FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172539968> ?p ?o ?g. }

• W2172539968 endingPage "2164" @default.
• W2172539968 startingPage "2158" @default.
• W2172539968 abstract "Selenium (Se) is an essential component for animals and human beings. The chemoprotective role of Se, via the regulation of the cell cycle, stimulation of apoptosis and activation of some cytokines among others, is well known; however, the comprehensive effects of Se on the expression of IGF-IR and its regulation of apoptosis have not been investigated. Thus the aim of this study was to report on the effects that different concentrations of Se extert on body weight, blood serum IGF-IR levels and histopathology in mice; and on IGF-IR expression, proliferation and apoptosis in mouse osteoblasts. In vivo experiments showed a significant decrease in body weight, serum levels of IGF-IR and prominent toxicant effects on the liver, kidney, heart and spleen following the administration of defined concentrations of Se for 30 d. However, moderate levels (0.1 mg/kg) of Se gradually improved weight and serum IGF-IR. In vitro osteoblast experiments revealed that at concentrations of 5 × 10−6 and 10−5 mol/L Se, MTT activity decreased in comparison with control cells. Cell cycle, TEM and caspase-3 activity supported these observations including an increase in the sub-G1 phase and notable apoptosis in osteoblasts, along with a decrease in the expression of mRNA and protein levels of IGF-IR. Moreover, the MTT activity, mRNA and protein levels of IGF-IR in osteoblasts were decreased and caspase-3 activity was increased in siRNA groups as compared with non-siRNA groups. These data suggest that Se significantly affects IGF-IR expression, and that it contributes to the proliferation and regulation of apoptosis in osteoblasts." @default.
• W2172539968 created "2016-06-24" @default.
• W2172539968 creator A5007571330 @default.
• W2172539968 creator A5011288065 @default.
• W2172539968 creator A5018271860 @default.
• W2172539968 creator A5046289609 @default.
• W2172539968 creator A5058234592 @default.
• W2172539968 creator A5060413120 @default.
• W2172539968 creator A5064293717 @default.
• W2172539968 creator A5070977836 @default.
• W2172539968 creator A5075382234 @default.
• W2172539968 creator A5089184357 @default.
• W2172539968 date "2016-02-01" @default.
• W2172539968 modified "2023-09-26" @default.
• W2172539968 title "The role of selenium in insulin-like growth factor I receptor (IGF-IR) expression and regulation of apoptosis in mouse osteoblasts" @default.
• W2172539968 cites W1509922868 @default.
• W2172539968 cites W1594906200 @default.
• W2172539968 cites W1904486154 @default.
• W2172539968 cites W1969073672 @default.
• W2172539968 cites W1978478927 @default.
• W2172539968 cites W1979012323 @default.
• W2172539968 cites W1981496258 @default.
• W2172539968 cites W1982882767 @default.
• W2172539968 cites W1982989163 @default.
• W2172539968 cites W1993054214 @default.
• W2172539968 cites W1994929980 @default.
• W2172539968 cites W2004633213 @default.
• W2172539968 cites W2005584771 @default.
• W2172539968 cites W2006489736 @default.
• W2172539968 cites W2010172631 @default.
• W2172539968 cites W2014823344 @default.
• W2172539968 cites W2016390309 @default.
• W2172539968 cites W2020962173 @default.
• W2172539968 cites W2021828567 @default.
• W2172539968 cites W2022027920 @default.
• W2172539968 cites W2031078050 @default.
• W2172539968 cites W2036333221 @default.
• W2172539968 cites W2039547268 @default.
• W2172539968 cites W2043748003 @default.
• W2172539968 cites W2065341781 @default.
• W2172539968 cites W2069642113 @default.
• W2172539968 cites W2076471323 @default.
• W2172539968 cites W2081829560 @default.
• W2172539968 cites W2083265178 @default.
• W2172539968 cites W2089953523 @default.
• W2172539968 cites W2090345243 @default.
• W2172539968 cites W2099736697 @default.
• W2172539968 cites W2114918609 @default.
• W2172539968 cites W2117934084 @default.
• W2172539968 cites W2123852291 @default.
• W2172539968 cites W2142573672 @default.
• W2172539968 cites W2147739301 @default.
• W2172539968 cites W2150660285 @default.
• W2172539968 cites W2156727062 @default.
• W2172539968 cites W2207813755 @default.
• W2172539968 cites W2325889810 @default.
• W2172539968 cites W4210999932 @default.
• W2172539968 cites W4253330428 @default.
• W2172539968 cites W52752946 @default.
• W2172539968 doi "https://doi.org/10.1016/j.chemosphere.2015.11.003" @default.
• W2172539968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26595309" @default.
• W2172539968 hasPublicationYear "2016" @default.
• W2172539968 type Work @default.
• W2172539968 sameAs 2172539968 @default.
• W2172539968 citedByCount "10" @default.
• W2172539968 countsByYear W21725399682016 @default.
• W2172539968 countsByYear W21725399682017 @default.
• W2172539968 countsByYear W21725399682018 @default.
• W2172539968 countsByYear W21725399682019 @default.
• W2172539968 countsByYear W21725399682020 @default.
• W2172539968 countsByYear W21725399682021 @default.
• W2172539968 crossrefType "journal-article" @default.
• W2172539968 hasAuthorship W2172539968A5007571330 @default.
• W2172539968 hasAuthorship W2172539968A5011288065 @default.
• W2172539968 hasAuthorship W2172539968A5018271860 @default.
• W2172539968 hasAuthorship W2172539968A5046289609 @default.
• W2172539968 hasAuthorship W2172539968A5058234592 @default.
• W2172539968 hasAuthorship W2172539968A5060413120 @default.
• W2172539968 hasAuthorship W2172539968A5064293717 @default.
• W2172539968 hasAuthorship W2172539968A5070977836 @default.
• W2172539968 hasAuthorship W2172539968A5075382234 @default.
• W2172539968 hasAuthorship W2172539968A5089184357 @default.
• W2172539968 hasConcept C126322002 @default.
• W2172539968 hasConcept C134018914 @default.
• W2172539968 hasConcept C170493617 @default.
• W2172539968 hasConcept C185592680 @default.
• W2172539968 hasConcept C190283241 @default.
• W2172539968 hasConcept C2775960820 @default.
• W2172539968 hasConcept C2780689927 @default.
• W2172539968 hasConcept C2780783641 @default.
• W2172539968 hasConcept C29537977 @default.
• W2172539968 hasConcept C55493867 @default.
• W2172539968 hasConcept C71924100 @default.
• W2172539968 hasConcept C86803240 @default.
• W2172539968 hasConceptScore W2172539968C126322002 @default.
• W2172539968 hasConceptScore W2172539968C134018914 @default.
• W2172539968 hasConceptScore W2172539968C170493617 @default.
• W2172539968 hasConceptScore W2172539968C185592680 @default.

• next