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• W2172299216 endingPage "5440" @default.
• W2172299216 startingPage "5434" @default.
• W2172299216 abstract "Abstract TCR internalization takes place both in resting T cells as part of constitutive TCR cycling, after PKC activation, and during TCR triggering. It is still a matter of debate whether these pathways represent distinct pathways. Thus, some studies have indicated that ligand-induced TCR internalization is regulated by mechanisms distinct from those involved in constitutive internalization, whereas other studies have suggested that the ligand-induced TCR internalization pathway is identical with the constitutive pathway. To resolve this question, we first identified requirements for constitutive TCR cycling. We found that in contrast to PKC-induced TCR internalization where both CD3γ-S126 and the CD3γ leucine-based internalization motif are required, constitutive TCR cycling required neither PKC nor CD3γ-S126 but only the CD3γ leucine-based motif. Having identified these requirements, we next studied ligand-induced internalization in cells with abolished constitutive TCR cycling. We found that ligand-induced TCR internalization was not dependent on constitutive TCR internalization. Likewise, constitutive internalization and recycling of the TCR were independent of an intact ligand-induced internalization of the TCR. In conclusion, ligand-induced TCR internalization and constitutive cycling of the TCR represents two independent pathways regulated by different mechanisms." @default.
• W2172299216 created "2016-06-24" @default.
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• W2172299216 date "2002-06-01" @default.
• W2172299216 modified "2023-09-26" @default.
• W2172299216 title "Ligand-Induced TCR Down-Regulation Is Not Dependent on Constitutive TCR Cycling" @default.
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• W2172299216 doi "https://doi.org/10.4049/jimmunol.168.11.5434" @default.
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