FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172400873> ?p ?o ?g. }

• W2172400873 endingPage "84" @default.
• W2172400873 startingPage "70" @default.
• W2172400873 abstract "Recent advances enabled by the Hi-C technique have unraveled many principles of chromosomal folding that were subsequently linked to disease and gene regulation. In particular, Hi-C revealed that chromosomes of animals are organized into topologically associating domains (TADs), evolutionary conserved compact chromatin domains that influence gene expression. Mechanisms that underlie partitioning of the genome into TADs remain poorly understood. To explore principles of TAD folding in Drosophila melanogaster, we performed Hi-C and poly(A)(+) RNA-seq in four cell lines of various origins (S2, Kc167, DmBG3-c2, and OSC). Contrary to previous studies, we find that regions between TADs (i.e., the inter-TADs and TAD boundaries) in Drosophila are only weakly enriched with the insulator protein dCTCF, while another insulator protein Su(Hw) is preferentially present within TADs. However, Drosophila inter-TADs harbor active chromatin and constitutively transcribed (housekeeping) genes. Accordingly, we find that binding of insulator proteins dCTCF and Su(Hw) predicts TAD boundaries much worse than active chromatin marks do. Interestingly, inter-TADs correspond to decompacted inter-bands of polytene chromosomes, whereas TADs mostly correspond to densely packed bands. Collectively, our results suggest that TADs are condensed chromatin domains depleted in active chromatin marks, separated by regions of active chromatin. We propose the mechanism of TAD self-assembly based on the ability of nucleosomes from inactive chromatin to aggregate, and lack of this ability in acetylated nucleosomal arrays. Finally, we test this hypothesis by polymer simulations and find that TAD partitioning may be explained by different modes of inter-nucleosomal interactions for active and inactive chromatin." @default.
• W2172400873 created "2016-06-24" @default.
• W2172400873 creator A5011546058 @default.
• W2172400873 creator A5016957787 @default.
• W2172400873 creator A5020453750 @default.
• W2172400873 creator A5021382553 @default.
• W2172400873 creator A5033657711 @default.
• W2172400873 creator A5036176580 @default.
• W2172400873 creator A5038422956 @default.
• W2172400873 creator A5059196144 @default.
• W2172400873 creator A5066655980 @default.
• W2172400873 creator A5075705622 @default.
• W2172400873 creator A5076540728 @default.
• W2172400873 creator A5090127511 @default.
• W2172400873 creator A5091717149 @default.
• W2172400873 date "2015-10-30" @default.
• W2172400873 modified "2023-10-17" @default.
• W2172400873 title "Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains" @default.
• W2172400873 cites W1859117663 @default.
• W2172400873 cites W1955892023 @default.
• W2172400873 cites W1961772435 @default.
• W2172400873 cites W1964184081 @default.
• W2172400873 cites W1964316283 @default.
• W2172400873 cites W1964649483 @default.
• W2172400873 cites W1965200310 @default.
• W2172400873 cites W1969468131 @default.
• W2172400873 cites W1970047592 @default.
• W2172400873 cites W1973062929 @default.
• W2172400873 cites W1975662785 @default.
• W2172400873 cites W1980430297 @default.
• W2172400873 cites W1980980040 @default.
• W2172400873 cites W1982484759 @default.
• W2172400873 cites W1989437252 @default.
• W2172400873 cites W1994031836 @default.
• W2172400873 cites W2002399114 @default.
• W2172400873 cites W2009653511 @default.
• W2172400873 cites W2011072181 @default.
• W2172400873 cites W2012523421 @default.
• W2172400873 cites W2015517537 @default.
• W2172400873 cites W2028118471 @default.
• W2172400873 cites W2029284014 @default.
• W2172400873 cites W2029492292 @default.
• W2172400873 cites W2030891958 @default.
• W2172400873 cites W2032140335 @default.
• W2172400873 cites W2032655419 @default.
• W2172400873 cites W2035322774 @default.
• W2172400873 cites W2035705082 @default.
• W2172400873 cites W2035903214 @default.
• W2172400873 cites W2037419514 @default.
• W2172400873 cites W2037589637 @default.
• W2172400873 cites W2042447587 @default.
• W2172400873 cites W2050690313 @default.
• W2172400873 cites W2052842503 @default.
• W2172400873 cites W2054864177 @default.
• W2172400873 cites W2056482755 @default.
• W2172400873 cites W2064537118 @default.
• W2172400873 cites W2065093957 @default.
• W2172400873 cites W2065817684 @default.
• W2172400873 cites W2069328568 @default.
• W2172400873 cites W2070021921 @default.
• W2172400873 cites W2073504534 @default.
• W2172400873 cites W2074588926 @default.
• W2172400873 cites W2079635700 @default.
• W2172400873 cites W2080477348 @default.
• W2172400873 cites W2080479776 @default.
• W2172400873 cites W2086575741 @default.
• W2172400873 cites W2090037139 @default.
• W2172400873 cites W2093310284 @default.
• W2172400873 cites W2097401587 @default.
• W2172400873 cites W2097798909 @default.
• W2172400873 cites W2098497185 @default.
• W2172400873 cites W2099357999 @default.
• W2172400873 cites W2101754326 @default.
• W2172400873 cites W2102619694 @default.
• W2172400873 cites W2104939587 @default.
• W2172400873 cites W2106619388 @default.
• W2172400873 cites W2107032654 @default.
• W2172400873 cites W2109949710 @default.
• W2172400873 cites W2111032472 @default.
• W2172400873 cites W2115685806 @default.
• W2172400873 cites W2116038761 @default.
• W2172400873 cites W2117977423 @default.
• W2172400873 cites W2127988376 @default.
• W2172400873 cites W2130116522 @default.
• W2172400873 cites W2132089243 @default.
• W2172400873 cites W2136583745 @default.
• W2172400873 cites W2138438730 @default.
• W2172400873 cites W2140729960 @default.
• W2172400873 cites W2144328273 @default.
• W2172400873 cites W2144792857 @default.
• W2172400873 cites W2145619687 @default.
• W2172400873 cites W2146005104 @default.
• W2172400873 cites W2150904790 @default.
• W2172400873 cites W2152605077 @default.
• W2172400873 cites W2157576490 @default.
• W2172400873 cites W2158747282 @default.
• W2172400873 cites W2159479483 @default.
• W2172400873 cites W2159969129 @default.

• next