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• W2172602015 abstract "Objective: Limited information is available on chronic use of sodium glucose cotransporter 2 inhibitors in type 1 diabetes (T1D). We conducted a retrospective review of T1D patients on Dexcom G4Platinum continuous glucose monitors (DCGMs) >1 year (mean, 4.6 years) who were prescribed canagliflozin (CANA) 100 mg daily and had a baseline DCGM 30-day download prior to and a second download after at least 1 month (mean, 3.7 months) taking CANA 100 mg daily. The glycemic, weight, and systolic blood pressure (SBP) effects are reported. Methods: We identified 27 patients meeting the selection criteria: 14 men; 25 white; 22 on pump; average T1D duration, 34 years (range, 12 to 48 years); average hemoglobin A1C (A1C), 7.6% (range, 6.1 to 9.8%); 22 with baseline A1C 7.0% or higher. All patients had an estimated glomerular filtration rate (eGFR) at baseline of 60 mL/min/1.73 m2 or higher and were normotensive or on stable therapy. On average, 29 days of CGM data was reviewed. Total daily insulin dose (TDD) was available in 21 patients. We identified 27 patients who were judged to be candidates for CANA but did not have any change in glycemic therapy other than insulin adjustment as controls. Results: CANA resulted in significant reductions in mean blood glucose, CGM standard deviation, time in hyperglycemia, A1C, weight, SBP, and TDD, with increased time in target, with minimal increase in hypoglycemia and no significant change in eGFR. Three females developed genital mycotic infections but continued therapy, 2 developed ketoacidosis from insulin interruption. Conclusion: CANA offers promise as adjunct therapy in T1D, though caution is advised. Abbreviations: A1C = hemoglobin A1C CANA = canagliflozin CGM = continuous glucose monitor CSII = continuous subcutaneous insulin infusion DCGM = Dexcom G4Platinum CGM DKA = diabetic ketoacidosis GMI = genital mycotic infection MG = mean glucose PCGM = personal continuous glucose monitoring SBP = systolic blood pressure SGLT-2i = sodium-glucose cotransporter 2 inhibitor SH = severe hypoglycemia T2D = type 2 diabetes T1D = type 1 diabetes" @default.
• W2172602015 created "2016-06-24" @default.
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• W2172602015 date "2016-03-01" @default.
• W2172602015 modified "2023-09-27" @default.
• W2172602015 title "Glycemic Effects Of Sglt-2 Inhibitor Canagliflozin In Type 1 Diabetes Patients Using The Dexcom G4 Platinum Cgm" @default.
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• W2172602015 doi "https://doi.org/10.4158/ep151016.or" @default.
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