Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172133607> ?p ?o ?g. }
- W2172133607 endingPage "29" @default.
- W2172133607 startingPage "17" @default.
- W2172133607 abstract "The present study was designed to evaluate whether CP was beneficial in alleviating myocardial fibrosis following I/R injury.Sprague-Dawley rats were subjected to 30 minutes occlusion of the LADCA, followed by reperfusion. CP (0.4 or 0.8 g/kg) was daily administered starting from three hour after reperfusion until day 6. Coronary venular diameter, RBC velocity, albumin leakage, MBF, heart function, myocardial infarction and fibrosis size, myocardium ultrastructure, MPO activity, and MDA level were evaluated. The expression of MCP-1, RP S19, TGF-β1, P-Smad3, Smad4, MMP-9 and α-SMA, and the infiltration of leukocytes were examined.CP post-treatment ameliorated I/R-induced myocardial RBC velocity reduction, MBF decrease, cardiac dysfunction, and albumin leakage increase. Moreover, myocardial infarction and fibrosis size, MPO activity, MDA level, the expression of RP S19, TGF-β1, P-Smad3, Smad4, MMP-9 and α-SMA, the number of CD68-positive cells increased significantly after I/R, and myocardium collagen deposition was observed on day 6 after reperfusion. All the alterations after I/R were significantly ameliorated by CP.Post-treatment with CP ameliorates I/R-induced myocardial fibrosis, suggesting that CP may be applied as an option for preventing cardiac remodeling after I/R injury." @default.
- W2172133607 created "2016-06-24" @default.
- W2172133607 creator A5000095164 @default.
- W2172133607 creator A5006378344 @default.
- W2172133607 creator A5012307033 @default.
- W2172133607 creator A5014609476 @default.
- W2172133607 creator A5029438350 @default.
- W2172133607 creator A5033415932 @default.
- W2172133607 creator A5038547888 @default.
- W2172133607 creator A5040897632 @default.
- W2172133607 creator A5042115463 @default.
- W2172133607 creator A5049801163 @default.
- W2172133607 creator A5063161253 @default.
- W2172133607 creator A5069984943 @default.
- W2172133607 creator A5072623207 @default.
- W2172133607 creator A5080166441 @default.
- W2172133607 creator A5086949810 @default.
- W2172133607 date "2013-01-01" @default.
- W2172133607 modified "2023-10-02" @default.
- W2172133607 title "Treatment with Cardiotonic Pills<sup>®</sup>after Ischemia-Reperfusion Ameliorates Myocardial Fibrosis in Rats" @default.
- W2172133607 cites W1976863476 @default.
- W2172133607 cites W1987767880 @default.
- W2172133607 cites W1988408998 @default.
- W2172133607 cites W2011813460 @default.
- W2172133607 cites W2016513751 @default.
- W2172133607 cites W2028652081 @default.
- W2172133607 cites W2032901102 @default.
- W2172133607 cites W2036198000 @default.
- W2172133607 cites W2038824249 @default.
- W2172133607 cites W2043425865 @default.
- W2172133607 cites W2049801272 @default.
- W2172133607 cites W2075282446 @default.
- W2172133607 cites W2080334303 @default.
- W2172133607 cites W2084407248 @default.
- W2172133607 cites W2088532961 @default.
- W2172133607 cites W2091902453 @default.
- W2172133607 cites W2092869368 @default.
- W2172133607 cites W2102085357 @default.
- W2172133607 cites W2103868782 @default.
- W2172133607 cites W2103943934 @default.
- W2172133607 cites W2105830536 @default.
- W2172133607 cites W2107359871 @default.
- W2172133607 cites W2110657739 @default.
- W2172133607 cites W2131305115 @default.
- W2172133607 cites W2144479375 @default.
- W2172133607 cites W2147758809 @default.
- W2172133607 cites W2150428021 @default.
- W2172133607 cites W2155450712 @default.
- W2172133607 cites W2160414137 @default.
- W2172133607 cites W2167931885 @default.
- W2172133607 cites W2168890097 @default.
- W2172133607 cites W2171953734 @default.
- W2172133607 cites W2316988307 @default.
- W2172133607 cites W4243734796 @default.
- W2172133607 doi "https://doi.org/10.1111/micc.12002" @default.
- W2172133607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22913380" @default.
- W2172133607 hasPublicationYear "2013" @default.
- W2172133607 type Work @default.
- W2172133607 sameAs 2172133607 @default.
- W2172133607 citedByCount "30" @default.
- W2172133607 countsByYear W21721336072013 @default.
- W2172133607 countsByYear W21721336072014 @default.
- W2172133607 countsByYear W21721336072015 @default.
- W2172133607 countsByYear W21721336072016 @default.
- W2172133607 countsByYear W21721336072017 @default.
- W2172133607 countsByYear W21721336072018 @default.
- W2172133607 countsByYear W21721336072019 @default.
- W2172133607 countsByYear W21721336072020 @default.
- W2172133607 countsByYear W21721336072021 @default.
- W2172133607 countsByYear W21721336072022 @default.
- W2172133607 crossrefType "journal-article" @default.
- W2172133607 hasAuthorship W2172133607A5000095164 @default.
- W2172133607 hasAuthorship W2172133607A5006378344 @default.
- W2172133607 hasAuthorship W2172133607A5012307033 @default.
- W2172133607 hasAuthorship W2172133607A5014609476 @default.
- W2172133607 hasAuthorship W2172133607A5029438350 @default.
- W2172133607 hasAuthorship W2172133607A5033415932 @default.
- W2172133607 hasAuthorship W2172133607A5038547888 @default.
- W2172133607 hasAuthorship W2172133607A5040897632 @default.
- W2172133607 hasAuthorship W2172133607A5042115463 @default.
- W2172133607 hasAuthorship W2172133607A5049801163 @default.
- W2172133607 hasAuthorship W2172133607A5063161253 @default.
- W2172133607 hasAuthorship W2172133607A5069984943 @default.
- W2172133607 hasAuthorship W2172133607A5072623207 @default.
- W2172133607 hasAuthorship W2172133607A5080166441 @default.
- W2172133607 hasAuthorship W2172133607A5086949810 @default.
- W2172133607 hasConcept C111566952 @default.
- W2172133607 hasConcept C126322002 @default.
- W2172133607 hasConcept C164705383 @default.
- W2172133607 hasConcept C2776125364 @default.
- W2172133607 hasConcept C2777798775 @default.
- W2172133607 hasConcept C2778198053 @default.
- W2172133607 hasConcept C2780114680 @default.
- W2172133607 hasConcept C2780393670 @default.
- W2172133607 hasConcept C2780559512 @default.
- W2172133607 hasConcept C3018763269 @default.
- W2172133607 hasConcept C500558357 @default.
- W2172133607 hasConcept C541997718 @default.