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- W2172319351 endingPage "68" @default.
- W2172319351 startingPage "58" @default.
- W2172319351 abstract "For over 100 years, vaccines have been one of the most effective medical interventions for reducing infectious disease, and are estimated to save millions of lives globally each year. Nevertheless, many diseases are not yet preventable by vaccination. This large unmet medical need demands further research and the development of novel vaccines with high efficacy and safety. Compared to the 19th and early 20th century vaccines that were made of killed, inactivated, or live-attenuated pathogens, modern vaccines containing isolated, highly purified antigenic protein subunits are safer but tend to induce lower levels of protective immunity. One strategy to overcome the latter is to design antigen nanoparticles: assemblies of polypeptides that present multiple copies of subunit antigens in well-ordered arrays with defined orientations that can potentially mimic the repetitiveness, geometry, size, and shape of the natural host-pathogen surface interactions. Such nanoparticles offer a collective strength of multiple binding sites (avidity) and can provide improved antigen stability and immunogenicity. Several exciting advances have emerged lately, including preclinical evidence that this strategy may be applicable for the development of innovative new vaccines, for example, protecting against influenza, human immunodeficiency virus, and respiratory syncytial virus. Here, we provide a concise review of a critical selection of data that demonstrate the potential of this field. In addition, we highlight how the use of self-assembling protein nanoparticles can be effectively combined with the emerging discipline of structural vaccinology for maximum impact in the rational design of vaccine antigens." @default.
- W2172319351 created "2016-06-24" @default.
- W2172319351 creator A5008027591 @default.
- W2172319351 creator A5021475529 @default.
- W2172319351 creator A5058047069 @default.
- W2172319351 creator A5086124703 @default.
- W2172319351 date "2016-01-01" @default.
- W2172319351 modified "2023-10-10" @default.
- W2172319351 title "Self-assembling protein nanoparticles in the design of vaccines" @default.
- W2172319351 cites W122966762 @default.
- W2172319351 cites W1504983613 @default.
- W2172319351 cites W1522276317 @default.
- W2172319351 cites W1526618600 @default.
- W2172319351 cites W1543240545 @default.
- W2172319351 cites W1545488646 @default.
- W2172319351 cites W1604264892 @default.
- W2172319351 cites W1638707894 @default.
- W2172319351 cites W1767108689 @default.
- W2172319351 cites W1816587284 @default.
- W2172319351 cites W1829848714 @default.
- W2172319351 cites W1880317593 @default.
- W2172319351 cites W1902557223 @default.
- W2172319351 cites W1924246380 @default.
- W2172319351 cites W1931303047 @default.
- W2172319351 cites W1939629298 @default.
- W2172319351 cites W1948054437 @default.
- W2172319351 cites W1966012201 @default.
- W2172319351 cites W1967865769 @default.
- W2172319351 cites W1969760654 @default.
- W2172319351 cites W1970763651 @default.
- W2172319351 cites W1972529616 @default.
- W2172319351 cites W1972744160 @default.
- W2172319351 cites W1973749450 @default.
- W2172319351 cites W1974146156 @default.
- W2172319351 cites W1977952292 @default.
- W2172319351 cites W1978401933 @default.
- W2172319351 cites W1978480169 @default.
- W2172319351 cites W1979450297 @default.
- W2172319351 cites W1985255412 @default.
- W2172319351 cites W1987515055 @default.
- W2172319351 cites W1989355579 @default.
- W2172319351 cites W1991701295 @default.
- W2172319351 cites W1993063604 @default.
- W2172319351 cites W1996415437 @default.
- W2172319351 cites W1999088512 @default.
- W2172319351 cites W2000840731 @default.
- W2172319351 cites W2001197069 @default.
- W2172319351 cites W2002844537 @default.
- W2172319351 cites W2012660080 @default.
- W2172319351 cites W2015526636 @default.
- W2172319351 cites W2018007269 @default.
- W2172319351 cites W2018214960 @default.
- W2172319351 cites W2020740829 @default.
- W2172319351 cites W2024431338 @default.
- W2172319351 cites W2025212003 @default.
- W2172319351 cites W2025733005 @default.
- W2172319351 cites W2027261636 @default.
- W2172319351 cites W2028869643 @default.
- W2172319351 cites W2030692234 @default.
- W2172319351 cites W2031436792 @default.
- W2172319351 cites W2031539095 @default.
- W2172319351 cites W2033283933 @default.
- W2172319351 cites W2033867130 @default.
- W2172319351 cites W2035443610 @default.
- W2172319351 cites W2035867359 @default.
- W2172319351 cites W2037494332 @default.
- W2172319351 cites W2040299410 @default.
- W2172319351 cites W2042126545 @default.
- W2172319351 cites W2045946307 @default.
- W2172319351 cites W2046182783 @default.
- W2172319351 cites W2046768926 @default.
- W2172319351 cites W2048064261 @default.
- W2172319351 cites W2048932326 @default.
- W2172319351 cites W2049079862 @default.
- W2172319351 cites W2051546721 @default.
- W2172319351 cites W2051913120 @default.
- W2172319351 cites W2052937459 @default.
- W2172319351 cites W2053449687 @default.
- W2172319351 cites W2058615475 @default.
- W2172319351 cites W2061734833 @default.
- W2172319351 cites W2064572737 @default.
- W2172319351 cites W2065306943 @default.
- W2172319351 cites W2066355111 @default.
- W2172319351 cites W2073338313 @default.
- W2172319351 cites W2075172158 @default.
- W2172319351 cites W2075515367 @default.
- W2172319351 cites W2075527878 @default.
- W2172319351 cites W2077816413 @default.
- W2172319351 cites W2079290149 @default.
- W2172319351 cites W2081256243 @default.
- W2172319351 cites W2081393450 @default.
- W2172319351 cites W2085956518 @default.
- W2172319351 cites W2089726928 @default.
- W2172319351 cites W2094869942 @default.
- W2172319351 cites W2097061569 @default.
- W2172319351 cites W2097507146 @default.
- W2172319351 cites W2106183630 @default.
- W2172319351 cites W2107520340 @default.