FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172190121> ?p ?o ?g. }

• W2172190121 endingPage "179" @default.
• W2172190121 startingPage "171" @default.
• W2172190121 abstract "Objective The molecular mechanisms underlying stress urinary incontinence (SUI) are not clear. In light of the limited availability of human tissue for study, we explored the changes in the urethra of C57BL/6 mice with experimentally induced SUI. Study design Twelve virgin female mice were randomized into two groups: one group undergoing vaginal distension (VD) for 1 h with an 8-mm dilator, and a non-instrumented control group. Four days after VD, leak point pressures (LPP) and maximum urethral closure pressure (MUCP) were assessed in these mice under urethane (1 g/kg, i.p.) anesthesia. After measuring LPP and MUCP, the animals were sacrificed, and the urethras were removed for proteomic analysis using 2-dimensional differential gel electrophoresis (2D DIGE) and liquid chromatography–tandem mass spectrometry (LC–MS/MS) technology. Lastly, interaction between these proteins was further analyzed using MetaCore. Results LPP and MUCP values were significantly decreased in the 8-mm VD groups compared with the non-instrumented control group. Sixty-eight differentially expressed proteins of urethra from female mice with and without VD were identified. Of these, 19 proteins were up-regulated and 49 were down-regulated. The majority of the VD-induced proteins were involved in generation of precursor metabolites and energy, oxidation of reduction, regulation of apoptosis, and glycolysis. Myosin expression in the urethra was significantly decreased in the 8-mm VD group as compared with the control group. Conclusions As a model of simulated birth trauma, VD can induce SUI in female mice. Under-expression of myosin plays a plausible role in the pathogenesis of SUI following vaginal trauma." @default.
• W2172190121 created "2016-06-24" @default.
• W2172190121 creator A5008211285 @default.
• W2172190121 creator A5023444875 @default.
• W2172190121 creator A5024251430 @default.
• W2172190121 creator A5047262363 @default.
• W2172190121 creator A5069420998 @default.
• W2172190121 creator A5083510599 @default.
• W2172190121 date "2013-11-01" @default.
• W2172190121 modified "2023-09-23" @default.
• W2172190121 title "Proteomic analysis related to stress urinary incontinence following vaginal trauma in female mice" @default.
• W2172190121 cites W1604629913 @default.
• W2172190121 cites W1976180069 @default.
• W2172190121 cites W1980242273 @default.
• W2172190121 cites W1998562766 @default.
• W2172190121 cites W2016630348 @default.
• W2172190121 cites W2022518740 @default.
• W2172190121 cites W2029389307 @default.
• W2172190121 cites W2033649816 @default.
• W2172190121 cites W2034224375 @default.
• W2172190121 cites W2036952849 @default.
• W2172190121 cites W2055279988 @default.
• W2172190121 cites W2061653116 @default.
• W2172190121 cites W2066640119 @default.
• W2172190121 cites W2070665737 @default.
• W2172190121 cites W2078970865 @default.
• W2172190121 cites W2093917662 @default.
• W2172190121 cites W2102087112 @default.
• W2172190121 cites W2108716128 @default.
• W2172190121 cites W2149043555 @default.
• W2172190121 cites W2360337399 @default.
• W2172190121 cites W4377205717 @default.
• W2172190121 cites W6733712 @default.
• W2172190121 doi "https://doi.org/10.1016/j.ejogrb.2013.08.034" @default.
• W2172190121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24054828" @default.
• W2172190121 hasPublicationYear "2013" @default.
• W2172190121 type Work @default.
• W2172190121 sameAs 2172190121 @default.
• W2172190121 citedByCount "18" @default.
• W2172190121 countsByYear W21721901212014 @default.
• W2172190121 countsByYear W21721901212015 @default.
• W2172190121 countsByYear W21721901212017 @default.
• W2172190121 countsByYear W21721901212018 @default.
• W2172190121 countsByYear W21721901212019 @default.
• W2172190121 countsByYear W21721901212020 @default.
• W2172190121 countsByYear W21721901212022 @default.
• W2172190121 crossrefType "journal-article" @default.
• W2172190121 hasAuthorship W2172190121A5008211285 @default.
• W2172190121 hasAuthorship W2172190121A5023444875 @default.
• W2172190121 hasAuthorship W2172190121A5024251430 @default.
• W2172190121 hasAuthorship W2172190121A5047262363 @default.
• W2172190121 hasAuthorship W2172190121A5069420998 @default.
• W2172190121 hasAuthorship W2172190121A5083510599 @default.
• W2172190121 hasConcept C126322002 @default.
• W2172190121 hasConcept C126894567 @default.
• W2172190121 hasConcept C134018914 @default.
• W2172190121 hasConcept C141071460 @default.
• W2172190121 hasConcept C16685009 @default.
• W2172190121 hasConcept C190283241 @default.
• W2172190121 hasConcept C2777032099 @default.
• W2172190121 hasConcept C2777085111 @default.
• W2172190121 hasConcept C2777744392 @default.
• W2172190121 hasConcept C2778531004 @default.
• W2172190121 hasConcept C55493867 @default.
• W2172190121 hasConcept C6997183 @default.
• W2172190121 hasConcept C71924100 @default.
• W2172190121 hasConcept C86803240 @default.
• W2172190121 hasConceptScore W2172190121C126322002 @default.
• W2172190121 hasConceptScore W2172190121C126894567 @default.
• W2172190121 hasConceptScore W2172190121C134018914 @default.
• W2172190121 hasConceptScore W2172190121C141071460 @default.
• W2172190121 hasConceptScore W2172190121C16685009 @default.
• W2172190121 hasConceptScore W2172190121C190283241 @default.
• W2172190121 hasConceptScore W2172190121C2777032099 @default.
• W2172190121 hasConceptScore W2172190121C2777085111 @default.
• W2172190121 hasConceptScore W2172190121C2777744392 @default.
• W2172190121 hasConceptScore W2172190121C2778531004 @default.
• W2172190121 hasConceptScore W2172190121C55493867 @default.
• W2172190121 hasConceptScore W2172190121C6997183 @default.
• W2172190121 hasConceptScore W2172190121C71924100 @default.
• W2172190121 hasConceptScore W2172190121C86803240 @default.
• W2172190121 hasIssue "1" @default.
• W2172190121 hasLocation W21721901211 @default.
• W2172190121 hasLocation W21721901212 @default.
• W2172190121 hasOpenAccess W2172190121 @default.
• W2172190121 hasPrimaryLocation W21721901211 @default.
• W2172190121 hasRelatedWork W175436197 @default.
• W2172190121 hasRelatedWork W2029134446 @default.
• W2172190121 hasRelatedWork W2149479949 @default.
• W2172190121 hasRelatedWork W2155690828 @default.
• W2172190121 hasRelatedWork W2169233250 @default.
• W2172190121 hasRelatedWork W2363613785 @default.
• W2172190121 hasRelatedWork W2371700774 @default.
• W2172190121 hasRelatedWork W2392064866 @default.
• W2172190121 hasRelatedWork W2411790315 @default.
• W2172190121 hasRelatedWork W2465168192 @default.
• W2172190121 hasVolume "171" @default.
• W2172190121 isParatext "false" @default.

• next