Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172247201> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2172247201 endingPage "376" @default.
- W2172247201 startingPage "369" @default.
- W2172247201 abstract "Current immunosuppressive therapies are very effective in preventing acute rejection (AR) and graft loss following renal transplantation. Newer agents now make it possible to develop equally efficacious but better tolerated and less toxic strategies. This is especially relevant for our ageing recipients. We now compare the efficacy of basiliximab combined with early low-dose cyclosporin therapy to standard OKT3 induction therapy.In this single-centre study, 100 consecutive recipients of cadaveric kidney transplants from November 1998 to August 2000 were treated with basiliximab combined with early low-dose cyclosporin, reduced steroids and mycophenolate mofetil (MMF). Clinical outcomes at 100 d and 1 yr were compared with a group of 26 patients transplanted from March 1995 to November 1998 who received OKT3, delayed full-dose cyclosporin, high-dose steroids and MMF. Amongst basiliximab treated patients, we compared clinical outcomes in those older and younger than 60 yr.Both groups were similar except for a shorter cold ischaemic time in the basiliximab group. Length of stay, number of readmissions, total hospitalization days and cytomegalovirus infections were lower in the basiliximab group. Despite a 40% reduction in steroids, basiliximab-treated patients had fewer biopsy-proven episodes of AR (basiliximab 14% vs. OKT3 35%) and required less antilymphocyte antibody therapy. Clinical outcomes including patient and graft survival were no different between groups. Long-term graft survival for patients over 60 yr was limited primarily by mortality.Compared with OKT3 induction therapy, the combination of early low-dose cyclosporin and basiliximab is steroid sparing, effective, well tolerated and relatively safe." @default.
- W2172247201 created "2016-06-24" @default.
- W2172247201 creator A5004944823 @default.
- W2172247201 creator A5007090759 @default.
- W2172247201 creator A5008549174 @default.
- W2172247201 creator A5013315853 @default.
- W2172247201 creator A5044018603 @default.
- W2172247201 creator A5064549196 @default.
- W2172247201 creator A5065388448 @default.
- W2172247201 creator A5069204893 @default.
- W2172247201 creator A5070823868 @default.
- W2172247201 creator A5086098906 @default.
- W2172247201 date "2003-07-18" @default.
- W2172247201 modified "2023-10-15" @default.
- W2172247201 title "Basiliximab plus low-dose cyclosporin vs. OKT3 for induction immunosuppression following renal transplantation" @default.
- W2172247201 cites W1939259427 @default.
- W2172247201 cites W1973552854 @default.
- W2172247201 cites W1985137297 @default.
- W2172247201 cites W1995791071 @default.
- W2172247201 cites W2023095312 @default.
- W2172247201 cites W2024488440 @default.
- W2172247201 cites W2027400673 @default.
- W2172247201 cites W2034818671 @default.
- W2172247201 cites W2043654400 @default.
- W2172247201 cites W2047179014 @default.
- W2172247201 cites W2061942803 @default.
- W2172247201 cites W2063208585 @default.
- W2172247201 cites W2089268585 @default.
- W2172247201 cites W2089453413 @default.
- W2172247201 cites W2090639386 @default.
- W2172247201 cites W2100001728 @default.
- W2172247201 cites W2112333205 @default.
- W2172247201 cites W2123720448 @default.
- W2172247201 cites W2341259055 @default.
- W2172247201 cites W4252727071 @default.
- W2172247201 doi "https://doi.org/10.1034/j.1399-0012.2003.00061.x" @default.
- W2172247201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12868995" @default.
- W2172247201 hasPublicationYear "2003" @default.
- W2172247201 type Work @default.
- W2172247201 sameAs 2172247201 @default.
- W2172247201 citedByCount "18" @default.
- W2172247201 countsByYear W21722472012013 @default.
- W2172247201 countsByYear W21722472012016 @default.
- W2172247201 countsByYear W21722472012017 @default.
- W2172247201 crossrefType "journal-article" @default.
- W2172247201 hasAuthorship W2172247201A5004944823 @default.
- W2172247201 hasAuthorship W2172247201A5007090759 @default.
- W2172247201 hasAuthorship W2172247201A5008549174 @default.
- W2172247201 hasAuthorship W2172247201A5013315853 @default.
- W2172247201 hasAuthorship W2172247201A5044018603 @default.
- W2172247201 hasAuthorship W2172247201A5064549196 @default.
- W2172247201 hasAuthorship W2172247201A5065388448 @default.
- W2172247201 hasAuthorship W2172247201A5069204893 @default.
- W2172247201 hasAuthorship W2172247201A5070823868 @default.
- W2172247201 hasAuthorship W2172247201A5086098906 @default.
- W2172247201 hasConcept C126322002 @default.
- W2172247201 hasConcept C126894567 @default.
- W2172247201 hasConcept C141071460 @default.
- W2172247201 hasConcept C2780252810 @default.
- W2172247201 hasConcept C2780303639 @default.
- W2172247201 hasConcept C2781307858 @default.
- W2172247201 hasConcept C2909675724 @default.
- W2172247201 hasConcept C2911091166 @default.
- W2172247201 hasConcept C31785415 @default.
- W2172247201 hasConcept C71924100 @default.
- W2172247201 hasConcept C90924648 @default.
- W2172247201 hasConceptScore W2172247201C126322002 @default.
- W2172247201 hasConceptScore W2172247201C126894567 @default.
- W2172247201 hasConceptScore W2172247201C141071460 @default.
- W2172247201 hasConceptScore W2172247201C2780252810 @default.
- W2172247201 hasConceptScore W2172247201C2780303639 @default.
- W2172247201 hasConceptScore W2172247201C2781307858 @default.
- W2172247201 hasConceptScore W2172247201C2909675724 @default.
- W2172247201 hasConceptScore W2172247201C2911091166 @default.
- W2172247201 hasConceptScore W2172247201C31785415 @default.
- W2172247201 hasConceptScore W2172247201C71924100 @default.
- W2172247201 hasConceptScore W2172247201C90924648 @default.
- W2172247201 hasIssue "4" @default.
- W2172247201 hasLocation W21722472011 @default.
- W2172247201 hasLocation W21722472012 @default.
- W2172247201 hasOpenAccess W2172247201 @default.
- W2172247201 hasPrimaryLocation W21722472011 @default.
- W2172247201 hasRelatedWork W1437713442 @default.
- W2172247201 hasRelatedWork W1999338607 @default.
- W2172247201 hasRelatedWork W2084149893 @default.
- W2172247201 hasRelatedWork W2891467435 @default.
- W2172247201 hasRelatedWork W2992668836 @default.
- W2172247201 hasRelatedWork W3031806456 @default.
- W2172247201 hasRelatedWork W4206820632 @default.
- W2172247201 hasRelatedWork W4287148464 @default.
- W2172247201 hasRelatedWork W4294161572 @default.
- W2172247201 hasRelatedWork W4296341699 @default.
- W2172247201 hasVolume "17" @default.
- W2172247201 isParatext "false" @default.
- W2172247201 isRetracted "false" @default.
- W2172247201 magId "2172247201" @default.
- W2172247201 workType "article" @default.