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- W2172298488 abstract "Urine concentrating ability is reduced during normal aging in people and rats. The abundance of many of the key transport proteins that contribute to urine concentrating ability is reduced in the kidney medulla of aged rats. The reductions in water, sodium, and urea transport protein abundances, and their reduced response to water restriction, contribute to the reduced ability of aged rats to concentrate their urine and conserve water. If similar mechanisms occur in human kidneys, it would provide a molecular explanation for the reduced urine concentrating ability in aging and may provide opportunities for novel therapeutic approaches to improve urine concentrating ability and/or nocturnal polyuria." @default.
- W2172298488 created "2016-06-24" @default.
- W2172298488 creator A5014014770 @default.
- W2172298488 date "2012-05-15" @default.
- W2172298488 modified "2023-10-18" @default.
- W2172298488 title "Urine Concentrating and Diluting Ability During Aging" @default.
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- W2172298488 doi "https://doi.org/10.1093/gerona/gls128" @default.
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