FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172185872> ?p ?o ?g. }

• W2172185872 endingPage "29" @default.
• W2172185872 startingPage "21" @default.
• W2172185872 abstract "Adipose tissue contains macrophages whose state of activation is regulated as obesity develops. Macrophage-secreted factors influence critical processes involved in adipose tissue homeostasis, including preadipocyte proliferation and differentiation into adipocytes. Macrophage-conditioned medium (MacCM) from J774A.1 macrophages protects 3T3-L1 preadipocytes from apoptosis through platelet-derived growth factor (PDGF) signaling. Here, we investigated the effect of macrophage activation on MacCM-dependent preadipocyte survival. MacCM was prepared following activation of either J774A.1 macrophages with lipopolysaccharide (LPS) or human primary monocyte-derived macrophages (MD-macrophages) with LPS or interleukin 4 (IL4). 3T3-L1 and human primary preadipocytes were induced to undergo apoptosis in MacCM, and apoptosis was quantified by cell enumeration or Hoechst nuclear staining. Preadipocyte PDGF signaling was assessed by immunoblot analysis of phosphorylated PDGF receptor, Akt, and ERK1/2. Pro-inflammatory activation of J774A.1 macrophages with LPS inhibited the pro-survival activity of MacCM on 3T3-L1 preadipocytes, despite intact PDGF signaling. Upregulation of macrophage tumor necrosis factor a (TNFα) expression occurred in response to LPS, and TNFα was demonstrated to be responsible for the inability of LPS-J774A.1-MacCM to inhibit preadipocyte apoptosis. Furthermore, MacCM from human MD-macrophages (MD-MacCM) inhibited apoptosis of primary human preadipocytes. MD-MacCM from LPS-treated macrophages, but not IL4-treated anti-inflammatory macrophages, was unable to protect human preadipocytes from cell death. In both murine cell lines and human primary cells, pro-inflammatory activation of macrophages inhibits their pro-survival activity, favoring preadipocyte death. These findings may be relevant to preadipocyte fate and adipose tissue remodeling in obesity." @default.
• W2172185872 created "2016-06-24" @default.
• W2172185872 creator A5067908458 @default.
• W2172185872 creator A5080610661 @default.
• W2172185872 creator A5084271543 @default.
• W2172185872 creator A5088312161 @default.
• W2172185872 date "2012-05-03" @default.
• W2172185872 modified "2023-09-25" @default.
• W2172185872 title "The activation state of macrophages alters their ability to suppress preadipocyte apoptosis" @default.
• W2172185872 cites W1578531215 @default.
• W2172185872 cites W1923917571 @default.
• W2172185872 cites W1972140692 @default.
• W2172185872 cites W1972348350 @default.
• W2172185872 cites W1977795315 @default.
• W2172185872 cites W1988926458 @default.
• W2172185872 cites W2011255130 @default.
• W2172185872 cites W2012650972 @default.
• W2172185872 cites W2014171165 @default.
• W2172185872 cites W2028441056 @default.
• W2172185872 cites W2051215268 @default.
• W2172185872 cites W2059258210 @default.
• W2172185872 cites W2063634334 @default.
• W2172185872 cites W2065210647 @default.
• W2172185872 cites W2069935661 @default.
• W2172185872 cites W2077319368 @default.
• W2172185872 cites W2084974537 @default.
• W2172185872 cites W2091371988 @default.
• W2172185872 cites W2098386233 @default.
• W2172185872 cites W2100837269 @default.
• W2172185872 cites W2110330424 @default.
• W2172185872 cites W2112940161 @default.
• W2172185872 cites W2121845219 @default.
• W2172185872 cites W2122506498 @default.
• W2172185872 cites W2136428723 @default.
• W2172185872 cites W2145690342 @default.
• W2172185872 cites W2145697808 @default.
• W2172185872 cites W2158171063 @default.
• W2172185872 cites W2159346623 @default.
• W2172185872 cites W2164282978 @default.
• W2172185872 cites W2167485774 @default.
• W2172185872 cites W2168747539 @default.
• W2172185872 cites W2170499033 @default.
• W2172185872 cites W4231655725 @default.
• W2172185872 cites W4238497443 @default.
• W2172185872 cites W4249727000 @default.
• W2172185872 doi "https://doi.org/10.1530/joe-12-0114" @default.
• W2172185872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22556272" @default.
• W2172185872 hasPublicationYear "2012" @default.
• W2172185872 type Work @default.
• W2172185872 sameAs 2172185872 @default.
• W2172185872 citedByCount "13" @default.
• W2172185872 countsByYear W21721858722013 @default.
• W2172185872 countsByYear W21721858722014 @default.
• W2172185872 countsByYear W21721858722016 @default.
• W2172185872 countsByYear W21721858722017 @default.
• W2172185872 countsByYear W21721858722019 @default.
• W2172185872 countsByYear W21721858722021 @default.
• W2172185872 countsByYear W21721858722022 @default.
• W2172185872 countsByYear W21721858722023 @default.
• W2172185872 crossrefType "journal-article" @default.
• W2172185872 hasAuthorship W2172185872A5067908458 @default.
• W2172185872 hasAuthorship W2172185872A5080610661 @default.
• W2172185872 hasAuthorship W2172185872A5084271543 @default.
• W2172185872 hasAuthorship W2172185872A5088312161 @default.
• W2172185872 hasBestOaLocation W21721858721 @default.
• W2172185872 hasConcept C126322002 @default.
• W2172185872 hasConcept C134018914 @default.
• W2172185872 hasConcept C142536801 @default.
• W2172185872 hasConcept C151955695 @default.
• W2172185872 hasConcept C171089720 @default.
• W2172185872 hasConcept C17675752 @default.
• W2172185872 hasConcept C17991360 @default.
• W2172185872 hasConcept C185592680 @default.
• W2172185872 hasConcept C190283241 @default.
• W2172185872 hasConcept C202751555 @default.
• W2172185872 hasConcept C203014093 @default.
• W2172185872 hasConcept C2776175234 @default.
• W2172185872 hasConcept C2778754761 @default.
• W2172185872 hasConcept C2779244956 @default.
• W2172185872 hasConcept C2781184567 @default.
• W2172185872 hasConcept C55493867 @default.
• W2172185872 hasConcept C71924100 @default.
• W2172185872 hasConcept C86803240 @default.
• W2172185872 hasConcept C95444343 @default.
• W2172185872 hasConceptScore W2172185872C126322002 @default.
• W2172185872 hasConceptScore W2172185872C134018914 @default.
• W2172185872 hasConceptScore W2172185872C142536801 @default.
• W2172185872 hasConceptScore W2172185872C151955695 @default.
• W2172185872 hasConceptScore W2172185872C171089720 @default.
• W2172185872 hasConceptScore W2172185872C17675752 @default.
• W2172185872 hasConceptScore W2172185872C17991360 @default.
• W2172185872 hasConceptScore W2172185872C185592680 @default.
• W2172185872 hasConceptScore W2172185872C190283241 @default.
• W2172185872 hasConceptScore W2172185872C202751555 @default.
• W2172185872 hasConceptScore W2172185872C203014093 @default.
• W2172185872 hasConceptScore W2172185872C2776175234 @default.
• W2172185872 hasConceptScore W2172185872C2778754761 @default.
• W2172185872 hasConceptScore W2172185872C2779244956 @default.

• next