FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172689042> ?p ?o ?g. }

• W2172689042 endingPage "440" @default.
• W2172689042 startingPage "433" @default.
• W2172689042 abstract "Exposure to 50-60 Hz extremely low-frequency electromagnetic fields (ELF-EMFs) has increased considerably over the last decades. Several epidemiological studies suggested that ELF-EMF exposure is associated with adverse health effects, including neurotoxicity. However, these studies are debated as results are often contradictory and the possible underlying mechanisms are unknown. Since the developing nervous system is particularly vulnerable to insults, we investigate effects of chronic, developmental ELF-EMF exposure in vitro. Primary rat cortical neurons received 7 days developmental exposure to 50 Hz block-pulsed ELF-EMF (0-1000 μT) to assess effects on cell viability (Alamar Blue/CFDA assay), calcium homeostasis (single cell fluorescence microscopy), neurite outgrowth (β(III)-Tubulin immunofluorescent staining), and spontaneous neuronal activity (multi-electrode arrays). Our data demonstrate that cell viability is not affected by developmental ELF-EMF (0-1000 μT) exposure. Depolarization- and glutamate-evoked increases in intracellular calcium concentration ([Ca(2+)]i) are slightly increased at 1 μT, whereas both basal and stimulation-evoked [Ca(2+)]i show a modest inhibition at 1000 μT. Subsequent morphological analysis indicated that neurite length is unaffected up to 100 μT, but increased at 1000 μT. However, neuronal activity appeared largely unaltered following chronic ELF-EMF exposure up to 1000 μT. The effects of ELF-EMF exposure were small and largely restricted to the highest field strength (1000 μT), ie, 10 000 times above background exposure and well above current residential exposure limits. Our combined data therefore indicate that chronic ELF-EMF exposure has only limited (developmental) neurotoxic potential in vitro." @default.
• W2172689042 created "2016-06-24" @default.
• W2172689042 creator A5003354711 @default.
• W2172689042 creator A5009911361 @default.
• W2172689042 creator A5012987690 @default.
• W2172689042 creator A5048421494 @default.
• W2172689042 date "2015-11-15" @default.
• W2172689042 modified "2023-09-30" @default.
• W2172689042 title "<i>In Vitro</i>Developmental Neurotoxicity Following Chronic Exposure to 50 Hz Extremely Low-Frequency Electromagnetic Fields in Primary Rat Cortical Cultures" @default.
• W2172689042 cites W1604333472 @default.
• W2172689042 cites W1781581231 @default.
• W2172689042 cites W1964029870 @default.
• W2172689042 cites W1964820704 @default.
• W2172689042 cites W1966651109 @default.
• W2172689042 cites W1969355672 @default.
• W2172689042 cites W1971891696 @default.
• W2172689042 cites W1973774108 @default.
• W2172689042 cites W1974301144 @default.
• W2172689042 cites W1979425216 @default.
• W2172689042 cites W1988726757 @default.
• W2172689042 cites W1992159060 @default.
• W2172689042 cites W1996148043 @default.
• W2172689042 cites W2007297803 @default.
• W2172689042 cites W2022072609 @default.
• W2172689042 cites W2022191664 @default.
• W2172689042 cites W2030354892 @default.
• W2172689042 cites W2032200760 @default.
• W2172689042 cites W2043037379 @default.
• W2172689042 cites W2045260260 @default.
• W2172689042 cites W2048302631 @default.
• W2172689042 cites W2050049784 @default.
• W2172689042 cites W2058019848 @default.
• W2172689042 cites W2061784157 @default.
• W2172689042 cites W2067417913 @default.
• W2172689042 cites W2069418036 @default.
• W2172689042 cites W2072041185 @default.
• W2172689042 cites W2080209696 @default.
• W2172689042 cites W2084148692 @default.
• W2172689042 cites W2085596800 @default.
• W2172689042 cites W2086516865 @default.
• W2172689042 cites W2088870786 @default.
• W2172689042 cites W2095352259 @default.
• W2172689042 cites W2101346672 @default.
• W2172689042 cites W2106820442 @default.
• W2172689042 cites W2109867408 @default.
• W2172689042 cites W2115958435 @default.
• W2172689042 cites W2119857404 @default.
• W2172689042 cites W2130651831 @default.
• W2172689042 cites W2141260882 @default.
• W2172689042 cites W2141487738 @default.
• W2172689042 cites W2142981013 @default.
• W2172689042 cites W2153180445 @default.
• W2172689042 cites W2155535748 @default.
• W2172689042 cites W2159030941 @default.
• W2172689042 cites W2159533341 @default.
• W2172689042 cites W2320947692 @default.
• W2172689042 cites W2323726454 @default.
• W2172689042 cites W4214615809 @default.
• W2172689042 cites W4245167505 @default.
• W2172689042 cites W4248436058 @default.
• W2172689042 cites W4252486266 @default.
• W2172689042 cites W4255760236 @default.
• W2172689042 cites W884397879 @default.
• W2172689042 cites W2078319019 @default.
• W2172689042 doi "https://doi.org/10.1093/toxsci/kfv242" @default.
• W2172689042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26572663" @default.
• W2172689042 hasPublicationYear "2015" @default.
• W2172689042 type Work @default.
• W2172689042 sameAs 2172689042 @default.
• W2172689042 citedByCount "12" @default.
• W2172689042 countsByYear W21726890422016 @default.
• W2172689042 countsByYear W21726890422017 @default.
• W2172689042 countsByYear W21726890422018 @default.
• W2172689042 countsByYear W21726890422021 @default.
• W2172689042 countsByYear W21726890422022 @default.
• W2172689042 countsByYear W21726890422023 @default.
• W2172689042 crossrefType "journal-article" @default.
• W2172689042 hasAuthorship W2172689042A5003354711 @default.
• W2172689042 hasAuthorship W2172689042A5009911361 @default.
• W2172689042 hasAuthorship W2172689042A5012987690 @default.
• W2172689042 hasAuthorship W2172689042A5048421494 @default.
• W2172689042 hasBestOaLocation W21726890421 @default.
• W2172689042 hasConcept C113246987 @default.
• W2172689042 hasConcept C12554922 @default.
• W2172689042 hasConcept C126322002 @default.
• W2172689042 hasConcept C134018914 @default.
• W2172689042 hasConcept C169760540 @default.
• W2172689042 hasConcept C170493617 @default.
• W2172689042 hasConcept C181080969 @default.
• W2172689042 hasConcept C185592680 @default.
• W2172689042 hasConcept C202751555 @default.
• W2172689042 hasConcept C24998067 @default.
• W2172689042 hasConcept C2779491297 @default.
• W2172689042 hasConcept C29730261 @default.
• W2172689042 hasConcept C4141045 @default.
• W2172689042 hasConcept C519063684 @default.
• W2172689042 hasConcept C53227056 @default.
• W2172689042 hasConcept C55493867 @default.

• next