FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2172704920> ?p ?o ?g. }

• W2172704920 endingPage "387" @default.
• W2172704920 startingPage "378" @default.
• W2172704920 abstract "A novel kind of monodisperse mesoporous manganese silicate coated silica nanoparticle (MMSSN) as a highly efficient T1-weighted MRI contrast agent (CA) and drug carrier for cancer diagnosis and chemotherapy has been constructed by a modified SiO2 sacrifice and in situ silicate growth approach under a relatively low hydrothermal temperature and alkali-free condition. The mesoporous manganese silicate shell provides a large specific surface area and abundant exposed Mn paramagnetic centers to water molecules, which endows the MMSSNs with extraordinarily high longitudinal relaxivity. Meanwhile, the MMSSNs presented an efficient pH/redox-responsive T1-MRI feature based on the significant enhancement of relaxation rate (r1) stimulated by mild acidic environment or reducing agent (GSH) both in vitro and in vivo. Furthermore, the mesoporous structure and negatively charged pore surface of the manganese silicate shell enable the MMSSNs to attain anti-cancer drug (DOX) storage and a pH-responsive release, which is suitable for on-demand drug release for the chemotherapy of tumors. Therefore, the mesoporous manganese silicate-based nanomaterial is a promising candidate as T1-MRI CAs and anticancer-drug delivery carriers for the theranostics of tumor in an intelligent and on-demand manner.MRI is one of the most frequently used imaging techniques in daily clinics for cancer diagnosis. Using contrast agents (CAs) in MRI can afford much clearer and enlarged images of detectable organs. Gadolinium (Gd(3+))-based T1-positive CAs are widely used but associated with the risk of nephrogenic systemic fibrosis. To achieve much safer CAs, various Mn(2+)-based T1-positive CAs have been reported, such as MnO or core-shell MnOx-based nanoparticles. However, the efficiency of these CAs is still lower. Herein, we report a novel kind of mesoporous manganese silicate coated silica nanoparticle as CA and anti-cancer drug carrier. Results obtained from this study, especially the pH/redox-responsive T1-MRI feature are helpful for us to further design efficient MnSiO3-based materials for clinical MRI applications." @default.
• W2172704920 created "2016-06-24" @default.
• W2172704920 creator A5009691297 @default.
• W2172704920 creator A5028137251 @default.
• W2172704920 creator A5052676364 @default.
• W2172704920 creator A5053611461 @default.
• W2172704920 creator A5059032368 @default.
• W2172704920 creator A5067340985 @default.
• W2172704920 creator A5071382253 @default.
• W2172704920 creator A5085739377 @default.
• W2172704920 date "2016-01-01" @default.
• W2172704920 modified "2023-10-17" @default.
• W2172704920 title "Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T1-MRI contrast agents and drug delivery carriers" @default.
• W2172704920 cites W1888604776 @default.
• W2172704920 cites W1964796862 @default.
• W2172704920 cites W1965962082 @default.
• W2172704920 cites W1967222288 @default.
• W2172704920 cites W1967976272 @default.
• W2172704920 cites W1968322433 @default.
• W2172704920 cites W1969084610 @default.
• W2172704920 cites W1970735855 @default.
• W2172704920 cites W1978667826 @default.
• W2172704920 cites W1983147028 @default.
• W2172704920 cites W1985603134 @default.
• W2172704920 cites W1986593886 @default.
• W2172704920 cites W1988887982 @default.
• W2172704920 cites W1989941143 @default.
• W2172704920 cites W2010516979 @default.
• W2172704920 cites W2010852805 @default.
• W2172704920 cites W2017015459 @default.
• W2172704920 cites W2018095250 @default.
• W2172704920 cites W2021479394 @default.
• W2172704920 cites W2043836738 @default.
• W2172704920 cites W2045226800 @default.
• W2172704920 cites W2058503846 @default.
• W2172704920 cites W2065402868 @default.
• W2172704920 cites W2067267086 @default.
• W2172704920 cites W2069338957 @default.
• W2172704920 cites W2078107514 @default.
• W2172704920 cites W2078487098 @default.
• W2172704920 cites W2085605828 @default.
• W2172704920 cites W2092143317 @default.
• W2172704920 cites W2093360003 @default.
• W2172704920 cites W2096293149 @default.
• W2172704920 cites W2106821617 @default.
• W2172704920 cites W2120810754 @default.
• W2172704920 cites W2123571664 @default.
• W2172704920 cites W2127279078 @default.
• W2172704920 cites W2134659188 @default.
• W2172704920 cites W2135517762 @default.
• W2172704920 cites W2143896522 @default.
• W2172704920 cites W2145372034 @default.
• W2172704920 cites W2151755258 @default.
• W2172704920 cites W2164434551 @default.
• W2172704920 cites W2167632505 @default.
• W2172704920 cites W2167910719 @default.
• W2172704920 cites W2171128761 @default.
• W2172704920 cites W2280195996 @default.
• W2172704920 cites W2328216958 @default.
• W2172704920 cites W4236024787 @default.
• W2172704920 doi "https://doi.org/10.1016/j.actbio.2015.11.036" @default.
• W2172704920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26602820" @default.
• W2172704920 hasPublicationYear "2016" @default.
• W2172704920 type Work @default.
• W2172704920 sameAs 2172704920 @default.
• W2172704920 citedByCount "75" @default.
• W2172704920 countsByYear W21727049202016 @default.
• W2172704920 countsByYear W21727049202017 @default.
• W2172704920 countsByYear W21727049202018 @default.
• W2172704920 countsByYear W21727049202019 @default.
• W2172704920 countsByYear W21727049202020 @default.
• W2172704920 countsByYear W21727049202021 @default.
• W2172704920 countsByYear W21727049202022 @default.
• W2172704920 countsByYear W21727049202023 @default.
• W2172704920 crossrefType "journal-article" @default.
• W2172704920 hasAuthorship W2172704920A5009691297 @default.
• W2172704920 hasAuthorship W2172704920A5028137251 @default.
• W2172704920 hasAuthorship W2172704920A5052676364 @default.
• W2172704920 hasAuthorship W2172704920A5053611461 @default.
• W2172704920 hasAuthorship W2172704920A5059032368 @default.
• W2172704920 hasAuthorship W2172704920A5067340985 @default.
• W2172704920 hasAuthorship W2172704920A5071382253 @default.
• W2172704920 hasAuthorship W2172704920A5085739377 @default.
• W2172704920 hasConcept C13245373 @default.
• W2172704920 hasConcept C155672457 @default.
• W2172704920 hasConcept C161790260 @default.
• W2172704920 hasConcept C171250308 @default.
• W2172704920 hasConcept C178790620 @default.
• W2172704920 hasConcept C185592680 @default.
• W2172704920 hasConcept C191897082 @default.
• W2172704920 hasConcept C192562407 @default.
• W2172704920 hasConcept C2777335606 @default.
• W2172704920 hasConcept C2777496208 @default.
• W2172704920 hasConcept C2779820397 @default.
• W2172704920 hasConcept C557651011 @default.
• W2172704920 hasConcept C5913796 @default.
• W2172704920 hasConcept C82776694 @default.
• W2172704920 hasConceptScore W2172704920C13245373 @default.

• next