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• W2172810354 abstract "Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed." @default.
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• W2172810354 date "2004-04-01" @default.
• W2172810354 modified "2023-10-10" @default.
• W2172810354 title "Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum" @default.
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• W2172810354 doi "https://doi.org/10.1016/j.bmcl.2004.01.050" @default.
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