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• W2172238512 endingPage "474" @default.
• W2172238512 startingPage "471" @default.
• W2172238512 abstract "gyrA and parC mutations have been identified inn Streptococcus pneumoniae mutants stepwise selected for resistance to sparfloxacin, an antipneumococcal fluoroquinolone. GyrA mutations (at the position equivalent to resistance hot spot Ser-83 in Escherichia coli GyrA) were found in all 17 first-step mutants examined and preceded DNA topoisomerase IV parC mutations (at Ser-79 or Glu-83), which appeared only in second-step mutants. The targeting of gyrase by sparfloxacin in S. pneumoniae but of topoisomerase IV by ciprofloxacin indicates that target preference can be altered by changes in quinolone structure." @default.
• W2172238512 created "2016-06-24" @default.
• W2172238512 creator A5023764364 @default.
• W2172238512 creator A5037473411 @default.
• W2172238512 date "1997-02-01" @default.
• W2172238512 modified "2023-09-27" @default.
• W2172238512 title "Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones" @default.
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• W2172238512 doi "https://doi.org/10.1128/aac.41.2.471" @default.
• W2172238512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/163733" @default.
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