Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172109321> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2172109321 endingPage "3" @default.
- W2172109321 startingPage "3990" @default.
- W2172109321 abstract "We have studied the activity of recombinant human tumor necrosis factor (rHuTNF) on six different human tumor xenografts derived from primary breast and bowel tumors and maintained by passage in nude mice. When 5 micrograms rHuTNF was given daily intratumorally to mice with established (approximately, 0.5 cm) tumors, total tumor regression was observed by 3-4 weeks in three of six xenograft lines. In a further two lines tumor stasis or significant slowing of growth was seen. This antitumor action was not accompanied by any consistent macroscopic change in the tumor such as necrosis, but histological examination revealed tumor cell degeneration and a large peritumoral infiltration of host inflammatory cells after 4-7 days therapy. In contrast to these data, little effect was seen when the same dose of rHuTNF was administered i.p. to nude mice bearing these tumors. In only two of six lines was any significant slowing of tumor growth seen. A 5-fold increase in the i.p. dose resulted in improved activity on only one of two xenograft lines tested. Efficacy of the i.p. rHuTNF dose could, however, be enhanced by simultaneous administration of human interferon, alpha or gamma. No obvious signs of toxicity were observed at all rHuTNF doses administered and weights of control and treated mice at the end of the experiments were comparable." @default.
- W2172109321 created "2016-06-24" @default.
- W2172109321 creator A5007707038 @default.
- W2172109321 creator A5007814695 @default.
- W2172109321 creator A5012593382 @default.
- W2172109321 creator A5054994879 @default.
- W2172109321 creator A5060405762 @default.
- W2172109321 creator A5061389369 @default.
- W2172109321 creator A5064439353 @default.
- W2172109321 date "1986-08-01" @default.
- W2172109321 modified "2023-09-23" @default.
- W2172109321 title "Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons." @default.
- W2172109321 cites W1989783048 @default.
- W2172109321 cites W2002806256 @default.
- W2172109321 cites W2024928333 @default.
- W2172109321 cites W2044038126 @default.
- W2172109321 cites W2048325240 @default.
- W2172109321 cites W2063033450 @default.
- W2172109321 cites W2087436694 @default.
- W2172109321 cites W2116996002 @default.
- W2172109321 cites W2140769991 @default.
- W2172109321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2425938" @default.
- W2172109321 hasPublicationYear "1986" @default.
- W2172109321 type Work @default.
- W2172109321 sameAs 2172109321 @default.
- W2172109321 citedByCount "83" @default.
- W2172109321 countsByYear W21721093212012 @default.
- W2172109321 countsByYear W21721093212014 @default.
- W2172109321 countsByYear W21721093212015 @default.
- W2172109321 countsByYear W21721093212016 @default.
- W2172109321 countsByYear W21721093212017 @default.
- W2172109321 countsByYear W21721093212019 @default.
- W2172109321 countsByYear W21721093212022 @default.
- W2172109321 countsByYear W21721093212023 @default.
- W2172109321 crossrefType "journal-article" @default.
- W2172109321 hasAuthorship W2172109321A5007707038 @default.
- W2172109321 hasAuthorship W2172109321A5007814695 @default.
- W2172109321 hasAuthorship W2172109321A5012593382 @default.
- W2172109321 hasAuthorship W2172109321A5054994879 @default.
- W2172109321 hasAuthorship W2172109321A5060405762 @default.
- W2172109321 hasAuthorship W2172109321A5061389369 @default.
- W2172109321 hasAuthorship W2172109321A5064439353 @default.
- W2172109321 hasConcept C104317684 @default.
- W2172109321 hasConcept C126322002 @default.
- W2172109321 hasConcept C142724271 @default.
- W2172109321 hasConcept C17991360 @default.
- W2172109321 hasConcept C185592680 @default.
- W2172109321 hasConcept C203014093 @default.
- W2172109321 hasConcept C2776178377 @default.
- W2172109321 hasConcept C40767141 @default.
- W2172109321 hasConcept C503630168 @default.
- W2172109321 hasConcept C55493867 @default.
- W2172109321 hasConcept C71924100 @default.
- W2172109321 hasConceptScore W2172109321C104317684 @default.
- W2172109321 hasConceptScore W2172109321C126322002 @default.
- W2172109321 hasConceptScore W2172109321C142724271 @default.
- W2172109321 hasConceptScore W2172109321C17991360 @default.
- W2172109321 hasConceptScore W2172109321C185592680 @default.
- W2172109321 hasConceptScore W2172109321C203014093 @default.
- W2172109321 hasConceptScore W2172109321C2776178377 @default.
- W2172109321 hasConceptScore W2172109321C40767141 @default.
- W2172109321 hasConceptScore W2172109321C503630168 @default.
- W2172109321 hasConceptScore W2172109321C55493867 @default.
- W2172109321 hasConceptScore W2172109321C71924100 @default.
- W2172109321 hasIssue "8" @default.
- W2172109321 hasLocation W21721093211 @default.
- W2172109321 hasOpenAccess W2172109321 @default.
- W2172109321 hasPrimaryLocation W21721093211 @default.
- W2172109321 hasRelatedWork W2050275131 @default.
- W2172109321 hasRelatedWork W2069812515 @default.
- W2172109321 hasRelatedWork W2154921150 @default.
- W2172109321 hasRelatedWork W2289975791 @default.
- W2172109321 hasRelatedWork W2314721164 @default.
- W2172109321 hasRelatedWork W2353959421 @default.
- W2172109321 hasRelatedWork W2361827419 @default.
- W2172109321 hasRelatedWork W2412225632 @default.
- W2172109321 hasRelatedWork W2415133252 @default.
- W2172109321 hasRelatedWork W2776042838 @default.
- W2172109321 hasVolume "46" @default.
- W2172109321 isParatext "false" @default.
- W2172109321 isRetracted "false" @default.
- W2172109321 magId "2172109321" @default.
- W2172109321 workType "article" @default.