FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172321884> ?p ?o ?g. }

• W2172321884 abstract "mRNAs containing premature termination codons (PTCs) are known to be degraded via nonsense-mediated mRNA decay (NMD). Unexpectedly, we found that mRNAs containing any type of PTCs (UAA, UAG, and UGA) are detained in the nucleus, whereas their wild-type counterparts are rapidly exported. This retention is strictly reading-frame dependent. Strikingly, our data indicate that translating ribosomes in the nucleus proofread the frame and detect the PTCs in the nucleus. Moreover, the shuttling NMD protein Upf1 specifically associates with PTC+mRNAs (PTC-containing mRNAs) in the nucleus and is required for nuclear retention of PTC+mRNAs. Together, our data lead to a working model that PTCs are recognized in the nucleus by translating ribosomes, resulting in recruitment of Upf1, which in turn functions in nuclear retention of PTC+mRNA. Nuclear PTC recognition adds a new layer of proofreading for mRNA and may be vital for ensuring the extraordinary fidelity required for protein production." @default.
• W2172321884 created "2016-06-24" @default.
• W2172321884 creator A5011464500 @default.
• W2172321884 creator A5016122096 @default.
• W2172321884 creator A5026610957 @default.
• W2172321884 creator A5026906414 @default.
• W2172321884 creator A5027833732 @default.
• W2172321884 creator A5030812792 @default.
• W2172321884 creator A5030850027 @default.
• W2172321884 creator A5033936341 @default.
• W2172321884 creator A5038314229 @default.
• W2172321884 creator A5054106473 @default.
• W2172321884 creator A5056932023 @default.
• W2172321884 creator A5058171187 @default.
• W2172321884 creator A5089967218 @default.
• W2172321884 date "2015-05-05" @default.
• W2172321884 modified "2023-10-17" @default.
• W2172321884 title "Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner" @default.
• W2172321884 cites W11549471 @default.
• W2172321884 cites W1268830682 @default.
• W2172321884 cites W1491060698 @default.
• W2172321884 cites W1807212217 @default.
• W2172321884 cites W1907299583 @default.
• W2172321884 cites W1938755197 @default.
• W2172321884 cites W1964129310 @default.
• W2172321884 cites W1965748552 @default.
• W2172321884 cites W1966735041 @default.
• W2172321884 cites W1967986998 @default.
• W2172321884 cites W1970313490 @default.
• W2172321884 cites W1975353293 @default.
• W2172321884 cites W1978116777 @default.
• W2172321884 cites W1980644980 @default.
• W2172321884 cites W1981334883 @default.
• W2172321884 cites W1997493439 @default.
• W2172321884 cites W1997980793 @default.
• W2172321884 cites W2003987858 @default.
• W2172321884 cites W2006931677 @default.
• W2172321884 cites W2011239877 @default.
• W2172321884 cites W2012852314 @default.
• W2172321884 cites W2014349878 @default.
• W2172321884 cites W2015087800 @default.
• W2172321884 cites W2015775176 @default.
• W2172321884 cites W2027159300 @default.
• W2172321884 cites W2029784766 @default.
• W2172321884 cites W2035995486 @default.
• W2172321884 cites W2038092250 @default.
• W2172321884 cites W2039585128 @default.
• W2172321884 cites W2041322170 @default.
• W2172321884 cites W2055526411 @default.
• W2172321884 cites W2057200757 @default.
• W2172321884 cites W2057892106 @default.
• W2172321884 cites W2060077330 @default.
• W2172321884 cites W2064036807 @default.
• W2172321884 cites W2075094914 @default.
• W2172321884 cites W2078655896 @default.
• W2172321884 cites W2081300509 @default.
• W2172321884 cites W2084212780 @default.
• W2172321884 cites W2092559748 @default.
• W2172321884 cites W2094883326 @default.
• W2172321884 cites W2101617498 @default.
• W2172321884 cites W2101990520 @default.
• W2172321884 cites W2102018304 @default.
• W2172321884 cites W2103250022 @default.
• W2172321884 cites W2109276727 @default.
• W2172321884 cites W2110105507 @default.
• W2172321884 cites W2114036672 @default.
• W2172321884 cites W2129247597 @default.
• W2172321884 cites W2130587866 @default.
• W2172321884 cites W2133205331 @default.
• W2172321884 cites W2133755885 @default.
• W2172321884 cites W2134288649 @default.
• W2172321884 cites W2137302306 @default.
• W2172321884 cites W2139078471 @default.
• W2172321884 cites W2143350291 @default.
• W2172321884 cites W2145322004 @default.
• W2172321884 cites W2150361747 @default.
• W2172321884 cites W2152975806 @default.
• W2172321884 cites W2154128645 @default.
• W2172321884 cites W2158017403 @default.
• W2172321884 cites W2158143427 @default.
• W2172321884 cites W2159666069 @default.
• W2172321884 cites W2171940869 @default.
• W2172321884 cites W2462348071 @default.
• W2172321884 cites W26440169 @default.
• W2172321884 doi "https://doi.org/10.1038/celldisc.2015.1" @default.
• W2172321884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4610414" @default.
• W2172321884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26491543" @default.
• W2172321884 hasPublicationYear "2015" @default.
• W2172321884 type Work @default.
• W2172321884 sameAs 2172321884 @default.
• W2172321884 citedByCount "31" @default.
• W2172321884 countsByYear W21723218842017 @default.
• W2172321884 countsByYear W21723218842018 @default.
• W2172321884 countsByYear W21723218842019 @default.
• W2172321884 countsByYear W21723218842020 @default.
• W2172321884 countsByYear W21723218842021 @default.
• W2172321884 countsByYear W21723218842022 @default.
• W2172321884 countsByYear W21723218842023 @default.
• W2172321884 crossrefType "journal-article" @default.
• W2172321884 hasAuthorship W2172321884A5011464500 @default.

• next