FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172116844> ?p ?o ?g. }

• W2172116844 endingPage "296" @default.
• W2172116844 startingPage "296" @default.
• W2172116844 abstract "We previously reported that, in human heat shock protein (Hsp) 90 (hHsp90), there are 4 highly immunogenic sites, designated sites Ia, Ib, Ic, and II. This study was performed to further characterize their epitopes and to identify the epitope that is potentially common to all members of the Hsp90 family. Panning of a bacterial library carrying randomized dodecapeptides revealed that Glu251-Ser-X-Asp254 constituted site Ia and Pro295-Ile-Trp-Thr-Arg299, site Ic. Site II (Asp701-Pro717) was composed of several epitopes. When 19 anti-hHsp90 monoclonal antibodies (mAbs) were subjected to immunoblotting against recombinant forms of 7 Hsp90-family members, 2 mAbs (K41110 and K41116C) that recognized site Ic bound to yeast Hsp90 with affinity identical to that for hHsp90, and 1 mAb (K3729) that recognized Glu222-Ala23, of hHsp90beta could bind to human 94-kDa glucose-regulated protein (Grp94), an endoplasmic reticulum paralog of Hsp90. Among the 5 amino acids constituting site Ic, Trp297 and Pro295 were essential for recognition by all anti-site-Ic mAbs, and Arg299 was important for most of them. The necessity of Ile296, Thr298, and Arg299, which are replaced by Leu, Met/Leu, and Lys, respectively, in some eukaryotic Hsp90, was dependent on the mAbs, and K41110 and K41116C could react with Hsp90s carrying these substitutions. From these data taken together, we propose that the pentapeptide Pro295-Ile-Trp-Thr-Arg299 of hHsp90 functions as an immunodominant epitope common to all eukaryotic Hsp90." @default.
• W2172116844 created "2016-06-24" @default.
• W2172116844 creator A5028258913 @default.
• W2172116844 creator A5054967720 @default.
• W2172116844 creator A5059473531 @default.
• W2172116844 creator A5060865292 @default.
• W2172116844 date "2005-01-01" @default.
• W2172116844 modified "2023-09-24" @default.
• W2172116844 title "Identification of the pentapeptide constituting a dominant epitope common to all eukaryotic heat shock protein 90 molecular chaperones" @default.
• W2172116844 cites W1479809193 @default.
• W2172116844 cites W1509643601 @default.
• W2172116844 cites W1521753997 @default.
• W2172116844 cites W1524512823 @default.
• W2172116844 cites W1529513756 @default.
• W2172116844 cites W1604134423 @default.
• W2172116844 cites W165780426 @default.
• W2172116844 cites W1821289342 @default.
• W2172116844 cites W1852860123 @default.
• W2172116844 cites W1872290593 @default.
• W2172116844 cites W1876735995 @default.
• W2172116844 cites W1924282271 @default.
• W2172116844 cites W1930313341 @default.
• W2172116844 cites W1956379070 @default.
• W2172116844 cites W1968007975 @default.
• W2172116844 cites W1975354656 @default.
• W2172116844 cites W1982950140 @default.
• W2172116844 cites W1983665072 @default.
• W2172116844 cites W1984831405 @default.
• W2172116844 cites W1987015641 @default.
• W2172116844 cites W1991158062 @default.
• W2172116844 cites W1996172825 @default.
• W2172116844 cites W1999013133 @default.
• W2172116844 cites W1999352564 @default.
• W2172116844 cites W2012907133 @default.
• W2172116844 cites W2017919042 @default.
• W2172116844 cites W2033226172 @default.
• W2172116844 cites W2033639177 @default.
• W2172116844 cites W2046044279 @default.
• W2172116844 cites W2051262391 @default.
• W2172116844 cites W2052779551 @default.
• W2172116844 cites W2052876219 @default.
• W2172116844 cites W2055533988 @default.
• W2172116844 cites W2057415866 @default.
• W2172116844 cites W2059364992 @default.
• W2172116844 cites W2061394503 @default.
• W2172116844 cites W2071221844 @default.
• W2172116844 cites W2072731681 @default.
• W2172116844 cites W2074579328 @default.
• W2172116844 cites W2075155315 @default.
• W2172116844 cites W2076945013 @default.
• W2172116844 cites W2079375960 @default.
• W2172116844 cites W2081946878 @default.
• W2172116844 cites W2084159890 @default.
• W2172116844 cites W2084332037 @default.
• W2172116844 cites W2084457970 @default.
• W2172116844 cites W2084766051 @default.
• W2172116844 cites W2085800283 @default.
• W2172116844 cites W2092688929 @default.
• W2172116844 cites W2103214568 @default.
• W2172116844 cites W2104011738 @default.
• W2172116844 cites W2108255072 @default.
• W2172116844 cites W2110066345 @default.
• W2172116844 cites W2112133866 @default.
• W2172116844 cites W2122896696 @default.
• W2172116844 cites W2136689951 @default.
• W2172116844 cites W2139306838 @default.
• W2172116844 cites W2148401329 @default.
• W2172116844 cites W2158579143 @default.
• W2172116844 cites W2164091676 @default.
• W2172116844 doi "https://doi.org/10.1379/csc-129r.1" @default.
• W2172116844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1283875" @default.
• W2172116844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16333984" @default.
• W2172116844 hasPublicationYear "2005" @default.
• W2172116844 type Work @default.
• W2172116844 sameAs 2172116844 @default.
• W2172116844 citedByCount "9" @default.
• W2172116844 countsByYear W21721168442012 @default.
• W2172116844 countsByYear W21721168442017 @default.
• W2172116844 countsByYear W21721168442018 @default.
• W2172116844 countsByYear W21721168442021 @default.
• W2172116844 crossrefType "journal-article" @default.
• W2172116844 hasAuthorship W2172116844A5028258913 @default.
• W2172116844 hasAuthorship W2172116844A5054967720 @default.
• W2172116844 hasAuthorship W2172116844A5059473531 @default.
• W2172116844 hasAuthorship W2172116844A5060865292 @default.
• W2172116844 hasBestOaLocation W21721168442 @default.
• W2172116844 hasConcept C104317684 @default.
• W2172116844 hasConcept C107824862 @default.
• W2172116844 hasConcept C153911025 @default.
• W2172116844 hasConcept C158617107 @default.
• W2172116844 hasConcept C159654299 @default.
• W2172116844 hasConcept C195616568 @default.
• W2172116844 hasConcept C205260736 @default.
• W2172116844 hasConcept C2775932338 @default.
• W2172116844 hasConcept C2777576037 @default.
• W2172116844 hasConcept C2779222958 @default.
• W2172116844 hasConcept C2779281246 @default.
• W2172116844 hasConcept C2780868878 @default.

• next