Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172459898> ?p ?o ?g. }
- W2172459898 startingPage "017491" @default.
- W2172459898 abstract "Despite more than a decade of effort, the genetic underpinnings of many complex traits and diseases remain largely elusive. It is increasingly recognized that a purely additive model, upon which most genome-wide association studies (GWAS) rely, is insufficient. Although thousands of significant trait-associated loci have been identified, they often explain little of the inferred genetic variance. Several factors have been invoked to explain the ‘missing heritability’, including epistasis. Accounting for all possible epistatic interactions is computationally complex and requires very large samples. Here, we propose a simple two-state epistasis model, in which individuals show either high or low variant penetrance with respect to a certain trait. The use of this model increases the power to detect additive trait-associated loci. We show that this model is consistent with current GWAS results and better fits heritability observations based on twin studies. We suggest that accounting for variant penetrance will significantly increase our power to identify underlying additive loci." @default.
- W2172459898 created "2016-06-24" @default.
- W2172459898 creator A5050779824 @default.
- W2172459898 creator A5054191319 @default.
- W2172459898 date "2015-04-08" @default.
- W2172459898 modified "2023-09-27" @default.
- W2172459898 title "A Two-State Epistasis Model Better Explains Complex Traits and Increases Power to Detect Additive Risk Variants" @default.
- W2172459898 cites W1554180547 @default.
- W2172459898 cites W1558165107 @default.
- W2172459898 cites W1577941315 @default.
- W2172459898 cites W1760179322 @default.
- W2172459898 cites W1855179771 @default.
- W2172459898 cites W1964444099 @default.
- W2172459898 cites W1967485093 @default.
- W2172459898 cites W1969452055 @default.
- W2172459898 cites W1970044947 @default.
- W2172459898 cites W1971141173 @default.
- W2172459898 cites W1974934611 @default.
- W2172459898 cites W1975239838 @default.
- W2172459898 cites W1978150238 @default.
- W2172459898 cites W1980991473 @default.
- W2172459898 cites W1985849948 @default.
- W2172459898 cites W1987155068 @default.
- W2172459898 cites W1988263190 @default.
- W2172459898 cites W1988670106 @default.
- W2172459898 cites W1989706954 @default.
- W2172459898 cites W1992909271 @default.
- W2172459898 cites W2000768217 @default.
- W2172459898 cites W2002794037 @default.
- W2172459898 cites W2004444667 @default.
- W2172459898 cites W2010458876 @default.
- W2172459898 cites W2011197968 @default.
- W2172459898 cites W2012425756 @default.
- W2172459898 cites W2012457691 @default.
- W2172459898 cites W2014584925 @default.
- W2172459898 cites W2017695531 @default.
- W2172459898 cites W2020319451 @default.
- W2172459898 cites W2020845706 @default.
- W2172459898 cites W2024073332 @default.
- W2172459898 cites W2024502818 @default.
- W2172459898 cites W2025202959 @default.
- W2172459898 cites W2026833326 @default.
- W2172459898 cites W2026904717 @default.
- W2172459898 cites W2028197440 @default.
- W2172459898 cites W2029741513 @default.
- W2172459898 cites W2029757946 @default.
- W2172459898 cites W2031197222 @default.
- W2172459898 cites W2032254195 @default.
- W2172459898 cites W2032316603 @default.
- W2172459898 cites W2033021653 @default.
- W2172459898 cites W2036851890 @default.
- W2172459898 cites W2037723683 @default.
- W2172459898 cites W2043906174 @default.
- W2172459898 cites W2044761259 @default.
- W2172459898 cites W2045264377 @default.
- W2172459898 cites W2046919791 @default.
- W2172459898 cites W2048011602 @default.
- W2172459898 cites W2048258507 @default.
- W2172459898 cites W2049731252 @default.
- W2172459898 cites W2051355222 @default.
- W2172459898 cites W2052815101 @default.
- W2172459898 cites W2053824472 @default.
- W2172459898 cites W2056705950 @default.
- W2172459898 cites W2061550405 @default.
- W2172459898 cites W2062572978 @default.
- W2172459898 cites W2063661977 @default.
- W2172459898 cites W2064214582 @default.
- W2172459898 cites W2064332273 @default.
- W2172459898 cites W2067328319 @default.
- W2172459898 cites W2072214908 @default.
- W2172459898 cites W2074431333 @default.
- W2172459898 cites W2080847296 @default.
- W2172459898 cites W2081521541 @default.
- W2172459898 cites W2084663943 @default.
- W2172459898 cites W2086799994 @default.
- W2172459898 cites W2087206561 @default.
- W2172459898 cites W2091539743 @default.
- W2172459898 cites W2093356677 @default.
- W2172459898 cites W2093369971 @default.
- W2172459898 cites W2095241182 @default.
- W2172459898 cites W2098126593 @default.
- W2172459898 cites W2099027631 @default.
- W2172459898 cites W2099074956 @default.
- W2172459898 cites W2103012833 @default.
- W2172459898 cites W2104989261 @default.
- W2172459898 cites W2105557836 @default.
- W2172459898 cites W2110808585 @default.
- W2172459898 cites W2112542744 @default.
- W2172459898 cites W2115783720 @default.
- W2172459898 cites W2122031852 @default.
- W2172459898 cites W2123017873 @default.
- W2172459898 cites W2123739801 @default.
- W2172459898 cites W2126015874 @default.
- W2172459898 cites W2127494910 @default.
- W2172459898 cites W2127634492 @default.
- W2172459898 cites W2128161895 @default.
- W2172459898 cites W2131161884 @default.
- W2172459898 cites W2132853326 @default.
- W2172459898 cites W2134890298 @default.