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- W2172289171 abstract "In laboratory mouse strains, only mice with the IghCa phenotype are able to mount an immune response against the alpha(1----3) glycosidic linkage of the B1355 dextran. The response is highly restricted with respect to utilization of only V lambda 1 and few related members of the VH558 family, and characterized by the production of cross-reacting (IdX), and individual (IdI) 104 and 558 idiotopes. We report in this study data showing a large degree of polymorphism in the anti-alpha(1----3)Dex response among 35 wild-derived mouse strains belonging to 4 different species. In contrast to the anti-alpha(1----3)Dex response of common laboratory strains, neither this response nor expression of the IdX, and IdI 104 and 558 idiotopes are linked to the IghCa haplotype. We also demonstrate co-expression on the same molecule of IdI 104 and IdI 558 idiotopes in wild mouse-derived hybridomas. These data challenge the idea of the exclusive expression at the molecular level of IdI 104 or IdI 558." @default.
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- W2172289171 date "1987-01-01" @default.
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- W2172289171 title "Idiotypic characteristics of λ1-bearing anti-α(1→3)dextran response in wild mice: high frequency of responder strains and co-expression of IdI 558 and IdI 104 on the same molecule" @default.
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- W2172289171 doi "https://doi.org/10.1002/eji.1830171212" @default.
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