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- W2172802012 abstract "Acyl-CoA:cholesterol acyltransferase (E.C.2.3.1.26, ACAT) is a microsomial enzyme that catalyses the formation of cholesteryl esters by acylation of cholesterol with long chain fatty acylCoA [1].ACAT plays important roles in cellular homeostasis and in the early stages of atherosclerosis.Therefore, ACAT inhibitors have been identified as useful agents in the treatment of hypercholesterolemia, atherosclerosis and coronary diseases [2]. In addition, recently their application has been proposed for Alzheimer's disease [3]." @default.
- W2172802012 created "2016-06-24" @default.
- W2172802012 creator A5016623616 @default.
- W2172802012 date "2005-08-23" @default.
- W2172802012 modified "2023-09-25" @default.
- W2172802012 title "Pyridazine Derivatives as Novel Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitors" @default.
- W2172802012 cites W2950430203 @default.
- W2172802012 doi "https://doi.org/10.1002/chin.200534332" @default.
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