FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172114433> ?p ?o ?g. }

• W2172114433 endingPage "3107" @default.
• W2172114433 startingPage "3095" @default.
• W2172114433 abstract "The unfolded protein response (UPR) regulates the protein-folding capacity of the endoplasmic reticulum (ER) according to cellular demand. In mammalian cells, three ER transmembrane components, IRE1, PERK, and ATF6, initiate distinct UPR signaling branches. We show that these UPR components display distinct sensitivities toward different forms of ER stress. ER stress induced by ER Ca 2+ release in particular revealed fundamental differences in the properties of UPR signaling branches. Compared with the rapid response of both IRE1 and PERK to ER stress induced by thapsigargin, an ER Ca 2+ ATPase inhibitor, the response of ATF6 was markedly delayed. These studies are the first side-by-side comparisons of UPR signaling branch activation and reveal intrinsic features of UPR stress sensor activation in response to alternate forms of ER stress. As such, they provide initial groundwork toward understanding how ER stress sensors can confer different responses and how optimal UPR responses are achieved in physiological settings." @default.
• W2172114433 created "2016-06-24" @default.
• W2172114433 creator A5004787452 @default.
• W2172114433 creator A5014198852 @default.
• W2172114433 creator A5030069081 @default.
• W2172114433 date "2006-07-01" @default.
• W2172114433 modified "2023-10-14" @default.
• W2172114433 title "Intrinsic Capacities of Molecular Sensors of the Unfolded Protein Response to Sense Alternate Forms of Endoplasmic Reticulum Stress" @default.
• W2172114433 cites W1546139069 @default.
• W2172114433 cites W1965843055 @default.
• W2172114433 cites W1967883750 @default.
• W2172114433 cites W1970090817 @default.
• W2172114433 cites W1980438612 @default.
• W2172114433 cites W1981503496 @default.
• W2172114433 cites W1981551685 @default.
• W2172114433 cites W1983514779 @default.
• W2172114433 cites W1986737010 @default.
• W2172114433 cites W1988482079 @default.
• W2172114433 cites W1990400035 @default.
• W2172114433 cites W1991999080 @default.
• W2172114433 cites W2010494349 @default.
• W2172114433 cites W2010668098 @default.
• W2172114433 cites W2019424220 @default.
• W2172114433 cites W2021632088 @default.
• W2172114433 cites W2025846979 @default.
• W2172114433 cites W2029642537 @default.
• W2172114433 cites W2030574146 @default.
• W2172114433 cites W2038763220 @default.
• W2172114433 cites W2039140102 @default.
• W2172114433 cites W2053535274 @default.
• W2172114433 cites W2059710944 @default.
• W2172114433 cites W2061774676 @default.
• W2172114433 cites W2062918974 @default.
• W2172114433 cites W2062956001 @default.
• W2172114433 cites W2067018477 @default.
• W2172114433 cites W2071273959 @default.
• W2172114433 cites W2078700501 @default.
• W2172114433 cites W2081294646 @default.
• W2172114433 cites W2082765660 @default.
• W2172114433 cites W2089273088 @default.
• W2172114433 cites W2093158584 @default.
• W2172114433 cites W2100472948 @default.
• W2172114433 cites W2104988047 @default.
• W2172114433 cites W2106314483 @default.
• W2172114433 cites W2106983618 @default.
• W2172114433 cites W2107601804 @default.
• W2172114433 cites W2115137627 @default.
• W2172114433 cites W2120736516 @default.
• W2172114433 cites W2127639686 @default.
• W2172114433 cites W2127848114 @default.
• W2172114433 cites W2127906377 @default.
• W2172114433 cites W2131632095 @default.
• W2172114433 cites W2138009056 @default.
• W2172114433 cites W2144065739 @default.
• W2172114433 cites W2147646344 @default.
• W2172114433 cites W2151608616 @default.
• W2172114433 cites W2155884826 @default.
• W2172114433 cites W2157377535 @default.
• W2172114433 cites W2162076197 @default.
• W2172114433 cites W2163285372 @default.
• W2172114433 cites W2170939329 @default.
• W2172114433 cites W2192080449 @default.
• W2172114433 cites W4245041543 @default.
• W2172114433 doi "https://doi.org/10.1091/mbc.e06-01-0055" @default.
• W2172114433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1483043" @default.
• W2172114433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16672378" @default.
• W2172114433 hasPublicationYear "2006" @default.
• W2172114433 type Work @default.
• W2172114433 sameAs 2172114433 @default.
• W2172114433 citedByCount "186" @default.
• W2172114433 countsByYear W21721144332012 @default.
• W2172114433 countsByYear W21721144332013 @default.
• W2172114433 countsByYear W21721144332014 @default.
• W2172114433 countsByYear W21721144332015 @default.
• W2172114433 countsByYear W21721144332016 @default.
• W2172114433 countsByYear W21721144332017 @default.
• W2172114433 countsByYear W21721144332018 @default.
• W2172114433 countsByYear W21721144332019 @default.
• W2172114433 countsByYear W21721144332020 @default.
• W2172114433 countsByYear W21721144332021 @default.
• W2172114433 countsByYear W21721144332022 @default.
• W2172114433 countsByYear W21721144332023 @default.
• W2172114433 crossrefType "journal-article" @default.
• W2172114433 hasAuthorship W2172114433A5004787452 @default.
• W2172114433 hasAuthorship W2172114433A5014198852 @default.
• W2172114433 hasAuthorship W2172114433A5030069081 @default.
• W2172114433 hasBestOaLocation W21721144332 @default.
• W2172114433 hasConcept C139447449 @default.
• W2172114433 hasConcept C158617107 @default.
• W2172114433 hasConcept C170493617 @default.
• W2172114433 hasConcept C24530287 @default.
• W2172114433 hasConcept C2777146706 @default.
• W2172114433 hasConcept C2777575526 @default.
• W2172114433 hasConcept C2778997996 @default.
• W2172114433 hasConcept C55493867 @default.
• W2172114433 hasConcept C62478195 @default.
• W2172114433 hasConcept C86803240 @default.
• W2172114433 hasConcept C95444343 @default.

• next