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• W2172183744 abstract "Current approaches to skin equivalents often only include the epidermis and dermis. Here, a full-thickness skin equivalent is described including epidermis, dermis, and hypodermis, that could serve as an in vitro model for studying skin biology or as a platform for consumer product testing. The construct is easy to handle and is maintained for >14 d while expressing physiological morphologies of the epidermis and dermis, seen by keratin 10, collagens I and IV expression. The skin equivalent produces glycerol and leptin, markers of adipose metabolism. This work serves as a foundation for understanding a few necessary factors needed to develop a stable, functional model of full-thickness skin." @default.
• W2172183744 created "2016-06-24" @default.
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• W2172183744 date "2012-11-19" @default.
• W2172183744 modified "2023-09-29" @default.
• W2172183744 title "In vitro 3D Full-Thickness Skin-Equivalent Tissue Model Using Silk and Collagen Biomaterials" @default.
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• W2172183744 doi "https://doi.org/10.1002/mabi.201200262" @default.
• W2172183744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3724336" @default.
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