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• W2172212187 endingPage "2033" @default.
• W2172212187 startingPage "2029" @default.
• W2172212187 abstract "We propose that a nucleotide template-based mechanism facilitates the acquisition of the K65R mutation in subtype C human immunodeficiency virus type 1 (HIV-1). Different patterns of DNA synthesis were observed using DNA templates from viruses of subtype B or C origin. When subtype C reverse transcriptase (RT) was employed to synthesize DNA from subtype C DNA templates, preferential pausing was seen at the nucleotide position responsible for the AAG-to-AGG K65R mutation. This did not occur when the subtype B RT and template were used. Template factors can therefore increase the probability of K65R development in subtype C HIV-1." @default.
• W2172212187 created "2016-06-24" @default.
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• W2172212187 date "2009-02-15" @default.
• W2172212187 modified "2023-10-18" @default.
• W2172212187 title "Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1" @default.
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• W2172212187 doi "https://doi.org/10.1128/jvi.01349-08" @default.
• W2172212187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2643749" @default.
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