Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172260302> ?p ?o ?g. }
- W2172260302 endingPage "e34422" @default.
- W2172260302 startingPage "e34422" @default.
- W2172260302 abstract "Background Non-melanoma skin cancers are one of the most common human malignancies accounting for 2–3% of tumors in the US and represent a significant health burden. Epidemiology studies have implicated Tp53 mutations triggered by UV exposure, and human papilloma virus (HPV) infection to be significant causes of non-melanoma skin cancer. However, the relationship between Tp53 and cutaneous HPV infection is not well understood in skin cancers. In this study we assessed the association of HPV infection and Tp53 polymorphisms and mutations in lesional specimens with squamous cell carcinomas. Methods We studied 55 cases of histologically confirmed cutaneous squamous cell carcinoma and 41 controls for the presence of HPV infection and Tp53 genotype (mutations and polymorphism). Results We found an increased number of Tp53 mutations in the squamous cell carcinoma samples compared with perilesional or control samples. There was increased frequency of homozygous Tp53-72R polymorphism in cases with squamous cell carcinomas, while the Tp53-72P allele (Tp53-72R/P and Tp53-72P/P) was more frequent in normal control samples. Carcinoma samples positive for HPV showed a decreased frequency of Tp53 mutations compared to those without HPV infection. In addition, carcinoma samples with a Tp53-72P allele showed an increased incidence of Tp53 mutations in comparison carcinomas samples homozygous for Tp53-72R. Conclusions These studies suggest there are two separate pathways (HPV infection and Tp53 mutation) leading to cutaneous squamous cell carcinomas stratified by the Tp53 codon-72 polymorphism. The presence of a Tp53-72P allele is protective against cutaneous squamous cell carcinoma, and carcinoma specimens with Tp53-72P are more likely to have Tp53 mutations. In contrast Tp53-72R is a significant risk factor for cutaneous squamous cell carcinoma and is frequently associated with HPV infection instead of Tp53 mutations. Heterozygosity for Tp53-72R/P is protective against squamous cell carcinomas, possibly reflecting a requirement for both HPV infection and Tp53 mutations." @default.
- W2172260302 created "2016-06-24" @default.
- W2172260302 creator A5005382488 @default.
- W2172260302 creator A5015414714 @default.
- W2172260302 creator A5031542496 @default.
- W2172260302 creator A5050479239 @default.
- W2172260302 creator A5065358447 @default.
- W2172260302 creator A5073192771 @default.
- W2172260302 creator A5081343066 @default.
- W2172260302 creator A5083139067 @default.
- W2172260302 creator A5084630436 @default.
- W2172260302 date "2012-04-24" @default.
- W2172260302 modified "2023-10-18" @default.
- W2172260302 title "Analysis of Tp53 Codon 72 Polymorphisms, Tp53 Mutations, and HPV Infection in Cutaneous Squamous Cell Carcinomas" @default.
- W2172260302 cites W1566787829 @default.
- W2172260302 cites W1620032110 @default.
- W2172260302 cites W1640635403 @default.
- W2172260302 cites W1643155728 @default.
- W2172260302 cites W1964060678 @default.
- W2172260302 cites W1964997212 @default.
- W2172260302 cites W1966402708 @default.
- W2172260302 cites W1967629365 @default.
- W2172260302 cites W1969379999 @default.
- W2172260302 cites W1971170894 @default.
- W2172260302 cites W1978406229 @default.
- W2172260302 cites W1980366769 @default.
- W2172260302 cites W1983657855 @default.
- W2172260302 cites W1992301805 @default.
- W2172260302 cites W1992760686 @default.
- W2172260302 cites W1992864942 @default.
- W2172260302 cites W1998559412 @default.
- W2172260302 cites W2003154116 @default.
- W2172260302 cites W2004204418 @default.
- W2172260302 cites W2004637409 @default.
- W2172260302 cites W2005701686 @default.
- W2172260302 cites W2006413040 @default.
- W2172260302 cites W2007724420 @default.
- W2172260302 cites W2012812362 @default.
- W2172260302 cites W2017488658 @default.
- W2172260302 cites W2019564434 @default.
- W2172260302 cites W2020163558 @default.
- W2172260302 cites W2021684041 @default.
- W2172260302 cites W2024902613 @default.
- W2172260302 cites W2026641047 @default.
- W2172260302 cites W2031667694 @default.
- W2172260302 cites W2034247997 @default.
- W2172260302 cites W2035073821 @default.
- W2172260302 cites W2039189450 @default.
- W2172260302 cites W2043912950 @default.
- W2172260302 cites W2051350349 @default.
- W2172260302 cites W2054066786 @default.
- W2172260302 cites W2057854840 @default.
- W2172260302 cites W2061200607 @default.
- W2172260302 cites W2062312459 @default.
- W2172260302 cites W2063031396 @default.
- W2172260302 cites W2065643866 @default.
- W2172260302 cites W2074392394 @default.
- W2172260302 cites W2075230059 @default.
- W2172260302 cites W2076750276 @default.
- W2172260302 cites W2078222310 @default.
- W2172260302 cites W2080382868 @default.
- W2172260302 cites W2085676932 @default.
- W2172260302 cites W2086238536 @default.
- W2172260302 cites W2089472831 @default.
- W2172260302 cites W2090572476 @default.
- W2172260302 cites W2092094752 @default.
- W2172260302 cites W2092343492 @default.
- W2172260302 cites W2094731479 @default.
- W2172260302 cites W2097334501 @default.
- W2172260302 cites W2099436149 @default.
- W2172260302 cites W2101943966 @default.
- W2172260302 cites W2102656989 @default.
- W2172260302 cites W2113434385 @default.
- W2172260302 cites W2122133738 @default.
- W2172260302 cites W2123105305 @default.
- W2172260302 cites W2125125191 @default.
- W2172260302 cites W2125432782 @default.
- W2172260302 cites W2125965253 @default.
- W2172260302 cites W2128176696 @default.
- W2172260302 cites W2128537223 @default.
- W2172260302 cites W2133533823 @default.
- W2172260302 cites W2134048149 @default.
- W2172260302 cites W2134973144 @default.
- W2172260302 cites W2135800372 @default.
- W2172260302 cites W2139910900 @default.
- W2172260302 cites W2141761764 @default.
- W2172260302 cites W2150801016 @default.
- W2172260302 cites W2151037269 @default.
- W2172260302 cites W2151748492 @default.
- W2172260302 cites W2155569567 @default.
- W2172260302 cites W2158076001 @default.
- W2172260302 cites W2158301344 @default.
- W2172260302 cites W2158779427 @default.
- W2172260302 cites W2165101458 @default.
- W2172260302 cites W2168873062 @default.
- W2172260302 cites W2169266734 @default.
- W2172260302 cites W2171526822 @default.
- W2172260302 cites W2322842522 @default.