FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172110273> ?p ?o ?g. }

• W2172110273 endingPage "307" @default.
• W2172110273 startingPage "298" @default.
• W2172110273 abstract "I-BAR proteins are well-known actin-cytoskeleton adaptors and have been observed to be involved in the formation of plasma membrane protrusions (filopodia). I-BAR proteins contain an all-helical, crescent-shaped IRSp53-MIM domain (IMD) dimer that is believed to be able to couple with a membrane shape. This coupling could involve the sensing and even the generation of negative plasma membrane curvature. Indeed, the in vitro studies have shown that IMDs can induce inward tubulation of liposomes. While N-BAR domains, which generate positive membrane curvature, have received a considerable amount of attention from both theory and experiments, the mechanisms of curvature coupling through IMDs are comparatively less studied and understood. Here we used a membrane-shape stability assay developed recently in our lab to quantitatively characterize IMD-induced membrane-shape transitions. We determined a membrane-shape stability diagram for IMDs that reveals how membrane tension and protein density can comodulate the generation of IMD-induced membrane protrusions. From comparison to analytical theory, we determine three key parameters that characterize the curvature coupling of IMD. We find that the curvature generation capacity of IMDs is significantly stronger compared to that of endophilin, an N-BAR protein known to be involved in plasma membrane shape transitions. Contrary to N-BAR domains, where amphipathic helix insertion is known to promote its membrane curvature generation, for IMDs we find that amphipathic helices inhibit membrane shape transitions, consistent with the inverse curvature that IMDs generate. Importantly, in both of these types of BAR domains, electrostatic interactions affect membrane-binding capacity, but do not appear to affect the curvature generation capacity of the protein. These two types of BAR domain proteins show qualitatively similar membrane shape stability diagrams, suggesting an underlying ubiquitous mechanism by which peripheral proteins regulate membrane curvature." @default.
• W2172110273 created "2016-06-24" @default.
• W2172110273 creator A5021861092 @default.
• W2172110273 creator A5033379136 @default.
• W2172110273 creator A5070289551 @default.
• W2172110273 date "2015-07-01" @default.
• W2172110273 modified "2023-10-16" @default.
• W2172110273 title "Regulation of Membrane-Shape Transitions Induced by I-BAR Domains" @default.
• W2172110273 cites W1485384468 @default.
• W2172110273 cites W1966188939 @default.
• W2172110273 cites W1971060242 @default.
• W2172110273 cites W1979324769 @default.
• W2172110273 cites W1982792659 @default.
• W2172110273 cites W1983541992 @default.
• W2172110273 cites W1985242798 @default.
• W2172110273 cites W1987835269 @default.
• W2172110273 cites W2001869735 @default.
• W2172110273 cites W2005047484 @default.
• W2172110273 cites W2005718392 @default.
• W2172110273 cites W2007483105 @default.
• W2172110273 cites W2008063578 @default.
• W2172110273 cites W2008150634 @default.
• W2172110273 cites W2012083125 @default.
• W2172110273 cites W2017998270 @default.
• W2172110273 cites W2019494037 @default.
• W2172110273 cites W2023236182 @default.
• W2172110273 cites W2023863818 @default.
• W2172110273 cites W2023922465 @default.
• W2172110273 cites W2025448275 @default.
• W2172110273 cites W2029681004 @default.
• W2172110273 cites W2031186345 @default.
• W2172110273 cites W2031815624 @default.
• W2172110273 cites W2032783055 @default.
• W2172110273 cites W2038634187 @default.
• W2172110273 cites W2046528357 @default.
• W2172110273 cites W2047146830 @default.
• W2172110273 cites W2048126811 @default.
• W2172110273 cites W2049315117 @default.
• W2172110273 cites W2053591561 @default.
• W2172110273 cites W2054566118 @default.
• W2172110273 cites W2055395908 @default.
• W2172110273 cites W2055409462 @default.
• W2172110273 cites W2057935289 @default.
• W2172110273 cites W2063116040 @default.
• W2172110273 cites W2064585995 @default.
• W2172110273 cites W2065142546 @default.
• W2172110273 cites W2075336591 @default.
• W2172110273 cites W2080484884 @default.
• W2172110273 cites W2081076131 @default.
• W2172110273 cites W2083468237 @default.
• W2172110273 cites W2092040620 @default.
• W2172110273 cites W2093450191 @default.
• W2172110273 cites W2106217679 @default.
• W2172110273 cites W2114464968 @default.
• W2172110273 cites W2117649547 @default.
• W2172110273 cites W2119253842 @default.
• W2172110273 cites W2129063557 @default.
• W2172110273 cites W2131158518 @default.
• W2172110273 cites W2139784023 @default.
• W2172110273 cites W2144047866 @default.
• W2172110273 cites W2152035225 @default.
• W2172110273 cites W2165845794 @default.
• W2172110273 cites W2317534145 @default.
• W2172110273 doi "https://doi.org/10.1016/j.bpj.2015.06.010" @default.
• W2172110273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4621619" @default.
• W2172110273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26200865" @default.
• W2172110273 hasPublicationYear "2015" @default.
• W2172110273 type Work @default.
• W2172110273 sameAs 2172110273 @default.
• W2172110273 citedByCount "33" @default.
• W2172110273 countsByYear W21721102732016 @default.
• W2172110273 countsByYear W21721102732017 @default.
• W2172110273 countsByYear W21721102732018 @default.
• W2172110273 countsByYear W21721102732019 @default.
• W2172110273 countsByYear W21721102732020 @default.
• W2172110273 countsByYear W21721102732021 @default.
• W2172110273 countsByYear W21721102732022 @default.
• W2172110273 countsByYear W21721102732023 @default.
• W2172110273 crossrefType "journal-article" @default.
• W2172110273 hasAuthorship W2172110273A5021861092 @default.
• W2172110273 hasAuthorship W2172110273A5033379136 @default.
• W2172110273 hasAuthorship W2172110273A5070289551 @default.
• W2172110273 hasBestOaLocation W21721102731 @default.
• W2172110273 hasConcept C121332964 @default.
• W2172110273 hasConcept C12554922 @default.
• W2172110273 hasConcept C131584629 @default.
• W2172110273 hasConcept C142669718 @default.
• W2172110273 hasConcept C142874826 @default.
• W2172110273 hasConcept C144647389 @default.
• W2172110273 hasConcept C1491633281 @default.
• W2172110273 hasConcept C153294291 @default.
• W2172110273 hasConcept C161200384 @default.
• W2172110273 hasConcept C185592680 @default.
• W2172110273 hasConcept C188721877 @default.
• W2172110273 hasConcept C18903297 @default.
• W2172110273 hasConcept C191897082 @default.
• W2172110273 hasConcept C192562407 @default.
• W2172110273 hasConcept C195065555 @default.

• next