over 6 hours of interactive debate, all of which is summarized in the accompanying attributed discussion.Brain aging is characterized by the progressive and gradual accumulation over time of detrimental changes in structure and function. These changes increase the risk of dementia, which is a clinical syndrome involving multiple cognitive deficits that become severe enough to impair the affected person's ability to function effectively in either a social or professional manner.1 The two most common causes are AD and vascular dementia, but the two conditions interact and have synergistic effects on mental impairment in many individuals.The first issue is how best to assess brain aging. Should the focus be on a detailed series of functional tests in humans, an analysis of the anatomical and biochemical/physiological processing in the brain, or clinical studies of individuals affected by different diseases or perhaps by genetic abnormalities of neural function? Presumably, a comparative biological perspective on what happens in other animals and organisms might also help elucidate the possible intrinsic features of aging.In both experimental animals …" @default.
• W2172102000 created "2016-06-24" @default.
• W2172102000 creator A5064838278 @default.
• W2172102000 date "2010-11-23" @default.
• W2172102000 modified "2023-09-27" @default.
• W2172102000 title "23rd Marabou Symposium: Nutrition and the Aging Brain" @default.
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• W2172102000 doi "https://doi.org/10.1111/j.1753-4887.2010.00349.x" @default.
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